返回首页 在线留言 联系我们
首页 > 产品展示 > > 所有 > LKT Labs T1844 Telbivudine Nucleoside

产品中心

LKT Labs T1844 Telbivudine Nucleoside

  • 型   号:
  • 价   格:

LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。
美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。LKT Labs T1844 Telbivudine Nucleoside

分享到:

LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。
美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。

LKT Labs T1844 Telbivudine Nucleoside

LKT Labs T1844 Telbivudine Nucleoside

 

LKT A8812 AWD 131-138 25 mg 432.6 GABA-A positive modulator. 188116-07-6 ≥98% 279.72 C13H14ClN3O2 c1cc(ccc1N2CC(=NC2=O)N3CCOCC3)Cl Ambient "Rundfeldt C, Löscher W. The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs. 2014 Jan;28(1):29-43. PMID: 24357084.

 

Löscher W, Hoffmann K, Twele F, et al. The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs. Pharmacol Res. 2013 Nov;77:39-46. PMID: 24056205.

 

Yasar S, Bergman J, Munzar P, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65. PMID: 12681437.

" Not dangerous goods.

LKT A8812 AWD 131-138 50 mg 775.2 GABA-A positive modulator. 188116-07-6 ≥98% 279.72 C13H14ClN3O2 c1cc(ccc1N2CC(=NC2=O)N3CCOCC3)Cl Ambient "Rundfeldt C, Löscher W. The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs. 2014 Jan;28(1):29-43. PMID: 24357084.

 

Löscher W, Hoffmann K, Twele F, et al. The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs. Pharmacol Res. 2013 Nov;77:39-46. PMID: 24056205.

 

Yasar S, Bergman J, Munzar P, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65. PMID: 12681437.

" Not dangerous goods.

LKT T1953 Tenovin-3 5 mg 140.5 Potential p53 activator or SIRT2 inhibitor. 1011301-27-1 ≥98% 327.45 C18H21N3OS Ambient "Dogra S, Bandi S, Viswanathan P, et al. Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. Cancer Lett. 2015 Jan 28;356(2 Pt B):953-61. PMID: 25444910.

 

Sonnemann J, Marx C, Becker S, et al. p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.Br J Cancer. 2014 Feb 4;110(3):656-67. PMID: 24281001.

" Not dangerous goods.

LKT T1953 Tenovin-3 10 mg 224.7 Potential p53 activator or SIRT2 inhibitor. 1011301-27-1 ≥98% 327.45 C18H21N3OS Ambient "Dogra S, Bandi S, Viswanathan P, et al. Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. Cancer Lett. 2015 Jan 28;356(2 Pt B):953-61. PMID: 25444910.

 

Sonnemann J, Marx C, Becker S, et al. p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.Br J Cancer. 2014 Feb 4;110(3):656-67. PMID: 24281001.

" Not dangerous goods.

LKT T1953 Tenovin-3 25 mg 460.6 Potential p53 activator or SIRT2 inhibitor. 1011301-27-1 ≥98% 327.45 C18H21N3OS Ambient "Dogra S, Bandi S, Viswanathan P, et al. Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. Cancer Lett. 2015 Jan 28;356(2 Pt B):953-61. PMID: 25444910.

 

Sonnemann J, Marx C, Becker S, et al. p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.Br J Cancer. 2014 Feb 4;110(3):656-67. PMID: 24281001.

" Not dangerous goods.

LKT A5061 Ampalex 5 mg 95.6 Benzylpiperidine; AMPA potentiator. CX-516 154235-83-3 ≥98% 241.29 C14H15N3O "c1cc2c(cc1C(=O)N3CCCCC3)nccn2

" Ambient "O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. PMID: 17504104.

 

Olsen CK, Kreilgaard M, Didriksen M. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacol Biochem Behav. 2006 Jun;84(2):259-65. PMID: 16782180.

 

O'Neill MJ, Bleakman D, Zimmerman DM, et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. PMID: 15180479.

 

Danysz W. CX-516 (Cortex Pharmaceuticals Inc). IDrugs. 1999 Aug;2(8):814-22. PMID: 16127658.

" Not dangerous goods.

LKT A5061 Ampalex 10 mg 140.5 Benzylpiperidine; AMPA potentiator. CX-516 154235-83-3 ≥98% 241.29 C14H15N3O "c1cc2c(cc1C(=O)N3CCCCC3)nccn2

" Ambient "O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. PMID: 17504104.

 

Olsen CK, Kreilgaard M, Didriksen M. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacol Biochem Behav. 2006 Jun;84(2):259-65. PMID: 16782180.

 

O'Neill MJ, Bleakman D, Zimmerman DM, et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. PMID: 15180479.

 

Danysz W. CX-516 (Cortex Pharmaceuticals Inc). IDrugs. 1999 Aug;2(8):814-22. PMID: 16127658.

" Not dangerous goods.

LKT A5061 Ampalex 25 mg 275.3 Benzylpiperidine; AMPA potentiator. CX-516 154235-83-3 ≥98% 241.29 C14H15N3O "c1cc2c(cc1C(=O)N3CCCCC3)nccn2

" Ambient "O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. PMID: 17504104.

 

Olsen CK, Kreilgaard M, Didriksen M. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacol Biochem Behav. 2006 Jun;84(2):259-65. PMID: 16782180.

 

O'Neill MJ, Bleakman D, Zimmerman DM, et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. PMID: 15180479.

 

Danysz W. CX-516 (Cortex Pharmaceuticals Inc). IDrugs. 1999 Aug;2(8):814-22. PMID: 16127658.

" Not dangerous goods.

LKT C2540 CGK 733 5 mg 89.9 ATM and ATR inhibitor. CGK733, ATM/ATR Kinase Inhibitor 905973-89-9 ≥98% 555.83 C23H18Cl3FN4O3S "c1ccc(cc1)C(c2ccccc2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc3ccc(c(c3)[N+](=O)[O-])F

" Ambient "Jekimovs C, Bolderson E, Suraweera A, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol. 2014 Apr 22;4:86. PMID: 24795863.

 

Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. PMID: 19903334.

" Not dangerous goods.

LKT C2540 CGK 733 10 mg 140.5 ATM and ATR inhibitor. CGK733, ATM/ATR Kinase Inhibitor 905973-89-9 ≥98% 555.83 C23H18Cl3FN4O3S "c1ccc(cc1)C(c2ccccc2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc3ccc(c(c3)[N+](=O)[O-])F

" Ambient "Jekimovs C, Bolderson E, Suraweera A, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol. 2014 Apr 22;4:86. PMID: 24795863.

 

Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. PMID: 19903334.

" Not dangerous goods.

LKT C2540 CGK 733 25 mg 292.1 ATM and ATR inhibitor. CGK733, ATM/ATR Kinase Inhibitor 905973-89-9 ≥98% 555.83 C23H18Cl3FN4O3S "c1ccc(cc1)C(c2ccccc2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc3ccc(c(c3)[N+](=O)[O-])F

" Ambient "Jekimovs C, Bolderson E, Suraweera A, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol. 2014 Apr 22;4:86. PMID: 24795863.

 

Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. PMID: 19903334.

" Not dangerous goods.

LKT A6800 AR-A014418 5 mg 89.9 GSK-3β inhibitor. GSK-3β Inhibitor VIII 487021-52-3 ≥98% 308.31 C12H12N4O4S "COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]

" Ambient "Yadav AK, Vashishta V, Joshi N, et al. AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors. J Oncol. 2014;2014:695325. PMID: 24550987.

 

Weng HR, Gao M, Maixner DW. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Exp Neurol. 2014 Feb;252:18-27. PMID: 24275526.

 

King MR, Anderson NJ, Guernsey LS, et al. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013 Apr;91(4):506-14. PMID: 23362012.

 

Tunçdemir M, Yıldırım A, Karaoğlan A, et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur). 2013 Jan-Feb;24(1):22-32. PMID: 23116585.

" Not dangerous goods.

LKT A6800 AR-A014418 10 mg 140.5 GSK-3β inhibitor. GSK-3β Inhibitor VIII 487021-52-3 ≥98% 308.31 C12H12N4O4S "COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]

" Ambient "Yadav AK, Vashishta V, Joshi N, et al. AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors. J Oncol. 2014;2014:695325. PMID: 24550987.

 

Weng HR, Gao M, Maixner DW. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Exp Neurol. 2014 Feb;252:18-27. PMID: 24275526.

 

King MR, Anderson NJ, Guernsey LS, et al. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013 Apr;91(4):506-14. PMID: 23362012.

 

Tunçdemir M, Yıldırım A, Karaoğlan A, et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur). 2013 Jan-Feb;24(1):22-32. PMID: 23116585.

" Not dangerous goods.

LKT A6800 AR-A014418 25 mg 280.9 GSK-3β inhibitor. GSK-3β Inhibitor VIII 487021-52-3 ≥98% 308.31 C12H12N4O4S "COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]

" Ambient "Yadav AK, Vashishta V, Joshi N, et al. AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors. J Oncol. 2014;2014:695325. PMID: 24550987.

 

Weng HR, Gao M, Maixner DW. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Exp Neurol. 2014 Feb;252:18-27. PMID: 24275526.

 

King MR, Anderson NJ, Guernsey LS, et al. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013 Apr;91(4):506-14. PMID: 23362012.

 

Tunçdemir M, Yıldırım A, Karaoğlan A, et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur). 2013 Jan-Feb;24(1):22-32. PMID: 23116585.

" Not dangerous goods.

LKT J5237 JNJ-26854165 5 mg 140.5 MDM2 inhibitor. Serdemetan 881202-45-5 ≥98% 328.42 C21H20N4 "c1ccc2c(c1)c(c[nH]2)CCNc3ccc(cc3)Nc4ccncc4

" Ambient "Jones RJ, Gu D, Bjorklund CC, et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther. 2013 Sep;346(3):381-92. Erratum in: J Pharmacol Exp Ther. 2013 Nov;347(2):540.  PMID: 23820125.

 

Chargari C, Leteur C, Angevin E, et al. Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts. Cancer Lett. 2011 Dec 22;312(2):209-18. PMID: 21937165.

 

Kojima K, Burks JK, Arts J, et al. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 2010 Sep;9(9):2545-57. PMID: 20736344.

" Not dangerous goods.

LKT J5237 JNJ-26854165 25 mg 421.4 MDM2 inhibitor. Serdemetan 881202-45-5 ≥98% 328.42 C21H20N4 "c1ccc2c(c1)c(c[nH]2)CCNc3ccc(cc3)Nc4ccncc4

" Ambient "Jones RJ, Gu D, Bjorklund CC, et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther. 2013 Sep;346(3):381-92. Erratum in: J Pharmacol Exp Ther. 2013 Nov;347(2):540.  PMID: 23820125.

 

Chargari C, Leteur C, Angevin E, et al. Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts. Cancer Lett. 2011 Dec 22;312(2):209-18. PMID: 21937165.

 

Kojima K, Burks JK, Arts J, et al. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 2010 Sep;9(9):2545-57. PMID: 20736344.

" Not dangerous goods.

LKT C4417 Clemizole 5 mg 67.4 TRPC5 activator, NS4B and histamine H1 inhibitor. 442-52-4 ≥98% 325.84 C19H20ClN3 c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4 Ambient "Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

 

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

 

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

" Not dangerous goods.

LKT C4417 Clemizole 10 mg 101.1 TRPC5 activator, NS4B and histamine H1 inhibitor. 442-52-4 ≥98% 325.84 C19H20ClN3 c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4 Ambient "Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

 

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

 

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

" Not dangerous goods.

LKT C4417 Clemizole 25 mg 207.9 TRPC5 activator, NS4B and histamine H1 inhibitor. 442-52-4 ≥98% 325.84 C19H20ClN3 c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4 Ambient "Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

 

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

 

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

" Not dangerous goods.

LKT P8370 Purmorphamine 5 mg 110.1 Smo agonist. 483367-10-8 ≥98% 520.64 C31H32N6O2 "c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7

" Ambient "Wöltje M, Böbel M, Heiland M, et al. Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro. In Vivo. 2015 Mar-Apr;29(2):247-54. PMID: 25792653.

 

Chechneva OV, Mayrhofer F, Daugherty DJ, et al. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23;5:e1481. PMID: 25341035.

 

Wang Y, Han C, Lu L, et al. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology. 2013 Sep;58(3):995-1010. PMID: 23504944.

" Not dangerous goods.

LKT P8370 Purmorphamine 25 mg 432.6 Smo agonist. 483367-10-8 ≥98% 520.64 C31H32N6O2 "c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7

" Ambient "Wöltje M, Böbel M, Heiland M, et al. Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro. In Vivo. 2015 Mar-Apr;29(2):247-54. PMID: 25792653.

 

Chechneva OV, Mayrhofer F, Daugherty DJ, et al. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23;5:e1481. PMID: 25341035.

 

Wang Y, Han C, Lu L, et al. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology. 2013 Sep;58(3):995-1010. PMID: 23504944.

" Not dangerous goods.

LKT S4244 SKLB 610 5 mg 140.5 VEGFR2, PDGFR, FGFR2 inhibitor. 1125780-41-7 ≥98% 415.37 C21H16F3N3O3 Ambient "Luo X, Li S, Xie Y, et al. Pharmacokinetic studies of a novel multikinase inhibitor for treating cancer by HPLC-UV. J Chromatogr Sci. 2013 Jan;51(1):17-20. PMID: 22710664.

 

Cao ZX, Zheng RL, Lin HJ, et al. SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. Cell Physiol Biochem. 2011;27(5):565-74. PMID: 21691074.

" Not dangerous goods.

LKT S4244 SKLB 610 25 mg 426.9 VEGFR2, PDGFR, FGFR2 inhibitor. 1125780-41-7 ≥98% 415.37 C21H16F3N3O3 Ambient "Luo X, Li S, Xie Y, et al. Pharmacokinetic studies of a novel multikinase inhibitor for treating cancer by HPLC-UV. J Chromatogr Sci. 2013 Jan;51(1):17-20. PMID: 22710664.

 

Cao ZX, Zheng RL, Lin HJ, et al. SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. Cell Physiol Biochem. 2011;27(5):565-74. PMID: 21691074.

" Not dangerous goods.

LKT D9752 Dynasore 5 mg 56.2 Dynamin inhibitor. 304448-55-3 ≥98% 322.32 C18H14N2O4 Ambient "Mues MB, Cheshenko N, Wilson DW, et al. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul 1;89(13):6673-84. PMID: 25878109.

 

Thirukonda GJ, Uehara S, Nakayama T, et al. The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. J Bone Miner Metab. 2015 Jun 11. [Epub ahead of print]. PMID: 26063501.

 

Preta G, Cronin JG, Sheldon IM. Dynasore - not just a dynamin inhibitor. Cell Commun Signal. 2015 Apr 10;13:24. PMID: 25889964.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Dynasore)"

LKT D9752 Dynasore 25 mg 207.9 Dynamin inhibitor. 304448-55-3 ≥98% 322.32 C18H14N2O4 Ambient "Mues MB, Cheshenko N, Wilson DW, et al. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul 1;89(13):6673-84. PMID: 25878109.

 

Thirukonda GJ, Uehara S, Nakayama T, et al. The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. J Bone Miner Metab. 2015 Jun 11. [Epub ahead of print]. PMID: 26063501.

 

Preta G, Cronin JG, Sheldon IM. Dynasore - not just a dynamin inhibitor. Cell Commun Signal. 2015 Apr 10;13:24. PMID: 25889964.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Dynasore)"

LKT I0010 5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 5 mg 73.1 Intermediate in the synthesis of purine analogs and kinase inhibitors. 1246535-95-4 ≥98% 340.39 C16H20N8O Ambient Not dangerous goods.

LKT I0010 5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 25 mg 219.1 Intermediate in the synthesis of purine analogs and kinase inhibitors. 1246535-95-4 ≥98% 340.39 C16H20N8O Ambient Not dangerous goods.

LKT H6225 HPGDS-inhibitor-1 1 mg 84.3 HPGDS inhibitor. Prostaglandin D Synthase (hematopoietic-type) Inhibitor I 1033836-12-2 381.37 C19H19F4N3O Ambient Carron CP, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177. Not dangerous goods.

LKT H6225 HPGDS-inhibitor-1 5 mg 235.9 HPGDS inhibitor. Prostaglandin D Synthase (hematopoietic-type) Inhibitor I 1033836-12-2 381.37 C19H19F4N3O Ambient Carron CP, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177. Not dangerous goods.

LKT H6225 HPGDS-inhibitor-1 10 mg 432.6 HPGDS inhibitor. Prostaglandin D Synthase (hematopoietic-type) Inhibitor I 1033836-12-2 381.37 C19H19F4N3O Ambient Carron CP, Trujillo JI, Olson KL, et al. Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS). ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177. Not dangerous goods.

LKT M1444 MDL 29951 1 mg 50.6 GPR17 agonist, NMDA and fructose 1,6-bisphosphatase inhibitor. MDL29951 130798-51-5 ≥98% 302.11 C12H9Cl2NO4 Ambient "Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

 

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

 

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

 

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

" Not dangerous goods.

LKT M1444 MDL 29951 5 mg 163 GPR17 agonist, NMDA and fructose 1,6-bisphosphatase inhibitor. MDL29951 130798-51-5 ≥98% 302.11 C12H9Cl2NO4 Ambient "Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

 

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

 

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

 

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

" Not dangerous goods.

LKT M1444 MDL 29951 10 mg 252.8 GPR17 agonist, NMDA and fructose 1,6-bisphosphatase inhibitor. MDL29951 130798-51-5 ≥98% 302.11 C12H9Cl2NO4 Ambient "Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

 

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

 

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

 

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.

" Not dangerous goods.

LKT S0501 SB-939 5 mg 168.5 HDAC inhibitor. SB939, Pracinostat 929016-96-6 ≥98% 358.49 C20H30N4O2 "CCCCc1nc2cc(ccc2n1CCN(CC)CC)C=CC(=O)NO

" Ambient "Zorzi AP, Bernstein M, Samson Y, et al. A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium. Pediatr Blood Cancer. 2013 Nov;60(11):1868-74. PMID: 23893953.

 

Sumanadasa SD, Goodman CD, Lucke AJ, et al. Antimalarial activity of the anticancer histone deacetylase inhibitor SB939. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56. PMID: 22508312.

 

Novotny-Diermayr V, Sangthongpitag K, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. PMID: 20197387.

" Not dangerous goods.

LKT S0501 SB-939 25 mg 505.6 HDAC inhibitor. SB939, Pracinostat 929016-96-6 ≥98% 358.49 C20H30N4O2 "CCCCc1nc2cc(ccc2n1CCN(CC)CC)C=CC(=O)NO

" Ambient "Zorzi AP, Bernstein M, Samson Y, et al. A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium. Pediatr Blood Cancer. 2013 Nov;60(11):1868-74. PMID: 23893953.

 

Sumanadasa SD, Goodman CD, Lucke AJ, et al. Antimalarial activity of the anticancer histone deacetylase inhibitor SB939. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56. PMID: 22508312.

 

Novotny-Diermayr V, Sangthongpitag K, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. PMID: 20197387.

" Not dangerous goods.

LKT G8800 GW-788388 5 mg 95.6 ALK5 (activin-like) antagonist. 452342-67-5 ≥98% 425.49 C25H23N5O2 "c1ccnc(c1)c2c(c[nH]n2)c3ccnc(c3)c4ccc(cc4)C(=O)NC5CCOCC5

" Ambient "de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

 

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

 

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

" Not dangerous goods.

LKT G8800 GW-788388 25 mg 297.8 ALK5 (activin-like) antagonist. 452342-67-5 ≥98% 425.49 C25H23N5O2 "c1ccnc(c1)c2c(c[nH]n2)c3ccnc(c3)c4ccc(cc4)C(=O)NC5CCOCC5

" Ambient "de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

 

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

 

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

" Not dangerous goods.

LKT N4972 NMS-873 5 mg 97.8 Valosin-containing protein inhibitor. NMS873 1418013-75-8 ≥98% 520.67 C27H28N4O3S2 Ambient "Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.

 

Magnaghi P, D'Alessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.

" Not dangerous goods.

LKT N4972 NMS-873 25 mg 410.1 Valosin-containing protein inhibitor. NMS873 1418013-75-8 ≥98% 520.67 C27H28N4O3S2 Ambient "Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.

 

Magnaghi P, D'Alessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.

" Not dangerous goods.

LKT J8800 JW55 5 mg 84.3 TNKS1/2 inhibitor. 664993-53-7 ≥98% 434.49 C25H26N2O5 Ambient "Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889.

 

Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.

" Not dangerous goods.

LKT J8800 JW55 25 mg 365.2 TNKS1/2 inhibitor. 664993-53-7 ≥98% 434.49 C25H26N2O5 Ambient "Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889.

 

Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.

" Not dangerous goods.

LKT E7857 Etofenamate 10 mg 95.6 NSAID; COX-1/2 and lipoxygenase inhibitor. 30544-47-9 ≥98% 369.34 C18H18F3NO4 "c1ccc(c(c1)C(=O)OCCOCCO)Nc2cccc(c2)C(F)(F)F

" Ambient "Stratz T. Intramuscular etofenamate in the treatment of acute lumbago. Effectiveness and tolerance in comparison with intramuscular diclofenac-Na. Fortschr Med. 1990 Apr 30;108(13):264-6. PMID: 2142116.

 

Pelster B, Dell HD. Anti-inflammatory and analgesic activity of etofenamate after intramuscular injection in laboratory animals. Arzneimittelforschung. 1990 Mar;40(3):297-300. PMID: 2346539.

 

Nakamura H, Motoyoshi S, Ishii K, et al. The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamate. Nihon Yakurigaku Zasshi. 1987 Jan;89(1):15-24. PMID: 2883093.

" "UN number: 2810     Class: 6.1     Packing Group: III

Proper shipping name: Toxic liquid, organic, n.o.s. (Etofenamate)"

LKT E7857 Etofenamate 50 mg 309 NSAID; COX-1/2 and lipoxygenase inhibitor. 30544-47-9 ≥98% 369.34 C18H18F3NO4 "c1ccc(c(c1)C(=O)OCCOCCO)Nc2cccc(c2)C(F)(F)F

" Ambient "Stratz T. Intramuscular etofenamate in the treatment of acute lumbago. Effectiveness and tolerance in comparison with intramuscular diclofenac-Na. Fortschr Med. 1990 Apr 30;108(13):264-6. PMID: 2142116.

 

Pelster B, Dell HD. Anti-inflammatory and analgesic activity of etofenamate after intramuscular injection in laboratory animals. Arzneimittelforschung. 1990 Mar;40(3):297-300. PMID: 2346539.

 

Nakamura H, Motoyoshi S, Ishii K, et al. The mode of anti-inflammatory action of a topical non-steroidal anti-inflammatory drug, etofenamate. Nihon Yakurigaku Zasshi. 1987 Jan;89(1):15-24. PMID: 2883093.

" "UN number: 2810     Class: 6.1     Packing Group: III

Proper shipping name: Toxic liquid, organic, n.o.s. (Etofenamate)"

LKT T2668 TGR5 Receptor Agonist 5 mg 140.5 TGR5 agonist. TGR5 1197300-24-5 361.22 C18H14Cl2N2O2 Ambient "Duan H, Ning M, Chen X, et al. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. PMID: 23148522.

 

Inoue T, Wang JH, Higashiyama M, et al. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G810-6. PMID: 22821947.

 

Evans KA, Budzik BW, Ross SA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5. PMID: 19902954.

" Not dangerous goods.

LKT T2668 TGR5 Receptor Agonist 25 mg 449.4 TGR5 agonist. TGR5 1197300-24-5 361.22 C18H14Cl2N2O2 Ambient "Duan H, Ning M, Chen X, et al. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. PMID: 23148522.

 

Inoue T, Wang JH, Higashiyama M, et al. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G810-6. PMID: 22821947.

 

Evans KA, Budzik BW, Ross SA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5. PMID: 19902954.

" Not dangerous goods.

LKT N7332 NSI-189 1 mg 50.6 Stem cell neurogenesis inducer. NSI189 1270138-40-3 366.51 C22H30N4O "CC(C)CCNc1c(cccn1)C(=O)N2CCN(CC2)Cc3ccccc3

" Ambient "

 

 

" Not dangerous goods.

LKT N7332 NSI-189 5 mg 163 Stem cell neurogenesis inducer. NSI189 1270138-40-3 366.51 C22H30N4O "CC(C)CCNc1c(cccn1)C(=O)N2CCN(CC2)Cc3ccccc3

" Ambient "

 

 

" Not dangerous goods.

LKT N7332 NSI-189 25 mg 522.5 Stem cell neurogenesis inducer. NSI189 1270138-40-3 366.51 C22H30N4O "CC(C)CCNc1c(cccn1)C(=O)N2CCN(CC2)Cc3ccccc3

" Ambient "

 

LKT I0933 Icilin 10 mg 84.3 TRPM8 activator, TRPV3 blocker. AG 3-5 36945-98-9 311.3 C16H13N3O4 "c1ccc(c(c1)N2CC=C(NC2=O)c3cccc(c3)[N+](=O)[O-])O

" Ambient "Burgos-Vega CC, Ahn DD, Bischoff C, et al. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache. Cephalalgia. 2015 May 5. [Epub ahead of print]. PMID: 25944818.

 

Hosoya T, Matsumoto K, Tashima K, et al. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. Neurogastroenterol Motil. 2014 Aug;26(8):1112-21.PMID: 24832648.

 

Cucu D, Chiritoiu G, Petrescu S, et al. Characterization of functional transient receptor potential melastatin 8 channels in human pancreatic ductal adenocarcinoma cells. Pancreas. 2014 Jul;43(5):795-800. PMID: 24658318.

 

Hagenacker T, Lampe M, Schäfers M. Icilin reduces voltage-gated calcium channel currents in naïve and injured DRG neurons in the rat spinal nerve ligation model. Brain Res. 2014 Apr 4;1557:171-9. PMID: 24560602.

 

Lee S, Chun JN, Kim SH, et al. Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10. PMID: 24239550.

 

Ramachandran R, Hyun E, Zhao L, et al. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. PMID: 23596210.

 

Sherkheli MA, Gisselmann G, Hatt H. Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3. ScientificWorldJournal. 2012;2012:982725. PMID: 22548000.

" Not dangerous goods.

LKT I0933 Icilin 50 mg 348.3 TRPM8 activator, TRPV3 blocker. AG 3-5 36945-98-9 311.3 C16H13N3O4 "c1ccc(c(c1)N2CC=C(NC2=O)c3cccc(c3)[N+](=O)[O-])O

" Ambient "Burgos-Vega CC, Ahn DD, Bischoff C, et al. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache. Cephalalgia. 2015 May 5. [Epub ahead of print]. PMID: 25944818.

 

Hosoya T, Matsumoto K, Tashima K, et al. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. Neurogastroenterol Motil. 2014 Aug;26(8):1112-21.PMID: 24832648.

 

Cucu D, Chiritoiu G, Petrescu S, et al. Characterization of functional transient receptor potential melastatin 8 channels in human pancreatic ductal adenocarcinoma cells. Pancreas. 2014 Jul;43(5):795-800. PMID: 24658318.

 

Hagenacker T, Lampe M, Schäfers M. Icilin reduces voltage-gated calcium channel currents in naïve and injured DRG neurons in the rat spinal nerve ligation model. Brain Res. 2014 Apr 4;1557:171-9. PMID: 24560602.

 

Lee S, Chun JN, Kim SH, et al. Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10. PMID: 24239550.

 

Ramachandran R, Hyun E, Zhao L, et al. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. PMID: 23596210.

 

Sherkheli MA, Gisselmann G, Hatt H. Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3. ScientificWorldJournal. 2012;2012:982725. PMID: 22548000.

" Not dangerous goods.

LKT A6058 Apoptosis Activator 2 5 mg 89.9 Apoptosis inducing agent. AA-2; Apoptosis activator II; AA-II 79183-19-0 306.14 C15H9Cl2NO2 Ambient "Kim JH, Lee J. Induced neural stem cells protect neuronal cells against apoptosis. Med Sci Monit. 2014 Dec 22;20:2759-66. PMID: 25554259.

 

Farivar TN, Najafipour R, Johari P. Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. N Am J Med Sci. 2012 Nov;4(11):582-5. PMID: 23181231.

 

Nguyen TV, Jayaraman A, Quaglino A, et al. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22. PMID: 20561156.

" Not dangerous goods.

LKT A6058 Apoptosis Activator 2 10 mg 163 Apoptosis inducing agent. AA-2; Apoptosis activator II; AA-II 79183-19-0 306.14 C15H9Cl2NO2 Ambient "Kim JH, Lee J. Induced neural stem cells protect neuronal cells against apoptosis. Med Sci Monit. 2014 Dec 22;20:2759-66. PMID: 25554259.

 

Farivar TN, Najafipour R, Johari P. Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. N Am J Med Sci. 2012 Nov;4(11):582-5. PMID: 23181231.

 

Nguyen TV, Jayaraman A, Quaglino A, et al. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22. PMID: 20561156.

" Not dangerous goods.

LKT A6058 Apoptosis Activator 2 50 mg 505.6 Apoptosis inducing agent. AA-2; Apoptosis activator II; AA-II 79183-19-0 306.14 C15H9Cl2NO2 Ambient "Kim JH, Lee J. Induced neural stem cells protect neuronal cells against apoptosis. Med Sci Monit. 2014 Dec 22;20:2759-66. PMID: 25554259.

 

Farivar TN, Najafipour R, Johari P. Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. N Am J Med Sci. 2012 Nov;4(11):582-5. PMID: 23181231.

 

Nguyen TV, Jayaraman A, Quaglino A, et al. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22. PMID: 20561156.

" Not dangerous goods.

LKT D0261 Dapivirine 5 mg 163 RT inhibitor. TMC120 244767-67-7 329.41 C20H19N5 "Cc1cc(c(c(c1)C)Nc2ccnc(n2)Nc3ccc(cc3)C#N)C

" Ambient "Devlin B, Nuttall J, Wilder S, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8. PMID: 24188702.

 

Gupta SK, Nutan. Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS. HIV AIDS (Auckl). 2013 Oct 22;5:295-307. PMID: 24174883.

 

Njai HF, Lewi PJ, Janssen CG, et al. Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. Antivir Ther. 2005;10(2):255-62. PMID: 15865220.

 

Van Herrewege Y, Michiels J, Van Roey J, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. PMID: 14693562.

" Not dangerous goods.

LKT D0261 Dapivirine 25 mg 505.6 RT inhibitor. TMC120 244767-67-7 329.41 C20H19N5 "Cc1cc(c(c(c1)C)Nc2ccnc(n2)Nc3ccc(cc3)C#N)C

" Ambient "Devlin B, Nuttall J, Wilder S, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8. PMID: 24188702.

 

Gupta SK, Nutan. Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS. HIV AIDS (Auckl). 2013 Oct 22;5:295-307. PMID: 24174883.

 

Njai HF, Lewi PJ, Janssen CG, et al. Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. Antivir Ther. 2005;10(2):255-62. PMID: 15865220.

 

Van Herrewege Y, Michiels J, Van Roey J, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. PMID: 14693562.

" Not dangerous goods.

LKT S3568 Siramesine 5 mg 112.4 σ2 agonist. Lu-28-179 147817-50-3 ≥98% 454.59 C30H31FN2O "c1ccc2c(c1)COC23CCN(CC3)CCCCc4cn(c5c4cccc5)c6ccc(cc6)F

" Ambient "Česen MH, Repnik U, Turk V, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818. PMID: 24091661.

 

Spirkoski J, Melo FR, Grujic M, et al. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80. PMID: 23058984.

 

Sánchez C, Papp M. The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression. Behav Pharmacol. 2000 Apr;11(2):117-24. PMID: 10877116.

 

Sánchez C, Arnt J, Costall B, et al. The selective sigma2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J Pharmacol Exp Ther. 1997 Dec;283(3):1323-32. Erratum in: J Pharmacol Exp Ther 1998 May;285(2):929. PMID: 9400007.

" Not dangerous goods.

LKT S3568 Siramesine 25 mg 421.4 σ2 agonist. Lu-28-179 147817-50-3 ≥98% 454.59 C30H31FN2O "c1ccc2c(c1)COC23CCN(CC3)CCCCc4cn(c5c4cccc5)c6ccc(cc6)F

" Ambient "Česen MH, Repnik U, Turk V, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818. PMID: 24091661.

 

Spirkoski J, Melo FR, Grujic M, et al. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80. PMID: 23058984.

 

Sánchez C, Papp M. The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression. Behav Pharmacol. 2000 Apr;11(2):117-24. PMID: 10877116.

 

Sánchez C, Arnt J, Costall B, et al. The selective sigma2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J Pharmacol Exp Ther. 1997 Dec;283(3):1323-32. Erratum in: J Pharmacol Exp Ther 1998 May;285(2):929. PMID: 9400007.

" Not dangerous goods.

LKT S3368 S1RA 1 mg 140.5 σ1 antagonist. E52862, 4-Morpholine 878141-96-9 337.42 C20H23N3O2 "Cc1cc(nn1c2ccc3ccccc3c2)OCCN4CCOCC4

" Ambient "Gris G, Merlos M, Vela JM, et al. S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. Behav Pharmacol. 2014 Jun;25(3):226-35. PMID: 24776490.

 

Vidal-Torres A, Fernández-Pastor B, Carceller A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 May;129(3):484-94. PMID: 24384038.

 

Bura AS, Guegan T, Zamanillo D, et al. Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain. Eur J Pain. 2013 Jul;17(6):832-43. PMID: 23172791.

" Not dangerous goods.

LKT S3368 S1RA 5 mg 337.1 σ1 antagonist. E52862, 4-Morpholine 878141-96-9 337.42 C20H23N3O2 "Cc1cc(nn1c2ccc3ccccc3c2)OCCN4CCOCC4

" Ambient "Gris G, Merlos M, Vela JM, et al. S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. Behav Pharmacol. 2014 Jun;25(3):226-35. PMID: 24776490.

 

Vidal-Torres A, Fernández-Pastor B, Carceller A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 May;129(3):484-94. PMID: 24384038.

 

Bura AS, Guegan T, Zamanillo D, et al. Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain. Eur J Pain. 2013 Jul;17(6):832-43. PMID: 23172791.

" Not dangerous goods.

LKT S3368 S1RA 10 mg 646.1 σ1 antagonist. E52862, 4-Morpholine 878141-96-9 337.42 C20H23N3O2 "Cc1cc(nn1c2ccc3ccccc3c2)OCCN4CCOCC4

" Ambient "Gris G, Merlos M, Vela JM, et al. S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. Behav Pharmacol. 2014 Jun;25(3):226-35. PMID: 24776490.

 

Vidal-Torres A, Fernández-Pastor B, Carceller A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 May;129(3):484-94. PMID: 24384038.

 

Bura AS, Guegan T, Zamanillo D, et al. Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain. Eur J Pain. 2013 Jul;17(6):832-43. PMID: 23172791.

" Not dangerous goods.

LKT D6108 1,4-DPCA 5 mg 33.7 Prolyl hydroxylase inhibitor. 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one 331830-20-7 ≥98% 240.22 C13H8N2O3 Ambient -20°C "Zhang Y, Strehin I, Bedelbaeva K, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. PMID: 26041709.

 

Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. PMID: 24383403.

 

Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. PMID: 23766241.

" Not dangerous goods.

LKT D6108 1,4-DPCA 25 mg 140.5 Prolyl hydroxylase inhibitor. 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one 331830-20-7 ≥98% 240.22 C13H8N2O3 Ambient -20°C "Zhang Y, Strehin I, Bedelbaeva K, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. PMID: 26041709.

 

Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. PMID: 24383403.

 

Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. PMID: 23766241.

" Not dangerous goods.

LKT C4000 CK-636 5 mg 61.8 Arp2/3 inhibitor. CK636, CK-0944636 442632-72-6 ≥98% 284.38 C16H16N2OS Ambient "Zhou K, Muroyama A, Underwood J, et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9. PMID: 24043783.

 

Kwon KW, Park H, Doh J. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960. PMID: 24069255.

 

Nolen BJ, Tomasevic N, Russell A, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. PMID: 19648907.

" Not dangerous goods.

LKT C4000 CK-636 25 mg 252.8 Arp2/3 inhibitor. CK636, CK-0944636 442632-72-6 ≥98% 284.38 C16H16N2OS Ambient "Zhou K, Muroyama A, Underwood J, et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9. PMID: 24043783.

 

Kwon KW, Park H, Doh J. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960. PMID: 24069255.

 

Nolen BJ, Tomasevic N, Russell A, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. PMID: 19648907.

" Not dangerous goods.

LKT I5203 Inauhzin 5 mg 95.6 p53 activator, IMPDH and SIRT1 inhibitor. 309271-94-1 469.58 C25H19N5OS2 Ambient "Zhang Q, Zhou X, Wu R, et al. The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. Elife. 2014 Oct 27;3. PMID: 25347121.

 

Zhang Y, Zhang Q, Zeng SX, et al. Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PMID: 23633924.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Inauzhin)"

LKT I5203 Inauhzin 25 mg 387.7 p53 activator, IMPDH and SIRT1 inhibitor. 309271-94-1 469.58 C25H19N5OS2 Ambient "Zhang Q, Zhou X, Wu R, et al. The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. Elife. 2014 Oct 27;3. PMID: 25347121.

 

Zhang Y, Zhang Q, Zeng SX, et al. Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PMID: 23633924.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Inauzhin)"

LKT M3232 Methylisoindigotin 10 mg 56.2 Indirubin derivative. 1-Methyl-3,3'-biindole-2,2'(1H,1'H)-dione Meisoindigo, 4-Methylisoindigotin 97207-47-1 276.3 C17H12N2O2 "CN1c2ccccc2C(=C3c4ccccc4NC3=O)C1=O

" Ambient "Huang M, Lin HS, Lee YS, et al. Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. Int J Oncol. 2014 Oct;45(4):1724-34. PMID: 25050545.

 

Zhang HJ, Zhang Y, Jin J, et al. Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways. Yao Xue Xue Bao. 2013 Apr;48(4):503-7. PMID: 23833936.

 

Zuo MX, Li Y, Zhou JH, et al. Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):579-82. PMID: 20561405.

 

Mingxin Z, Yan L, Hongbo W, et al. The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. J Chemother. 2008 Dec;20(6):728-33. PMID: 19129071.

 

Xiao Z, Wang Y, Lu L, et al. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk Res. 2006 Jan;30(1):54-9. PMID: 15982734.

" Not dangerous goods.

LKT M3232 Methylisoindigotin 50 mg 202.2 Indirubin derivative. 1-Methyl-3,3'-biindole-2,2'(1H,1'H)-dione Meisoindigo, 4-Methylisoindigotin 97207-47-1 276.3 C17H12N2O2 "CN1c2ccccc2C(=C3c4ccccc4NC3=O)C1=O

" Ambient "Huang M, Lin HS, Lee YS, et al. Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. Int J Oncol. 2014 Oct;45(4):1724-34. PMID: 25050545.

 

Zhang HJ, Zhang Y, Jin J, et al. Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways. Yao Xue Xue Bao. 2013 Apr;48(4):503-7. PMID: 23833936.

 

Zuo MX, Li Y, Zhou JH, et al. Effect of Meisoindigo on Wnt signal pathway in K562 and HL-60 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):579-82. PMID: 20561405.

 

Mingxin Z, Yan L, Hongbo W, et al. The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo. J Chemother. 2008 Dec;20(6):728-33. PMID: 19129071.

 

Xiao Z, Wang Y, Lu L, et al. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk Res. 2006 Jan;30(1):54-9. PMID: 15982734.

" Not dangerous goods.

LKT B0245 Balicatib 5 mg 95.6 Cathepsin K inhibitor. AAE-581 354813-19-7 411.55 C23H33N5O2 "CCCN1CCN(CC1)c2ccc(cc2)C(=O)NC3(CCCCC3)C(=O)NCC#N

" Ambient "Jerome C, Missbach M, Gamse R. Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int. 2012 Jan;23(1):339-49. PMID: 21380636.

 

Chappard D, Libouban H, Mindeholm L, et al. The cathepsin K inhibitor AAE581 induces morphological changes in osteoclasts of treated patients. Microsc Res Tech. 2010 Jul;73(7):726-32. PMID: 20025055.

" Not dangerous goods.

LKT B0245 Balicatib 25 mg 314.6 Cathepsin K inhibitor. AAE-581 354813-19-7 411.55 C23H33N5O2 "CCCN1CCN(CC1)c2ccc(cc2)C(=O)NC3(CCCCC3)C(=O)NCC#N

" Ambient "Jerome C, Missbach M, Gamse R. Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int. 2012 Jan;23(1):339-49. PMID: 21380636.

 

Chappard D, Libouban H, Mindeholm L, et al. The cathepsin K inhibitor AAE581 induces morphological changes in osteoclasts of treated patients. Microsc Res Tech. 2010 Jul;73(7):726-32. PMID: 20025055.

" Not dangerous goods.

LKT W0247 Walrycin B 1 mg 95.6 Walrycin response regulator inhibitor. 878419-78-4 337.26 C14H10F3N5O2 Ambient Gotoh Y, Doi A, Furuta E, et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo). 2010 Mar;63(3):127-34. PMID: 20111065. Not dangerous goods.

LKT W0247 Walrycin B 5 mg 309 Walrycin response regulator inhibitor. 878419-78-4 337.26 C14H10F3N5O2 Ambient Gotoh Y, Doi A, Furuta E, et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo). 2010 Mar;63(3):127-34. PMID: 20111065. Not dangerous goods.

LKT W0247 Walrycin B 25 mg 842.6 Walrycin response regulator inhibitor. 878419-78-4 337.26 C14H10F3N5O2 Ambient Gotoh Y, Doi A, Furuta E, et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator. J Antibiot (Tokyo). 2010 Mar;63(3):127-34. PMID: 20111065. Not dangerous goods.

LKT G5322 GNF-5 5 mg 39.4 Abl inhibitor. 778277-15-9 ≥98% 418.38 C20H17F3N4O3 "c1cc(cc(c1)C(=O)NCCO)c2cc(ncn2)Nc3ccc(cc3)OC(F)(F)F

" Ambient "Karunakaran U, Park SJ, Jun do Y, et al. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cell Signal. 2015 Jun;27(6):1066-74. PMID: 25683919.

 

Chen S, Tang DD. c-Abl tyrosine kinase regulates cytokinesis of human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1076-83. PMID: 24392933.

 

Cleary RA, Wang R, Wang T, et al. Role of Abl in airway hyperresponsiveness and airway remodeling. Respir Res. 2013 Oct 11;14:105. PMID: 24112389.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (GNF-5)"

LKT G5322 GNF-5 25 mg 110.1 Abl inhibitor. 778277-15-9 ≥98% 418.38 C20H17F3N4O3 "c1cc(cc(c1)C(=O)NCCO)c2cc(ncn2)Nc3ccc(cc3)OC(F)(F)F

" Ambient "Karunakaran U, Park SJ, Jun do Y, et al. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cell Signal. 2015 Jun;27(6):1066-74. PMID: 25683919.

 

Chen S, Tang DD. c-Abl tyrosine kinase regulates cytokinesis of human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1076-83. PMID: 24392933.

 

Cleary RA, Wang R, Wang T, et al. Role of Abl in airway hyperresponsiveness and airway remodeling. Respir Res. 2013 Oct 11;14:105. PMID: 24112389.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (GNF-5)"

LKT G5322 GNF-5 100 mg 348.3 Abl inhibitor. 778277-15-9 ≥98% 418.38 C20H17F3N4O3 "c1cc(cc(c1)C(=O)NCCO)c2cc(ncn2)Nc3ccc(cc3)OC(F)(F)F

" Ambient "Karunakaran U, Park SJ, Jun do Y, et al. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cell Signal. 2015 Jun;27(6):1066-74. PMID: 25683919.

 

Chen S, Tang DD. c-Abl tyrosine kinase regulates cytokinesis of human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1076-83. PMID: 24392933.

 

Cleary RA, Wang R, Wang T, et al. Role of Abl in airway hyperresponsiveness and airway remodeling. Respir Res. 2013 Oct 11;14:105. PMID: 24112389.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (GNF-5)"

LKT D1872 Des(benzylpyridyl) Atazanavir 5 mg 207.9 Atazanavir metabolite; HIV protease inhibitor. 1192224-24-0 537.66 C26H43N5O7 Ambient ter Heine R, Hillebrand MJ, Rosing H, et al. Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor. Drug Metab Dispos. 2009 Sep;37(9):1826-40. PMID: 19546238.

LKT D1872 Des(benzylpyridyl) Atazanavir 10 mg 393.2 Atazanavir metabolite; HIV protease inhibitor. 1192224-24-0 537.66 C26H43N5O7 Ambient ter Heine R, Hillebrand MJ, Rosing H, et al. Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor. Drug Metab Dispos. 2009 Sep;37(9):1826-40. PMID: 19546238.

LKT D1872 Des(benzylpyridyl) Atazanavir 25 mg 898.8 Atazanavir metabolite; HIV protease inhibitor. 1192224-24-0 537.66 C26H43N5O7 Ambient ter Heine R, Hillebrand MJ, Rosing H, et al. Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor. Drug Metab Dispos. 2009 Sep;37(9):1826-40. PMID: 19546238.

LKT S4932 SMI-4a 5 mg 56.2 Thiazolidine; Pim kinase inhibitor. 438190-29-5 273.23 C11H6F3NO2S Ambient "Yang J, Wang J, Chen K, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. PMID: 23749639.

 

Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. PMID: 19965690.

" Not dangerous goods.

LKT S4932 SMI-4a 10 mg 95.6 Thiazolidine; Pim kinase inhibitor. 438190-29-5 273.23 C11H6F3NO2S Ambient "Yang J, Wang J, Chen K, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. PMID: 23749639.

 

Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. PMID: 19965690.

" Not dangerous goods.

LKT S4932 SMI-4a 25 mg 196.7 Thiazolidine; Pim kinase inhibitor. 438190-29-5 273.23 C11H6F3NO2S Ambient "Yang J, Wang J, Chen K, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. PMID: 23749639.

 

Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. PMID: 19965690.

" Not dangerous goods.

LKT V2792 VGX-1027 5 mg 60.7 TLR4 inhibitor. GIT27 6501-72-0 205.21 C11H11NO3 Ambient "Fagone P, Muthumani K, Mangano K, et al. VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus. Immunology. 2014 Aug;142(4):594-602. PMID: 24527796.

 

Cha JJ, Hyun YY, Lee MH, et al. Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology. 2013 Jun;154(6):2144-55. PMID: 23568555.

 

Stojanovic I, Cuzzocrea S, Mangano K, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol. 2007 Jun;123(3):311-23. PMID: 17449326.

" Not dangerous goods.

LKT V2792 VGX-1027 10 mg 103.3 TLR4 inhibitor. GIT27 6501-72-0 205.21 C11H11NO3 Ambient "Fagone P, Muthumani K, Mangano K, et al. VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus. Immunology. 2014 Aug;142(4):594-602. PMID: 24527796.

 

Cha JJ, Hyun YY, Lee MH, et al. Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology. 2013 Jun;154(6):2144-55. PMID: 23568555.

 

Stojanovic I, Cuzzocrea S, Mangano K, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol. 2007 Jun;123(3):311-23. PMID: 17449326.

" Not dangerous goods.

LKT V2792 VGX-1027 50 mg 404.5 TLR4 inhibitor. GIT27 6501-72-0 205.21 C11H11NO3 Ambient "Fagone P, Muthumani K, Mangano K, et al. VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus. Immunology. 2014 Aug;142(4):594-602. PMID: 24527796.

 

Cha JJ, Hyun YY, Lee MH, et al. Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology. 2013 Jun;154(6):2144-55. PMID: 23568555.

 

Stojanovic I, Cuzzocrea S, Mangano K, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol. 2007 Jun;123(3):311-23. PMID: 17449326.

" Not dangerous goods.

LKT Y0002 Y-320 5 mg 140.5 Phenylpyrazoleanilide; IL-17 production inhibitor. Y320 288250-47-5 ≥98% 505.02 C27H29ClN6O2 Ambient "Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.

 

 

Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.

" Not dangerous goods.

LKT Y0002 Y-320 10 mg 252.8 Phenylpyrazoleanilide; IL-17 production inhibitor. Y320 288250-47-5 ≥98% 505.02 C27H29ClN6O2 Ambient "Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.

 

 

Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.

" Not dangerous goods.

LKT Y0002 Y-320 25 mg 505.6 Phenylpyrazoleanilide; IL-17 production inhibitor. Y320 288250-47-5 ≥98% 505.02 C27H29ClN6O2 Ambient "Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.

 

 

Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.

" Not dangerous goods.

LKT A7725 Atglistatin 5 mg 84.3 ATGL inhibitor. 1469924-27-3 283.38 C17H21N3O Ambient "Zhang H, Sun T, Jiang X, et al. PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL. J Transl Med. 2015 Feb 21;13:68. PMID: 25890298.

 

Cerk IK, Salzburger B, Boeszoermenyi A, et al. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem. 2014 Nov 21;289(47):32559-70. PMID: 25258314.

 

Mayer N, Schweiger M, Romauch M, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013 Dec;9(12):785-7. PMID: 24096302.

" Not dangerous goods.

LKT A7725 Atglistatin 25 mg 325.8 ATGL inhibitor. 1469924-27-3 283.38 C17H21N3O Ambient "Zhang H, Sun T, Jiang X, et al. PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL. J Transl Med. 2015 Feb 21;13:68. PMID: 25890298.

 

Cerk IK, Salzburger B, Boeszoermenyi A, et al. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem. 2014 Nov 21;289(47):32559-70. PMID: 25258314.

 

Mayer N, Schweiger M, Romauch M, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013 Dec;9(12):785-7. PMID: 24096302.

" Not dangerous goods.

LKT T3568 Tirasemtiv 1 mg 89.9 Fast skeletal muscle troponin complex activator. CK-2017357 1005491-05-3 230.27 C12H14N4O "CCC(CC)n1c2c(ncc(n2)C#C)nc1O

" Ambient "Sanders DB, Rosenfeld J, Dimachkie MM, et al. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. PMID: 25742919.

 

Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. PMID: 24805850.

 

Russell AJ, Hartman JJ, Hinken AC, et al. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. PMID: 22344294.

"

LKT T3568 Tirasemtiv 5 mg 314.6 Fast skeletal muscle troponin complex activator. CK-2017357 1005491-05-3 230.27 C12H14N4O "CCC(CC)n1c2c(ncc(n2)C#C)nc1O

" Ambient "Sanders DB, Rosenfeld J, Dimachkie MM, et al. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. PMID: 25742919.

 

Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. PMID: 24805850.

 

Russell AJ, Hartman JJ, Hinken AC, et al. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. PMID: 22344294.

"

LKT T3568 Tirasemtiv 25 mg 955 Fast skeletal muscle troponin complex activator. CK-2017357 1005491-05-3 230.27 C12H14N4O "CCC(CC)n1c2c(ncc(n2)C#C)nc1O

" Ambient "Sanders DB, Rosenfeld J, Dimachkie MM, et al. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. PMID: 25742919.

 

Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. PMID: 24805850.

 

Russell AJ, Hartman JJ, Hinken AC, et al. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. PMID: 22344294.

"

LKT K5604 Kobe 0065 5 mg 84.3 Ras inhibitor. 436133-68-5 449.79 C15H11ClF3N5O4S Ambient "Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.

 

Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.

" Not dangerous goods.

LKT K5604 Kobe 0065 25 mg 331.5 Ras inhibitor. 436133-68-5 449.79 C15H11ClF3N5O4S Ambient "Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.

 

Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.

" Not dangerous goods.

LKT C9200 CX-6258 5 mg 112.4 Pim kinase inhibitor. 1202916-90-2 461.95 C26H24ClN3O3 Ambient "Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7. PMID: 23129228.

 

Haddach M, Michaux J, Schwaebe MK, et al. Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett. 2011 Dec 27;3(2):135-9. PMID: 24900437.

" Not dangerous goods.

LKT C9200 CX-6258 25 mg 359.5 Pim kinase inhibitor. 1202916-90-2 461.95 C26H24ClN3O3 Ambient "Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7. PMID: 23129228.

 

Haddach M, Michaux J, Schwaebe MK, et al. Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett. 2011 Dec 27;3(2):135-9. PMID: 24900437.

" Not dangerous goods.

LKT P6264 PPQ-102 5 mg 89.9 Pyramido-pyrrolo-quinoxalinedione; CFTR blocker. 931706-15-9 ≥98% 438.49 C26H22N4O3 Ambient "Snyder DS, Tradtrantip L, Yao C, et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. PMID: 21707078.

 

Tradtrantip L, Sonawane ND, Namkung W, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. PMID: 19785436.

" Not dangerous goods.

LKT P6264 PPQ-102 10 mg 163 Pyramido-pyrrolo-quinoxalinedione; CFTR blocker. 931706-15-9 ≥98% 438.49 C26H22N4O3 Ambient "Snyder DS, Tradtrantip L, Yao C, et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. PMID: 21707078.

 

Tradtrantip L, Sonawane ND, Namkung W, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. PMID: 19785436.

" Not dangerous goods.

LKT P6264 PPQ-102 25 mg 337.1 Pyramido-pyrrolo-quinoxalinedione; CFTR blocker. 931706-15-9 ≥98% 438.49 C26H22N4O3 Ambient "Snyder DS, Tradtrantip L, Yao C, et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. PMID: 21707078.

 

Tradtrantip L, Sonawane ND, Namkung W, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. PMID: 19785436.

" Not dangerous goods.

LKT A7604 ATB 346 1 mg 56.2 NSAID; COX inhibitor and HS-releasing agent. 1226895-20-0 365.45 C21H19NO3S "CC(c1ccc2cc(ccc2c1)OC)C(=O)Oc3ccc(cc3)C(=S)N

" Ambient "Dief AE, Mostafa DK, Sharara GM, et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1537-46. PMID: 25967731.

 

Herrera BS, Coimbra LS, da Silva AR, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4. PMID: 25755876.

 

Campolo M, Esposito E, Ahmad A, et al. Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. J Neuroinflammation. 2014 Dec 4;11:196. PMID: 25472548.

" Not dangerous goods.

LKT A7604 ATB 346 5 mg 168.5 NSAID; COX inhibitor and HS-releasing agent. 1226895-20-0 365.45 C21H19NO3S "CC(c1ccc2cc(ccc2c1)OC)C(=O)Oc3ccc(cc3)C(=S)N

" Ambient "Dief AE, Mostafa DK, Sharara GM, et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1537-46. PMID: 25967731.

 

Herrera BS, Coimbra LS, da Silva AR, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4. PMID: 25755876.

 

Campolo M, Esposito E, Ahmad A, et al. Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. J Neuroinflammation. 2014 Dec 4;11:196. PMID: 25472548.

" Not dangerous goods.

LKT A7604 ATB 346 25 mg 561.8 NSAID; COX inhibitor and HS-releasing agent. 1226895-20-0 365.45 C21H19NO3S "CC(c1ccc2cc(ccc2c1)OC)C(=O)Oc3ccc(cc3)C(=S)N

" Ambient "Dief AE, Mostafa DK, Sharara GM, et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1537-46. PMID: 25967731.

 

Herrera BS, Coimbra LS, da Silva AR, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4. PMID: 25755876.

 

Campolo M, Esposito E, Ahmad A, et al. Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. J Neuroinflammation. 2014 Dec 4;11:196. PMID: 25472548.

" Not dangerous goods.

LKT P7608 PTC124 5 mg 50.6 Read-through agent and nonsense mutation targeter. PTC-124, Ataluren, Translarna™ 775304-57-9 ≥98% 284.25 C15H9FN2O3 Ambient "Bushby K, Finkel R, Wong B, et al. Ataluren treatment of patients with nonsense mutation dystrophinopathy. Muscle Nerve. 2014 Oct;50(4):477-87. PMID: 25042182.

 

Ryan NJ. Ataluren: first global approval. Drugs. 2014 Sep;74(14):1709-14. PMID: 25193627.

 

Nagel-Wolfrum K, Möller F, Penner I, et al. Translational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations. Vis Neurosci. 2014 Sep;31(4-5):309-16. PMID: 24912600.

" Not dangerous goods.

LKT P7608 PTC124 25 mg 179.8 Read-through agent and nonsense mutation targeter. PTC-124, Ataluren, Translarna™ 775304-57-9 ≥98% 284.25 C15H9FN2O3 Ambient "Bushby K, Finkel R, Wong B, et al. Ataluren treatment of patients with nonsense mutation dystrophinopathy. Muscle Nerve. 2014 Oct;50(4):477-87. PMID: 25042182.

 

Ryan NJ. Ataluren: first global approval. Drugs. 2014 Sep;74(14):1709-14. PMID: 25193627.

 

Nagel-Wolfrum K, Möller F, Penner I, et al. Translational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations. Vis Neurosci. 2014 Sep;31(4-5):309-16. PMID: 24912600.

" Not dangerous goods.

LKT P7608 PTC124 100 mg 432.6 Read-through agent and nonsense mutation targeter. PTC-124, Ataluren, Translarna™ 775304-57-9 ≥98% 284.25 C15H9FN2O3 Ambient "Bushby K, Finkel R, Wong B, et al. Ataluren treatment of patients with nonsense mutation dystrophinopathy. Muscle Nerve. 2014 Oct;50(4):477-87. PMID: 25042182.

 

Ryan NJ. Ataluren: first global approval. Drugs. 2014 Sep;74(14):1709-14. PMID: 25193627.

 

Nagel-Wolfrum K, Möller F, Penner I, et al. Translational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations. Vis Neurosci. 2014 Sep;31(4-5):309-16. PMID: 24912600.

" Not dangerous goods.

LKT N1610 Necrostatin-1 5 mg 44.9 RIP1 inhibitor. 4311-88-0 259.33 C13H13N3OS Ambient "Zhu Y, Cui H, Gan H, et al. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 2015 Jun 12;461(4):575-81. PMID: 25907058.

 

Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015 Jun 3;1609:63-71. PMID: 25801119.

 

Steinwascher S, Nugues AL, Schoeneberger H, et al. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett. 2015 May 28. [Epub ahead of print]. PMID: 26028172.

" Not dangerous goods.

LKT N1610 Necrostatin-1 25 mg 112.4 RIP1 inhibitor. 4311-88-0 259.33 C13H13N3OS Ambient "Zhu Y, Cui H, Gan H, et al. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 2015 Jun 12;461(4):575-81. PMID: 25907058.

 

Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015 Jun 3;1609:63-71. PMID: 25801119.

 

Steinwascher S, Nugues AL, Schoeneberger H, et al. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett. 2015 May 28. [Epub ahead of print]. PMID: 26028172.

" Not dangerous goods.

LKT N1610 Necrostatin-1 100 mg 337.1 RIP1 inhibitor. 4311-88-0 259.33 C13H13N3OS Ambient "Zhu Y, Cui H, Gan H, et al. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 2015 Jun 12;461(4):575-81. PMID: 25907058.

 

Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015 Jun 3;1609:63-71. PMID: 25801119.

 

Steinwascher S, Nugues AL, Schoeneberger H, et al. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett. 2015 May 28. [Epub ahead of print]. PMID: 26028172.

" Not dangerous goods.

LKT C3214 CID-797718 5 mg 196.7 Potential PKD binding agent. 370586-05-3 ≥98% 217.22 C12H11NO3 Ambient Not dangerous goods.

LKT C3214 CID-797718 25 mg 584.2 Potential PKD binding agent. 370586-05-3 ≥98% 217.22 C12H11NO3 Ambient Not dangerous goods.

LKT P7000 PR-619 1 mg 39.4 Deubiquitinating enzyme inhibitor. 2645-32-1 223.27 C7H5N5S2 Ambient "Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.

 

Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.

 

Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.

" Not dangerous goods.

LKT P7000 PR-619 5 mg 84.3 Deubiquitinating enzyme inhibitor. 2645-32-1 223.27 C7H5N5S2 Ambient "Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.

 

Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.

 

Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.

" Not dangerous goods.

LKT P7000 PR-619 25 mg 196.7 Deubiquitinating enzyme inhibitor. 2645-32-1 223.27 C7H5N5S2 Ambient "Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.

 

Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.

 

Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.

" Not dangerous goods.

LKT K9200 KX1-004 1 mg 73.1 Indole; Src inhibitor. 518058-84-9 ≥98% 284.29 C16H13FN2O2 Ambient "Fetoni AR, Bielefeld EC, Paludetti G, et al. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Neurosci Res. 2014 Apr-May;81-82:30-7. PMID: 24472721.

 

Bielefeld EC, Hangauer D, Henderson D. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neurosci Res. 2011 Dec;71(4):348-54. PMID: 21840347.

 

Harris KC, Hu B, Hangauer D, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208(1-2):14-25. PMID: 15950415.

" Not dangerous goods.

LKT K9200 KX1-004 5 mg 207.9 Indole; Src inhibitor. 518058-84-9 ≥98% 284.29 C16H13FN2O2 Ambient "Fetoni AR, Bielefeld EC, Paludetti G, et al. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Neurosci Res. 2014 Apr-May;81-82:30-7. PMID: 24472721.

 

Bielefeld EC, Hangauer D, Henderson D. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neurosci Res. 2011 Dec;71(4):348-54. PMID: 21840347.

 

Harris KC, Hu B, Hangauer D, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208(1-2):14-25. PMID: 15950415.

" Not dangerous goods.

LKT K9200 KX1-004 25 mg 584.2 Indole; Src inhibitor. 518058-84-9 ≥98% 284.29 C16H13FN2O2 Ambient "Fetoni AR, Bielefeld EC, Paludetti G, et al. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Neurosci Res. 2014 Apr-May;81-82:30-7. PMID: 24472721.

 

Bielefeld EC, Hangauer D, Henderson D. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neurosci Res. 2011 Dec;71(4):348-54. PMID: 21840347.

 

Harris KC, Hu B, Hangauer D, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208(1-2):14-25. PMID: 15950415.

" Not dangerous goods.

LKT K6276 KPT-330 1 mg 56.2 CRM1-selective inhibitor of nuclear export. Selinexor 1421923-86-5 443.31 C17H11F6N7O "c1cnc(cn1)NNC(=O)C=Cn2cnc(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F

" Ambient "Ishizawa J, Kojima K, Hail N Jr, et al. Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther. 2015 Jun 3. [Epub ahead of print].  PMID: 26048327.

 

De Cesare M, Cominetti D, Doldi V, et al. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. 2015 May 30;6(15):13119-32. PMID: 25948791.

 

Parikh K, Cang S, Sekhri A, et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78. PMID: 25316614.

" Not dangerous goods.

LKT K6276 KPT-330 5 mg 185.4 CRM1-selective inhibitor of nuclear export. Selinexor 1421923-86-5 443.31 C17H11F6N7O "c1cnc(cn1)NNC(=O)C=Cn2cnc(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F

" Ambient "Ishizawa J, Kojima K, Hail N Jr, et al. Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther. 2015 Jun 3. [Epub ahead of print].  PMID: 26048327.

 

De Cesare M, Cominetti D, Doldi V, et al. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. 2015 May 30;6(15):13119-32. PMID: 25948791.

 

Parikh K, Cang S, Sekhri A, et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78. PMID: 25316614.

" Not dangerous goods.

LKT K6276 KPT-330 25 mg 561.8 CRM1-selective inhibitor of nuclear export. Selinexor 1421923-86-5 443.31 C17H11F6N7O "c1cnc(cn1)NNC(=O)C=Cn2cnc(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F

" Ambient "Ishizawa J, Kojima K, Hail N Jr, et al. Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther. 2015 Jun 3. [Epub ahead of print].  PMID: 26048327.

 

De Cesare M, Cominetti D, Doldi V, et al. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. 2015 May 30;6(15):13119-32. PMID: 25948791.

 

Parikh K, Cang S, Sekhri A, et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78. PMID: 25316614.

" Not dangerous goods.

LKT S0072 5S rRNA modificator 5 mg 134.8 Electrophile used in 2’-hydroxyl acylation of RNA. 2-Methyl-3-furoic acid imidazolide 1415238-77-5 ≥98% 176.18 C9H8N2O2 Ambient

LKT S0072 5S rRNA modificator 25 mg 337.1 Electrophile used in 2’-hydroxyl acylation of RNA. 2-Methyl-3-furoic acid imidazolide 1415238-77-5 ≥98% 176.18 C9H8N2O2 Ambient

LKT C4800 CM346 Hydrochloride 5 mg 110.1 Potential anxiolytic. Obenoxazine 173352-39-1 343.87 C15H21N3O2S HCl "CCOc1ccc2c(c1)[nH]c(n2)SCCN3CCOCC3.Cl

" Ambient

LKT C4800 CM346 Hydrochloride 25 mg 337.1 Potential anxiolytic. Obenoxazine 173352-39-1 343.87 C15H21N3O2S HCl "CCOc1ccc2c(c1)[nH]c(n2)SCCN3CCOCC3.Cl

" Ambient

LKT G0668 GBR 12935 Dihydrochloride 5 mg 44.9 DAT inhibitor. 67469-81-2 ≥98% 487.51 C28H36Cl2N2O Ambient "Root DH, Hoffman AF, Good CH, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25;35(8):3460-9. PMID: 25716845.

 

Zuo W, Chen L, Wang L, et al. Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons. Neuropharmacology. 2013 Jul;70:180-9. PMID: 23347950.

 

Janowsky A, Berger P, Vocci F, et al. Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. J Neurochem. 1986 Apr;46(4):1272-6. PMID: 3081686.

" Not dangerous goods.

LKT G0668 GBR 12935 Dihydrochloride 25 mg 151.7 DAT inhibitor. 67469-81-2 ≥98% 487.51 C28H36Cl2N2O Ambient "Root DH, Hoffman AF, Good CH, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25;35(8):3460-9. PMID: 25716845.

 

Zuo W, Chen L, Wang L, et al. Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons. Neuropharmacology. 2013 Jul;70:180-9. PMID: 23347950.

 

Janowsky A, Berger P, Vocci F, et al. Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. J Neurochem. 1986 Apr;46(4):1272-6. PMID: 3081686.

" Not dangerous goods.

LKT G0668 GBR 12935 Dihydrochloride 100 mg 539.3 DAT inhibitor. 67469-81-2 ≥98% 487.51 C28H36Cl2N2O Ambient "Root DH, Hoffman AF, Good CH, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25;35(8):3460-9. PMID: 25716845.

 

Zuo W, Chen L, Wang L, et al. Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons. Neuropharmacology. 2013 Jul;70:180-9. PMID: 23347950.

 

Janowsky A, Berger P, Vocci F, et al. Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. J Neurochem. 1986 Apr;46(4):1272-6. PMID: 3081686.

" Not dangerous goods.

LKT M7200 MS436 5 mg 134.8 BRD4 inhibitor. 1395084-25-9 383.43 C18H17N5O3S Ambient Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283. Not dangerous goods.

LKT M7200 MS436 25 mg 432.6 BRD4 inhibitor. 1395084-25-9 383.43 C18H17N5O3S Ambient Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283. Not dangerous goods.

LKT M7200 MS436 100 mg 1235.9 BRD4 inhibitor. 1395084-25-9 383.43 C18H17N5O3S Ambient Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283. Not dangerous goods.

LKT T5060 TMP-269 5 mg 168.5 HDAC inhibitor. 1314890-29-3 514.52 C25H21F3N4O3S Ambient "Kikuchi S, Suzuki R, Ohguchi H, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Mar 24. [Epub ahead of print]. PMID: 25801913.

 

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

" Not dangerous goods.

LKT T5060 TMP-269 10 mg 280.9 HDAC inhibitor. 1314890-29-3 514.52 C25H21F3N4O3S Ambient "Kikuchi S, Suzuki R, Ohguchi H, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Mar 24. [Epub ahead of print]. PMID: 25801913.

 

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

" Not dangerous goods.

LKT T5060 TMP-269 25 mg 584.2 HDAC inhibitor. 1314890-29-3 514.52 C25H21F3N4O3S Ambient "Kikuchi S, Suzuki R, Ohguchi H, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Mar 24. [Epub ahead of print]. PMID: 25801913.

 

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

" Not dangerous goods.

LKT K0552 Kb NB 77-78 5 mg 140.5 CID-797718 analog; potential PKD1 binding agent. 1350622-33-1 ≥98% 331.49 C18H25NO3Si Ambient Not dangerous goods.

LKT K0552 Kb NB 77-78 10 mg 252.8 CID-797718 analog; potential PKD1 binding agent. 1350622-33-1 ≥98% 331.49 C18H25NO3Si Ambient Not dangerous goods.

LKT K0552 Kb NB 77-78 25 mg 505.6 CID-797718 analog; potential PKD1 binding agent. 1350622-33-1 ≥98% 331.49 C18H25NO3Si Ambient Not dangerous goods.

LKT N1894 Nexturastat A 1 mg 110.1 HDAC6 inhibitor. 1403783-31-2 ≥98% 341.41 C19H23N3O3 Ambient Woan KV, Lienlaf M, Perez-Villaroel P, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol. 2015 Apr 24. [Epub ahead of print]. PMID: 25957812. Not dangerous goods.

LKT N1894 Nexturastat A 5 mg 443.8 HDAC6 inhibitor. 1403783-31-2 ≥98% 341.41 C19H23N3O3 Ambient Woan KV, Lienlaf M, Perez-Villaroel P, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol. 2015 Apr 24. [Epub ahead of print]. PMID: 25957812. Not dangerous goods.

LKT N1894 Nexturastat A 10 mg 769.7 HDAC6 inhibitor. 1403783-31-2 ≥98% 341.41 C19H23N3O3 Ambient Woan KV, Lienlaf M, Perez-Villaroel P, et al. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol. 2015 Apr 24. [Epub ahead of print]. PMID: 25957812. Not dangerous goods.

LKT L2800 LH846 5 mg 76.4 Casein kinase 1α/δ/ε inhibitor. 639052-78-1 316.8 C16H13ClN2OS Ambient Lee JW, Hirota T, Peters EC, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. PMID: 21954091. Not dangerous goods.

LKT L2800 LH846 25 mg 320.3 Casein kinase 1α/δ/ε inhibitor. 639052-78-1 316.8 C16H13ClN2OS Ambient Lee JW, Hirota T, Peters EC, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. PMID: 21954091. Not dangerous goods.

LKT J0240 JAK2 Inhibitor V 5 mg 73.1 JAK2 inhibitor. JAK2 inhibitor V, Z3 195371-52-9 344.46 C23H24N2O Ambient Sayyah J, Magis A, Ostrov DA, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther. 2008 Aug;7(8):2308-18. PMID: 18723478. Not dangerous goods.

LKT J0240 JAK2 Inhibitor V 25 mg 252.8 JAK2 inhibitor. JAK2 inhibitor V, Z3 195371-52-9 344.46 C23H24N2O Ambient Sayyah J, Magis A, Ostrov DA, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther. 2008 Aug;7(8):2308-18. PMID: 18723478. Not dangerous goods.

LKT B6902 B-Raf IN 1 1 mg 134.8 B-Raf and c-Raf inhibitor. 950736-05-7 ≥98% 515.54 C29H24F3N5O Ambient Berger DM, Torres N, Dutia M, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. PMID: 19864136. Not dangerous goods.

LKT B6902 B-Raf IN 1 5 mg 432.6 B-Raf and c-Raf inhibitor. 950736-05-7 ≥98% 515.54 C29H24F3N5O Ambient Berger DM, Torres N, Dutia M, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. PMID: 19864136. Not dangerous goods.

LKT B6902 B-Raf IN 1 10 mg 674.1 B-Raf and c-Raf inhibitor. 950736-05-7 ≥98% 515.54 C29H24F3N5O Ambient Berger DM, Torres N, Dutia M, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. PMID: 19864136. Not dangerous goods.

LKT R5700 Ro 61-8048 5 mg 84.3 Kynurenine 3-hydroxylase inhibitor. 199666-03-0 421.44 C17H15N3O6S2 Ambient "Pisar M, Forrest CM, Khalil OS, et al. Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway. Brain Res. 2014 Aug 12;1576:1-17. PMID: 24956103.

 

Ouattara B, Belkhir S, Morissette M, et al. Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. J Mol Neurosci. 2009 Jun;38(2):128-42. PMID: 18704766.

 

Rodgers J, Stone TW, Barrett MP, et al. Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain. 2009 May;132(Pt 5):1259-67. PMID: 19339256.

" Not dangerous goods.

LKT R5700 Ro 61-8048 25 mg 280.9 Kynurenine 3-hydroxylase inhibitor. 199666-03-0 421.44 C17H15N3O6S2 Ambient "Pisar M, Forrest CM, Khalil OS, et al. Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway. Brain Res. 2014 Aug 12;1576:1-17. PMID: 24956103.

 

Ouattara B, Belkhir S, Morissette M, et al. Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. J Mol Neurosci. 2009 Jun;38(2):128-42. PMID: 18704766.

 

Rodgers J, Stone TW, Barrett MP, et al. Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain. 2009 May;132(Pt 5):1259-67. PMID: 19339256.

" Not dangerous goods.

LKT W2800 WH-4-023 5 mg 168.5 Lck, Src, SIK inhibitor. KIN112 837422-57-8 568.68 C32H36N6O4 Ambient "Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. PMID: 23033494.

 

Martin MW, Newcomb J, Nunes JJ, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (WH-4-023)"

LKT W2800 WH-4-023 25 mg 505.6 Lck, Src, SIK inhibitor. KIN112 837422-57-8 568.68 C32H36N6O4 Ambient "Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. PMID: 23033494.

 

Martin MW, Newcomb J, Nunes JJ, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (WH-4-023)"

LKT Z4552 ZLN005 10 mg 56.2 PPARγ coactivator-1α expression stimulator. 49671-76-3 250.35 C17H18N2 Ambient Zhang LN, Zhou HY, Fu YY, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307. PMID: 23250358. Not dangerous goods.

LKT Z4552 ZLN005 50 mg 230.4 PPARγ coactivator-1α expression stimulator. 49671-76-3 250.35 C17H18N2 Ambient Zhang LN, Zhou HY, Fu YY, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307. PMID: 23250358. Not dangerous goods.

LKT K5606 Kobe 2602 10 mg 39.4 Ras inhibitor. 454453-49-7 419.31 C14H9F4N5O4S Ambient "Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.

 

Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.

" Not dangerous goods.

LKT K5606 Kobe 2602 50 mg 118 Ras inhibitor. 454453-49-7 419.31 C14H9F4N5O4S Ambient "Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.

 

Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.

" Not dangerous goods.

LKT K5606 Kobe 2602 100 mg 213.5 Ras inhibitor. 454453-49-7 419.31 C14H9F4N5O4S Ambient "Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.

 

Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.

" Not dangerous goods.

LKT J3204 E-JIB-04 5 mg 78.6 Jumonji histone demethylase inhibitor. (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine NSC 693627, JHDM inhibitor VII 199596-05-9 308.77 C17H13ClN4 Ambient "Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

 

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639.  PMID: 23792809.

" Not dangerous goods.

LKT J3204 E-JIB-04 25 mg 269.6 Jumonji histone demethylase inhibitor. (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine NSC 693627, JHDM inhibitor VII 199596-05-9 308.77 C17H13ClN4 Ambient "Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

 

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639.  PMID: 23792809.

" Not dangerous goods.

LKT J3205 Z-JIB-04 5 mg 84.3 Jumonji histone demethylase inhibitor. NSC 693627 199596-24-2 308.77 C17H13ClN4 Ambient "Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

 

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639.  PMID: 23792809.

" Not dangerous goods.

LKT J3205 Z-JIB-04 25 mg 280.9 Jumonji histone demethylase inhibitor. NSC 693627 199596-24-2 308.77 C17H13ClN4 Ambient "Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

 

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639.  PMID: 23792809.

" Not dangerous goods.

LKT W7201 WS6 5 mg 101.1 Islet α/β cell proliferation stimulator. 1421227-53-3 568.6 C29H31F3N6O3 Ambient "Boerner BP, George NM, Mir SU, et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86. PMID: 25739404.

 

Shen W, Tremblay MS, Deshmukh VA, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573.  PMID: 23330637.

" Not dangerous goods.

LKT W7201 WS6 25 mg 325.8 Islet α/β cell proliferation stimulator. 1421227-53-3 568.6 C29H31F3N6O3 Ambient "Boerner BP, George NM, Mir SU, et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J. 2015;62(4):379-86. PMID: 25739404.

 

Shen W, Tremblay MS, Deshmukh VA, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573.  PMID: 23330637.

" Not dangerous goods.

LKT W7200 WS3 5 mg 101.1 Islet β cell proliferation stimulator. 1421227-52-2 569.59 C28H30F3N7O3 Ambient "Swoboda JG, Elliott J, Deshmukh V, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. PMID: 23621521.

 

Shen W, Tremblay MS, Deshmukh VA, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573.  PMID: 23330637.

" Not dangerous goods.

LKT W7200 WS3 25 mg 331.5 Islet β cell proliferation stimulator. 1421227-52-2 569.59 C28H30F3N7O3 Ambient "Swoboda JG, Elliott J, Deshmukh V, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. PMID: 23621521.

 

Shen W, Tremblay MS, Deshmukh VA, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. Erratum in: J Am Chem Soc. 2013 Mar 20;135(11):4573.  PMID: 23330637.

" Not dangerous goods.

LKT L0400 LB-100 5 mg 168.5 PP2A inhibitor. 1026680-07-8 ≥98% 268.31 C13H20N2O4 Ambient "Bai X, Zhi X, Zhang Q, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Dec 28;355(2):281-7. PMID: 25304380.

 

Bai XL, Zhang Q, Ye LY, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72. PMID: 24867249.

" "UN number: 3077    Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (LB100)"

LKT L0400 LB-100 25 mg 539.3 PP2A inhibitor. 1026680-07-8 ≥98% 268.31 C13H20N2O4 Ambient "Bai X, Zhi X, Zhang Q, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Dec 28;355(2):281-7. PMID: 25304380.

 

Bai XL, Zhang Q, Ye LY, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72. PMID: 24867249.

" "UN number: 3077    Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (LB100)"

LKT M1335 Mdivi-1 5 mg 50.6 Quinazolinone; mitochondrial division inhibitor. 338967-87-6 353.2 C15H10Cl2N2O2S Ambient "Li G, Jia Z, Cao Y, et al. Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats. Neurochem Res. 2015 May 13. [Epub ahead of print]. PMID: 25968480.

 

Liu JM, Yi Z, Liu SZ, et al. The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channels. Brain Res. 2015 Mar 24. [Epub ahead of print]. PMID: 25818100.

 

Sharp WW, Beiser DG, Fang YH, et al. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb;43(2):e38-47. PMID: 25599491.

 

Han XJ, Yang ZJ, Jiang LP, et al. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 2015 Feb;46(2):691-700. PMID: 25434519.

" Not dangerous goods.

LKT M1335 Mdivi-1 25 mg 202.2 Quinazolinone; mitochondrial division inhibitor. 338967-87-6 353.2 C15H10Cl2N2O2S Ambient "Li G, Jia Z, Cao Y, et al. Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats. Neurochem Res. 2015 May 13. [Epub ahead of print]. PMID: 25968480.

 

Liu JM, Yi Z, Liu SZ, et al. The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channels. Brain Res. 2015 Mar 24. [Epub ahead of print]. PMID: 25818100.

 

Sharp WW, Beiser DG, Fang YH, et al. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb;43(2):e38-47. PMID: 25599491.

 

Han XJ, Yang ZJ, Jiang LP, et al. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 2015 Feb;46(2):691-700. PMID: 25434519.

" Not dangerous goods.

LKT R2788 RGW-611 5 mg 50.6 Morpholine derivative. 6497-78-5 ≥98% 226.24 C9H14N4O3 Ambient Not dangerous goods.

LKT R2788 RGW-611 25 mg 202.2 Morpholine derivative. 6497-78-5 ≥98% 226.24 C9H14N4O3 Ambient Not dangerous goods.

LKT C4418 Clemizole Hydrochloride 5 mg 61.8 TRPC5, NS4B, histamine H1 inhibitor. 1163-36-6 ≥98% 362.3 C19H21Cl2N3 "c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4.Cl

" Ambient "Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

 

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

 

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

 

Martínez-Mir MI, Estañ L, Morales-Olivas FJ, et al. Effect of histamine and histamine analogues on human isolated myometrial strips. Br J Pharmacol. 1992 Oct;107(2):528-31. PMID: 1358393.

" Not dangerous goods.

LKT C4418 Clemizole Hydrochloride 25 mg 224.7 TRPC5, NS4B, histamine H1 inhibitor. 1163-36-6 ≥98% 362.3 C19H21Cl2N3 "c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4.Cl

" Ambient "Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

 

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

 

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

 

Martínez-Mir MI, Estañ L, Morales-Olivas FJ, et al. Effect of histamine and histamine analogues on human isolated myometrial strips. Br J Pharmacol. 1992 Oct;107(2):528-31. PMID: 1358393.

" Not dangerous goods.

LKT L9800 LY-364947 5 mg 95.6 ALK5 (activin-like) inhibitor. LY364947 396129-53-6 272.31 C17H12N4 Ambient "Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.

 

Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (LY364947)"

LKT L9800 LY-364947 25 mg 337.1 ALK5 (activin-like) inhibitor. LY364947 396129-53-6 272.31 C17H12N4 Ambient "Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.

 

Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (LY364947)"

LKT J0001 J-147 5 mg 44.9 Phenyl hydrazide; neuronal oxidative stress inhibitor. 1146963-51-0 350.34 C18H17F3N2O2 Ambient "Chen HY, Xu DP, Tan GL, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 May 17. [Epub ahead of print]. PMID: 25982925.

 

Prior M, Dargusch R, Ehren JL, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. PMID: 23673233.

 

Chiruta C, Zhao Y, Tang F, et al. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. PMID: 23582448.

" Not dangerous goods.

LKT J0001 J-147 25 mg 140.5 Phenyl hydrazide; neuronal oxidative stress inhibitor. 1146963-51-0 350.34 C18H17F3N2O2 Ambient "Chen HY, Xu DP, Tan GL, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 May 17. [Epub ahead of print]. PMID: 25982925.

 

Prior M, Dargusch R, Ehren JL, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. PMID: 23673233.

 

Chiruta C, Zhao Y, Tang F, et al. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. PMID: 23582448.

" Not dangerous goods.

LKT J0001 J-147 100 mg 337.1 Phenyl hydrazide; neuronal oxidative stress inhibitor. 1146963-51-0 350.34 C18H17F3N2O2 Ambient "Chen HY, Xu DP, Tan GL, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 May 17. [Epub ahead of print]. PMID: 25982925.

 

Prior M, Dargusch R, Ehren JL, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. PMID: 23673233.

 

Chiruta C, Zhao Y, Tang F, et al. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. PMID: 23582448.

" Not dangerous goods.

LKT A2401 AG-18 5 mg 39.4 EGFR and PDGFR inhibitor Tyrphostin A23 118409-57-7 ≥98% 186.17 C10H6N2O2 "c1cc(c(cc1C=C(C#N)C#N)O)O

" Ambient "Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.

 

Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.

" Not dangerous goods.

LKT A2401 AG-18 25 mg 151.7 EGFR and PDGFR inhibitor Tyrphostin A23 118409-57-7 ≥98% 186.17 C10H6N2O2 "c1cc(c(cc1C=C(C#N)C#N)O)O

" Ambient "Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.

 

Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.

" Not dangerous goods.

LKT C0824 CCG1423 5 mg 73.1 Serum response factor inhibitor and MRTF-A binding agent. 285986-88-1 454.75 C18H13ClF6N2O3 Ambient "Hayashi K, Watanabe B, Nakagawa Y, et al. RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. PLoS One. 2014 Feb 18;9(2):e89016. PMID: 24558465.

 

Bell JL, Haak AJ, Wade SM, et al. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. PMID: 23707258.

 

Jin W, Goldfine AB, Boes T, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29. PMID: 21393865.

" Not dangerous goods.

LKT C0824 CCG1423 25 mg 252.8 Serum response factor inhibitor and MRTF-A binding agent. 285986-88-1 454.75 C18H13ClF6N2O3 Ambient "Hayashi K, Watanabe B, Nakagawa Y, et al. RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. PLoS One. 2014 Feb 18;9(2):e89016. PMID: 24558465.

 

Bell JL, Haak AJ, Wade SM, et al. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. PMID: 23707258.

 

Jin W, Goldfine AB, Boes T, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29. PMID: 21393865.

" Not dangerous goods.

LKT S7601 Statil 5 mg 110.1 Aldose reductase inhibitor. 72702-95-5 391.2 C17H12BrFN2O3 "c1ccc2c(c1)c(nn(c2=O)Cc3ccc(cc3F)Br)CC(=O)O

" Ambient "Pastel E, Pointud JC, Loubeau G, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84. PMID: 25730106.

 

Cao Z, Zhou B, Chen X, et al. Statil suppresses cancer cell growth and proliferation by the inhibition of tumor marker AKR1B10. Anticancer Drugs. 2014 Sep;25(8):930-7. PMID: 24800887.

 

El-Kabbani O, Ramsland P, Darmanin C, et al. Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme. Proteins. 2003 Feb 1;50(2):230-8. PMID: 12486717.

" Not dangerous goods.

LKT S7601 Statil 25 mg 393.2 Aldose reductase inhibitor. 72702-95-5 391.2 C17H12BrFN2O3 "c1ccc2c(c1)c(nn(c2=O)Cc3ccc(cc3F)Br)CC(=O)O

" Ambient "Pastel E, Pointud JC, Loubeau G, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84. PMID: 25730106.

 

Cao Z, Zhou B, Chen X, et al. Statil suppresses cancer cell growth and proliferation by the inhibition of tumor marker AKR1B10. Anticancer Drugs. 2014 Sep;25(8):930-7. PMID: 24800887.

 

El-Kabbani O, Ramsland P, Darmanin C, et al. Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme. Proteins. 2003 Feb 1;50(2):230-8. PMID: 12486717.

" Not dangerous goods.

LKT S7061 SRPIN340 5 mg 84.3 SRPK1 inhibitor. SRPIN 340 218156-96-8 ≥98% 349.36 C18H18F3N3O Ambient "Gammons MV, Lucas R, Dean R, et al. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma. Br J Cancer. 2014 Jul 29;111(3):477-85. PMID: 25010863.

 

Gammons MV, Dick AD, Harper SJ, et al. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5797-806. PMID: 23761094.

 

Karakama Y, Sakamoto N, Itsui Y, et al. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 2010 Aug;54(8):3179-86. PMID: 20498328.

" Not dangerous goods.

LKT S7061 SRPIN340 25 mg 325.8 SRPK1 inhibitor. SRPIN 340 218156-96-8 ≥98% 349.36 C18H18F3N3O Ambient "Gammons MV, Lucas R, Dean R, et al. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma. Br J Cancer. 2014 Jul 29;111(3):477-85. PMID: 25010863.

 

Gammons MV, Dick AD, Harper SJ, et al. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5797-806. PMID: 23761094.

 

Karakama Y, Sakamoto N, Itsui Y, et al. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 2010 Aug;54(8):3179-86. PMID: 20498328.

" Not dangerous goods.

LKT C7992 CTX-0294885 5 mg 123.6 Bisaniline pyrimidine; pan-kinase inhibitor. 1439934-41-4 ≥98% 437.93 C22H24ClN7O Ambient Zhang L, Holmes IP, Hochgräfe F, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16. PMID: 23692254. Not dangerous goods.

LKT C7992 CTX-0294885 25 mg 393.2 Bisaniline pyrimidine; pan-kinase inhibitor. 1439934-41-4 ≥98% 437.93 C22H24ClN7O Ambient Zhang L, Holmes IP, Hochgräfe F, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16. PMID: 23692254. Not dangerous goods.

LKT T0216 TAE-226 5 mg 185.4 FAK inhibitor. NVP-TAE226 761437-28-9 468.94 C23H25ClN6O3 Ambient "Dao P, Jarray R, Le Coq J, et al. Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4552-6. PMID: 23845217.

 

Golubovskaya VM, Ho B, Zheng M, et al. Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities. Anticancer Agents Med Chem. 2013 May;13(4):546-54. PMID: 22292772.

 

Bhavaraju K, Lakhani PR, Dorsam RT, et al. G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets. PLoS One. 2011 Feb 10;6(2):e16586. PMID: 21347357.

" Not dangerous goods.

LKT T0216 TAE-226 25 mg 589.9 FAK inhibitor. NVP-TAE226 761437-28-9 468.94 C23H25ClN6O3 Ambient "Dao P, Jarray R, Le Coq J, et al. Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4552-6. PMID: 23845217.

 

Golubovskaya VM, Ho B, Zheng M, et al. Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities. Anticancer Agents Med Chem. 2013 May;13(4):546-54. PMID: 22292772.

 

Bhavaraju K, Lakhani PR, Dorsam RT, et al. G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets. PLoS One. 2011 Feb 10;6(2):e16586. PMID: 21347357.

" Not dangerous goods.

LKT G7200 GS-967 5 mg 134.8 Na+ channel blocker. 1262618-39-2 347.22 C14H7F6N3O Ambient "Anderson LL, Thompson CH, Hawkins NA, et al. Antiepileptic activity of preferential inhibitors of persistent sodium current. Epilepsia. 2014 Aug;55(8):1274-83. PMID: 24862204.

 

Pezhouman A, Madahian S, Stepanyan H, et al. Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart Rhythm. 2014 Mar;11(3):492-501. PMID: 24291413.

 

Sicouri S, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm. 2013 Jul;10(7):1036-43. PMID: 23524321.

" Not dangerous goods.

LKT G7200 GS-967 25 mg 421.4 Na+ channel blocker. 1262618-39-2 347.22 C14H7F6N3O Ambient "Anderson LL, Thompson CH, Hawkins NA, et al. Antiepileptic activity of preferential inhibitors of persistent sodium current. Epilepsia. 2014 Aug;55(8):1274-83. PMID: 24862204.

 

Pezhouman A, Madahian S, Stepanyan H, et al. Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart Rhythm. 2014 Mar;11(3):492-501. PMID: 24291413.

 

Sicouri S, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm. 2013 Jul;10(7):1036-43. PMID: 23524321.

" Not dangerous goods.

LKT G7862 GTPL-5846 5 mg 95.6 GPR84 agonist. 6-n-octylaminouracil; 6-OAU 83797-69-7 ≥98% 239.32 C12H21N3O2 Ambient Suzuki M, Takaishi S, Nagasaki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. PMID: 23449982. Not dangerous goods.

LKT G7862 GTPL-5846 25 mg 337.1 GPR84 agonist. 6-n-octylaminouracil; 6-OAU 83797-69-7 ≥98% 239.32 C12H21N3O2 Ambient Suzuki M, Takaishi S, Nagasaki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. PMID: 23449982. Not dangerous goods.

LKT T3461 Tiplaxtinin 5 mg 163 PAI-1 inhibitor. PAI-039 393105-53-8 439.39 C24H16F3NO4 "c1ccc(cc1)Cn2cc(c3c2ccc(c3)c4ccc(cc4)OC(F)(F)F)C(=O)C(=O)O

" Ambient "Simone TM, Longmate WM, Law BK, et al. Targeted Inhibition of PAI-1 Activity Impairs Epithelial Migration and Wound Closure Following Cutaneous Injury. Adv Wound Care (New Rochelle). 2015 Jun 1;4(6):321-328. PMID: 26029482.

 

Simone TM, Higgins SP, Archambeault J, et al. A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell Signal. 2015 May;27(5):923-33. PMID: 25617690.

 

Gomes-Giacoia E, Miyake M, Goodison S, et al. Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther. 2013 Dec;12(12):2697-708. PMID: 24072883.

 

Lee SH, Eren M, Vaughan DE, et al. A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma. Am J Respir Cell Mol Biol. 2012 Jun;46(6):842-6. PMID: 22323366.

" Not dangerous goods.

LKT T3461 Tiplaxtinin 25 mg 505.6 PAI-1 inhibitor. PAI-039 393105-53-8 439.39 C24H16F3NO4 "c1ccc(cc1)Cn2cc(c3c2ccc(c3)c4ccc(cc4)OC(F)(F)F)C(=O)C(=O)O

" Ambient "Simone TM, Longmate WM, Law BK, et al. Targeted Inhibition of PAI-1 Activity Impairs Epithelial Migration and Wound Closure Following Cutaneous Injury. Adv Wound Care (New Rochelle). 2015 Jun 1;4(6):321-328. PMID: 26029482.

 

Simone TM, Higgins SP, Archambeault J, et al. A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell Signal. 2015 May;27(5):923-33. PMID: 25617690.

 

Gomes-Giacoia E, Miyake M, Goodison S, et al. Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther. 2013 Dec;12(12):2697-708. PMID: 24072883.

 

Lee SH, Eren M, Vaughan DE, et al. A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma. Am J Respir Cell Mol Biol. 2012 Jun;46(6):842-6. PMID: 22323366.

" Not dangerous goods.

LKT M3196 MHY-1485 5 mg 56.2 mTOR activator. 326914-06-1 ≥98% 387.4 C17H21N7O4 Ambient "Li C, Siragy HM. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015 Jun 16. [Epub ahead of print]. PMID: 26081285.

 

Cheng Y, Kim J, Li XX, et al. Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators. PLoS One. 2015 Feb 24;10(2):e0117769. PMID: 25710488.

 

Choi YJ, Park YJ, Park JY, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7(8):e43418. Erratum in: PLoS One. 2013;8(1). PMID: 22927967.

" Not dangerous goods.

LKT M3196 MHY-1485 25 mg 224.7 mTOR activator. 326914-06-1 ≥98% 387.4 C17H21N7O4 Ambient "Li C, Siragy HM. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015 Jun 16. [Epub ahead of print]. PMID: 26081285.

 

Cheng Y, Kim J, Li XX, et al. Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators. PLoS One. 2015 Feb 24;10(2):e0117769. PMID: 25710488.

 

Choi YJ, Park YJ, Park JY, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7(8):e43418. Erratum in: PLoS One. 2013;8(1). PMID: 22927967.

" Not dangerous goods.

LKT N2400 NG-52 1 mg 56.2 Purine, purvalenol A analog; CDK2, Cdc28p, Pho85p inhibitor. 212779-48-1 ≥98% 346.81 C16H19ClN6O Ambient Gray NS, Wodicka L, Thunnissen AM, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. PMID: 9677190. Not dangerous goods.

LKT N2400 NG-52 5 mg 224.7 Purine, purvalenol A analog; CDK2, Cdc28p, Pho85p inhibitor. 212779-48-1 ≥98% 346.81 C16H19ClN6O Ambient Gray NS, Wodicka L, Thunnissen AM, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. PMID: 9677190. Not dangerous goods.

LKT N2400 NG-52 25 mg 730.3 Purine, purvalenol A analog; CDK2, Cdc28p, Pho85p inhibitor. 212779-48-1 ≥98% 346.81 C16H19ClN6O Ambient Gray NS, Wodicka L, Thunnissen AM, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. PMID: 9677190. Not dangerous goods.

LKT A2500 AG-1478 5 mg 95.6 EGFR inhibitor. Tyrphostin AG1478, NSC693255 153436-53-4 315.76 C16H14ClN3O2 Ambient "Parker JC, Douglas I, Bell J, et al. Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. PLoS One. 2015 Jun 9;10(6):e0129546. PMID: 26057128.

 

Bondì ML, Azzolina A, Craparo EF, et al. Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells. J Nanobiotechnology. 2014 May 12;12:21. PMID: 24886097.

 

Shimizu S, Kouzaki H, Ogawa T, et al. Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling. Am J Rhinol Allergy. 2014 Mar-Apr;28(2):103-9. PMID: 24717945.

" Not dangerous goods.

LKT A2500 AG-1478 25 mg 337.1 EGFR inhibitor. Tyrphostin AG1478, NSC693255 153436-53-4 315.76 C16H14ClN3O2 Ambient "Parker JC, Douglas I, Bell J, et al. Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. PLoS One. 2015 Jun 9;10(6):e0129546. PMID: 26057128.

 

Bondì ML, Azzolina A, Craparo EF, et al. Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells. J Nanobiotechnology. 2014 May 12;12:21. PMID: 24886097.

 

Shimizu S, Kouzaki H, Ogawa T, et al. Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling. Am J Rhinol Allergy. 2014 Mar-Apr;28(2):103-9. PMID: 24717945.

" Not dangerous goods.

LKT A2501 AG-1517 5 mg 95.6 EGFR inhibitor. Tyrphostin AG1517; PD153035; SU5271 153436-54-5 360.21 C16H14BrN3O2 "COc1cc2c(cc1OC)ncnc2Nc3cccc(c3)Br

" Ambient "Zhang Z, Oyesanya RA, Campbell DJ, et al. Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. Hepatology. 2010 Sep;52(3):975-86. PMID: 20607690.

 

Powell TJ, Ben-Bassat H, Klein BY, et al. Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors. Br J Dermatol. 1999 Nov;141(5):802-10. PMID: 10583160.

" Not dangerous goods.

LKT A2501 AG-1517 25 mg 337.1 EGFR inhibitor. Tyrphostin AG1517; PD153035; SU5271 153436-54-5 360.21 C16H14BrN3O2 "COc1cc2c(cc1OC)ncnc2Nc3cccc(c3)Br

" Ambient "Zhang Z, Oyesanya RA, Campbell DJ, et al. Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. Hepatology. 2010 Sep;52(3):975-86. PMID: 20607690.

 

Powell TJ, Ben-Bassat H, Klein BY, et al. Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors. Br J Dermatol. 1999 Nov;141(5):802-10. PMID: 10583160.

" Not dangerous goods.

LKT B5728 Bohemine 5 mg 140.5 Purine derivative; CDK inhibitor. 189232-42-6 ≥98% 340.43 C18H24N6O Ambient "Kovarova H, Halada P, Man P, et al. Application of proteomics in the search for novel proteins associated with the anti-cancer effect of the synthetic cyclin-dependent kinases inhibitor, bohemine. Technol Cancer Res Treat. 2002 Aug;1(4):247-56. PMID: 12625783.

 

Franek F, Strnad M, Havlícek L, et al. Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture. Cytotechnology. 2001 Jul;36(1-3):117-23. PMID: 19003322.

" Not dangerous goods.

LKT B5728 Bohemine 25 mg 477.5 Purine derivative; CDK inhibitor. 189232-42-6 ≥98% 340.43 C18H24N6O Ambient "Kovarova H, Halada P, Man P, et al. Application of proteomics in the search for novel proteins associated with the anti-cancer effect of the synthetic cyclin-dependent kinases inhibitor, bohemine. Technol Cancer Res Treat. 2002 Aug;1(4):247-56. PMID: 12625783.

 

Franek F, Strnad M, Havlícek L, et al. Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture. Cytotechnology. 2001 Jul;36(1-3):117-23. PMID: 19003322.

" Not dangerous goods.

LKT C9808 CZC-54252 5 mg 157.3 LRRK2 inhibitor. 1191911-27-9 504.99 C22H25ClN6O4S Ambient "Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.

 

Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.

" Not dangerous goods.

LKT C9808 CZC-54252 25 mg 556.2 LRRK2 inhibitor. 1191911-27-9 504.99 C22H25ClN6O4S Ambient "Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.

 

Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.

" Not dangerous goods.

LKT N7200 NS-11394 5 mg 163 GABA-A α5/3/2 positive modulator. 951650-22-9 353.43 C23H19N3O "CC(C)(c1ccc2c(c1)ncn2c3cccc(c3)c4ccccc4C#N)O

" Ambient "Hofmann M, Kordás KS, Gravius A, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behav Pharmacol. 2012 Dec;23(8):790-801. Erratum in: Behav Pharmacol. 2013 Apr;24(2):153.  PMID: 23075708.

 

Hansen RR, Erichsen HK, Brown DT, et al. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats. Neuropharmacology. 2012 Dec;63(8):1360-7. PMID: 22985969.

 

Mirza NR, Larsen JS, Mathiasen C, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68. PMID: 18791063.

" Not dangerous goods.

LKT N7200 NS-11394 25 mg 561.8 GABA-A α5/3/2 positive modulator. 951650-22-9 353.43 C23H19N3O "CC(C)(c1ccc2c(c1)ncn2c3cccc(c3)c4ccccc4C#N)O

" Ambient "Hofmann M, Kordás KS, Gravius A, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behav Pharmacol. 2012 Dec;23(8):790-801. Erratum in: Behav Pharmacol. 2013 Apr;24(2):153.  PMID: 23075708.

 

Hansen RR, Erichsen HK, Brown DT, et al. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats. Neuropharmacology. 2012 Dec;63(8):1360-7. PMID: 22985969.

 

Mirza NR, Larsen JS, Mathiasen C, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68. PMID: 18791063.

" Not dangerous goods.

LKT K0652 Kb NB 142-70 5 mg 110.1 PKD inhibitor. 1233533-04-4 ≥98% 251.32 C11H9NO2S2 Ambient "Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

 

Ni Y, Sinnett-Smith J, Young SH, et al. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One. 2013 Sep 9;8(9):e73149. Erratum in: PLoS One. 2014;9(1). PMID: 24039875.

 

Young SH, Rozengurt N, Sinnett-Smith J, et al. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. PMID: 22595992.

" Not dangerous goods.

LKT K0652 Kb NB 142-70 25 mg 393.2 PKD inhibitor. 1233533-04-4 ≥98% 251.32 C11H9NO2S2 Ambient "Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.

 

Ni Y, Sinnett-Smith J, Young SH, et al. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One. 2013 Sep 9;8(9):e73149. Erratum in: PLoS One. 2014;9(1). PMID: 24039875.

 

Young SH, Rozengurt N, Sinnett-Smith J, et al. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. PMID: 22595992.

" Not dangerous goods.

LKT C0273 Casin 5 mg 106.8 Cdc42 GTPase inhibitor. 425399-05-9 ≥98% 306.41 C20H22N2O Ambient "Florian MC, Dörr K, Niebel A, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 2012 May 4;10(5):520-30. PMID: 22560076.

 

Peterson JR, Lebensohn AM, Pelish HE, et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol. 2006 Apr;13(4):443-52. PMID: 16632257.

" Not dangerous goods.

LKT C0273 Casin 25 mg 393.2 Cdc42 GTPase inhibitor. 425399-05-9 ≥98% 306.41 C20H22N2O Ambient "Florian MC, Dörr K, Niebel A, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 2012 May 4;10(5):520-30. PMID: 22560076.

 

Peterson JR, Lebensohn AM, Pelish HE, et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol. 2006 Apr;13(4):443-52. PMID: 16632257.

" Not dangerous goods.

LKT F1992 Fexaramine 5 mg 129.3 FXR agonist. 574013-66-4 ≥98% 496.65 C32H36N2O3 "CN(C)c1ccc(cc1)c2ccc(cc2)CN(c3cccc(c3)C=CC(=O)OC)C(=O)C4CCCCC4

" Ambient "Fang S, Suh JM, Reilly SM, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65. PMID: 25559344.

 

Downes M, Verdecia MA, Roecker AJ, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92. PMID: 12718892.

" Not dangerous goods.

LKT F1992 Fexaramine 25 mg 449.4 FXR agonist. 574013-66-4 ≥98% 496.65 C32H36N2O3 "CN(C)c1ccc(cc1)c2ccc(cc2)CN(c3cccc(c3)C=CC(=O)OC)C(=O)C4CCCCC4

" Ambient "Fang S, Suh JM, Reilly SM, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65. PMID: 25559344.

 

Downes M, Verdecia MA, Roecker AJ, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92. PMID: 12718892.

" Not dangerous goods.

LKT A2532 AGI-6780 5 mg 106.8 Isocitrate dehydrogenase inhibitor. 1432660-47-3 ≥98% 481.51 C21H18F3N3O3S2 Ambient "Lee WY, Chen KC, Chen HY, et al. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. Biomed Res Int. 2014;2014:364625. PMID: 24995286.

 

Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6. PMID: 23558173.

" Not dangerous goods.

LKT A2532 AGI-6780 25 mg 426.9 Isocitrate dehydrogenase inhibitor. 1432660-47-3 ≥98% 481.51 C21H18F3N3O3S2 Ambient "Lee WY, Chen KC, Chen HY, et al. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. Biomed Res Int. 2014;2014:364625. PMID: 24995286.

 

Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6. PMID: 23558173.

" Not dangerous goods.

LKT S1609 Securinine 10 mg 105 Alkaloid found in Securinega; potential GABA-A antagonist. Securinan-11-one 5610-40-2 ≥98% 217.26 C13H15NO2 C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4 Ambient -20°C Soluble in ethanol 16 mg/mL, DMSO 50 mg/mL.  Insoluble in water. "Han S, Zhang G, Li M, et al. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway. Oncol Rep. 2014 May;31(5):2245-51. PMID: 24676995.

 

Li M, Han S, Zhang G, et al. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Pharmazie. 2014 Mar;69(3):217-23. PMID: 24716413.

 

Shipman M, Lubick K, Fouchard D, et al. Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant. PLoS One. 2012;7(9):e41278. PMID: 23028424.

 

Singh AK, Pandey MB, Singh S, et al. Antifungal Activity of Securinine against Some Plant Pathogenic Fungi. Mycobiology. 2008 Jun;36(2):99-101. PMID: 23990741.

 

Lin X, Jun-Tian Z. Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35). Neurol Res. 2004 Oct;26(7):792-6. PMID: 15494124.

 

Rana S, Gupta K, Gomez J, et al. Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. FASEB. 2010 Jun;24(6):2126-2134. PMID: 20133503.

" Xn Not dangerous goods.

LKT S1609 Securinine 25 mg 236.3 Alkaloid found in Securinega; potential GABA-A antagonist. Securinan-11-one 5610-40-2 ≥98% 217.26 C13H15NO2 C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4 Ambient -20°C Soluble in ethanol 16 mg/mL, DMSO 50 mg/mL.  Insoluble in water. "Han S, Zhang G, Li M, et al. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway. Oncol Rep. 2014 May;31(5):2245-51. PMID: 24676995.

 

Li M, Han S, Zhang G, et al. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Pharmazie. 2014 Mar;69(3):217-23. PMID: 24716413.

 

Shipman M, Lubick K, Fouchard D, et al. Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant. PLoS One. 2012;7(9):e41278. PMID: 23028424.

 

Singh AK, Pandey MB, Singh S, et al. Antifungal Activity of Securinine against Some Plant Pathogenic Fungi. Mycobiology. 2008 Jun;36(2):99-101. PMID: 23990741.

 

Lin X, Jun-Tian Z. Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35). Neurol Res. 2004 Oct;26(7):792-6. PMID: 15494124.

 

Rana S, Gupta K, Gomez J, et al. Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. FASEB. 2010 Jun;24(6):2126-2134. PMID: 20133503.

" Xn Not dangerous goods.

LKT I7468 Isradipine 5 mg 42 Calcium channel blocker. 75695-93-1 ≥98% 371.39 "CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)c2cccc3c2non3)C(=O)OC

" Ambient Ambient "Lee HA, Hyun SA, Park SG, et al. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization. Korean J Physiol Pharmacol. 2016 Jan; 20(1):119-127. PMID: 26807031.

 

Anekonda TS, Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: the case for isradipine. Biochim Biophys Acta. 2011 Dec; 1812(12): 1584-1590. PMID: 21925266.

 

Ilijic E, Guzman JN, Surmeier DJ. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis. 2011 Aug; 43(2): 364-371. PMID: 21515375.

" Not dangerous goods.

LKT I7468 Isradipine 25 mg 152.3 Calcium channel blocker. 75695-93-1 ≥98% 371.39 "CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)c2cccc3c2non3)C(=O)OC

" Ambient Ambient "Lee HA, Hyun SA, Park SG, et al. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization. Korean J Physiol Pharmacol. 2016 Jan; 20(1):119-127. PMID: 26807031.

 

Anekonda TS, Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: the case for isradipine. Biochim Biophys Acta. 2011 Dec; 1812(12): 1584-1590. PMID: 21925266.

 

Ilijic E, Guzman JN, Surmeier DJ. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis. 2011 Aug; 43(2): 364-371. PMID: 21515375.

" Not dangerous goods.

LKT I7468 Isradipine 50 mg 283.5 Calcium channel blocker. 75695-93-1 ≥98% 371.39 "CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)c2cccc3c2non3)C(=O)OC

" Ambient Ambient "Lee HA, Hyun SA, Park SG, et al. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization. Korean J Physiol Pharmacol. 2016 Jan; 20(1):119-127. PMID: 26807031.

 

Anekonda TS, Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: the case for isradipine. Biochim Biophys Acta. 2011 Dec; 1812(12): 1584-1590. PMID: 21925266.

 

Ilijic E, Guzman JN, Surmeier DJ. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis. 2011 Aug; 43(2): 364-371. PMID: 21515375.

" Not dangerous goods.

LKT N3474 Nisoldipine 10 mg 47.3 Calcium channel blocker. 63675-72-9 ≥98% 388.42 "CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)c2ccccc2[N+](=O)[O-])C(=O)OC

" Ambient 4°C "Missan S, Zhabyeyev P, Dyachok O, et al. Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov; 140(5): 863-870. PMID: 14530219.

 

Stasch J, Kazda S, Hirth C, et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension. 1987 Sep; 10(3): 303-307. PMID: 2957322.

 

Pan Y, Li L, Kim G, et al. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening. Drug Metab Dispos. 2011 Feb; 39(2): 337-344. PMID: 21068194.

" Not dangerous goods.

LKT N3474 Nisoldipine 50 mg 105 Calcium channel blocker. 63675-72-9 ≥98% 388.42 "CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)c2ccccc2[N+](=O)[O-])C(=O)OC

" Ambient 4°C "Missan S, Zhabyeyev P, Dyachok O, et al. Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov; 140(5): 863-870. PMID: 14530219.

 

Stasch J, Kazda S, Hirth C, et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension. 1987 Sep; 10(3): 303-307. PMID: 2957322.

 

Pan Y, Li L, Kim G, et al. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening. Drug Metab Dispos. 2011 Feb; 39(2): 337-344. PMID: 21068194.

" Not dangerous goods.

LKT L0108 Lacidipine 10 mg 63 Calcium channel blocker. 103890-78-4 ≥98% 455.55 "CCOC(=O)C1=C(NC(=C(C1c2ccccc2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C

" Ambient 4°C "Ge Y, Li G, Liu B, et al. The Protective Effect of Lacidipine on myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evid Based Complement Alternat Med. 2015; 2015: 945076. PMID: 25688281.

 

Wang F, Chou A, Segatori L. Lacidipine Remodels Protein Folding and Ca2+ Homeostasis in Gaucher’s Disease Fibroblasts: A Mechanism to Rescue Mutant Glucocerebrosidase. Chem Biol. 2011 Jun 24; 18(6):766-76. PMID: 21700212.

 

Wang F, Segatori L. Remodeling the Proteostasis Network to Rescue Glucocerebrosidase Variants by Inhibiting ER-Associated Degradation and Enhancing ER Folding. PLoS One. 2013 Apr 19; 8(4):e61418. PMID: 23620750.

 

Dasgupta A, Dastidar S,  Antibacterial & antitoxic effects of the cardiovascular drug lacidipine in an animal model. Indian J Med Res. 2012 Jun; 135(6): 913-916. PMID: 22825612.

 

" Not dangerous goods.

LKT L0108 Lacidipine 50 mg 189 Calcium channel blocker. 103890-78-4 ≥98% 455.55 "CCOC(=O)C1=C(NC(=C(C1c2ccccc2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C

" Ambient 4°C "Ge Y, Li G, Liu B, et al. The Protective Effect of Lacidipine on myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evid Based Complement Alternat Med. 2015; 2015: 945076. PMID: 25688281.

 

Wang F, Chou A, Segatori L. Lacidipine Remodels Protein Folding and Ca2+ Homeostasis in Gaucher’s Disease Fibroblasts: A Mechanism to Rescue Mutant Glucocerebrosidase. Chem Biol. 2011 Jun 24; 18(6):766-76. PMID: 21700212.

 

Wang F, Segatori L. Remodeling the Proteostasis Network to Rescue Glucocerebrosidase Variants by Inhibiting ER-Associated Degradation and Enhancing ER Folding. PLoS One. 2013 Apr 19; 8(4):e61418. PMID: 23620750.

 

Dasgupta A, Dastidar S,  Antibacterial & antitoxic effects of the cardiovascular drug lacidipine in an animal model. Indian J Med Res. 2012 Jun; 135(6): 913-916. PMID: 22825612.

 

" Not dangerous goods.

LKT E2258 Efonidipine Hydrochloride 10 mg 99.8 Calcium channel blocker. NZ-105 111011-53-1 ≥98% "CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)c3cccc(c3)[N+](=O)[O-])C(=O)OCCN(Cc4ccccc4)c5ccccc5.Cl

" Ambient 4°C "Furukawa T.,Miura R,Honda M, et al. Idenfication of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels.  Br. J Pharmacol.  2004 Dec; 143(8):1050-7.  PIMD:15545287, PMCID:PMC1575949.

 

Tanaka H, Shigenobu K.  Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels.  Cardiovascv Drug Rev.  2002 Winter; 20(1):81-92.  PMID:12070536.

 

Imafawa K, Okayama S, Takaoka M, et al Inhibitory effect of efonidipine on aldosterone synthesis and secretion on human adrenocarcinoma (H195R) cells. J Cardiovasc Pharmacol. 2006 Jan; 47(1):133-8.  PMID:16424797.

 

Ikeda K, Saito T, Tojo K.  Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H195 R human adrenocortical carcinoma cells.  Tohoku J Exp Med.  2011; 224(4):263-71.  PMID:21757861." Not dangerous goods.

LKT E2258 Efonidipine Hydrochloride 50 mg 341.3 Calcium channel blocker. NZ-105 111011-53-1 ≥98% "CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)c3cccc(c3)[N+](=O)[O-])C(=O)OCCN(Cc4ccccc4)c5ccccc5.Cl

" Ambient 4°C "Furukawa T.,Miura R,Honda M, et al. Idenfication of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels.  Br. J Pharmacol.  2004 Dec; 143(8):1050-7.  PIMD:15545287, PMCID:PMC1575949.

 

Tanaka H, Shigenobu K.  Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels.  Cardiovascv Drug Rev.  2002 Winter; 20(1):81-92.  PMID:12070536.

 

Imafawa K, Okayama S, Takaoka M, et al Inhibitory effect of efonidipine on aldosterone synthesis and secretion on human adrenocarcinoma (H195R) cells. J Cardiovasc Pharmacol. 2006 Jan; 47(1):133-8.  PMID:16424797.

 

Ikeda K, Saito T, Tojo K.  Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H195 R human adrenocortical carcinoma cells.  Tohoku J Exp Med.  2011; 224(4):263-71.  PMID:21757861." Not dangerous goods.

LKT B1752 Benidipine Hydrochloride 10 mg 36.8 Calcium channel blocker. KW-3049 91599-74-5 ≥98% 542.03 "CC1=C(C(C(=C(N1)C)C(=O)OC2CCCN(C2)Cc3ccccc3)c4cccc(c4)[N+](=O)[O-])C(=O)OC.Cl

" Ambient Ambient "Matsubara M , Yao K, Hasegawa K.  Benidipine, a dihydropyridine-calcium channel blocker, inhibits

lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.Pharmacol Res. 2006 Jan;53(1):35-43.  PMID: 16172001.

 

Wang N , Minatoguchi S, Chen XH, et al.

Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits.  J Cardiovasc Pharmacol. 2004 Jun;43(6):747-57.  PMID: 15167267.

 

Ide S , Kondoh M, Satoh H, Karasawa A.  Anti-proliferative effects of benidipine hydrochloride in porcine cultured

vascular smooth muscle cells and in rats subjected to balloon catheterinduced endothelial denudation.Biol Pharm Bull. 1994 May;17(5):627-31.  PMID: 7920421." "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Benidipine hydrochloride)"

LKT B1752 Benidipine Hydrochloride 25 mg 68.3 Calcium channel blocker. KW-3049 91599-74-5 ≥98% 542.03 "CC1=C(C(C(=C(N1)C)C(=O)OC2CCCN(C2)Cc3ccccc3)c4cccc(c4)[N+](=O)[O-])C(=O)OC.Cl

" Ambient Ambient "Matsubara M , Yao K, Hasegawa K.  Benidipine, a dihydropyridine-calcium channel blocker, inhibits

lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.Pharmacol Res. 2006 Jan;53(1):35-43.  PMID: 16172001.

 

Wang N , Minatoguchi S, Chen XH, et al.

Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits.  J Cardiovasc Pharmacol. 2004 Jun;43(6):747-57.  PMID: 15167267.

 

Ide S , Kondoh M, Satoh H, Karasawa A.  Anti-proliferative effects of benidipine hydrochloride in porcine cultured

vascular smooth muscle cells and in rats subjected to balloon catheterinduced endothelial denudation.Biol Pharm Bull. 1994 May;17(5):627-31.  PMID: 7920421." "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Benidipine hydrochloride)"

LKT B1752 Benidipine Hydrochloride 100 mg 152.3 Calcium channel blocker. KW-3049 91599-74-5 ≥98% 542.03 "CC1=C(C(C(=C(N1)C)C(=O)OC2CCCN(C2)Cc3ccccc3)c4cccc(c4)[N+](=O)[O-])C(=O)OC.Cl

" Ambient Ambient "Matsubara M , Yao K, Hasegawa K.  Benidipine, a dihydropyridine-calcium channel blocker, inhibits

lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.Pharmacol Res. 2006 Jan;53(1):35-43.  PMID: 16172001.

 

Wang N , Minatoguchi S, Chen XH, et al.

Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits.  J Cardiovasc Pharmacol. 2004 Jun;43(6):747-57.  PMID: 15167267.

 

Ide S , Kondoh M, Satoh H, Karasawa A.  Anti-proliferative effects of benidipine hydrochloride in porcine cultured

vascular smooth muscle cells and in rats subjected to balloon catheterinduced endothelial denudation.Biol Pharm Bull. 1994 May;17(5):627-31.  PMID: 7920421." "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Benidipine hydrochloride)"

LKT L1869 Lercanidipine Hydrochloride 10 mg 102.9 Calcium channel blocker. 132866-11-6 ≥98% 648.2 "CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c3ccccc3)c4cccc(c4)[N+](=O)[O-])C(=O)OC.Cl

" Ambient 4°C "Sabbatini M1, Leonardi A, Testa R, et al. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.  J Cardiovasc Pharmacol. 2002 Jan;39(1):39-48.  PMID: 11743226.

 

Sabbatini M1, Tomassoni D, Di Tullio MA, Amenta F.  Neuroprotective effect of treatment with calcium antagonists on hypertensive retina.  Clin Exp Hypertens. 2002 Oct-Nov;24(7-8):727-40.  PMID: 12450247.

 

Martinez ML1, Lopes LF, Coelho EB, et al.  Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension.  J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22.  PMID: 16424795.

 

Bastos MF1, Vasconcelos de Araújo I, et al.  Effects of lercanidipine on bone density and bone repair in spontaneously hypertensive rats.  Implant Dent. 2013 Feb;22(1):49-54. doi: 10.1097/ID.0b013e3182777650.  PMID: 23287976." "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Lercanidipine hydrochloride)"

LKT L1869 Lercanidipine Hydrochloride 50 mg 404.3 Calcium channel blocker. 132866-11-6 ≥98% 648.2 "CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c3ccccc3)c4cccc(c4)[N+](=O)[O-])C(=O)OC.Cl

" Ambient 4°C "Sabbatini M1, Leonardi A, Testa R, et al. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.  J Cardiovasc Pharmacol. 2002 Jan;39(1):39-48.  PMID: 11743226.

 

Sabbatini M1, Tomassoni D, Di Tullio MA, Amenta F.  Neuroprotective effect of treatment with calcium antagonists on hypertensive retina.  Clin Exp Hypertens. 2002 Oct-Nov;24(7-8):727-40.  PMID: 12450247.

 

Martinez ML1, Lopes LF, Coelho EB, et al.  Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension.  J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22.  PMID: 16424795.

 

Bastos MF1, Vasconcelos de Araújo I, et al.  Effects of lercanidipine on bone density and bone repair in spontaneously hypertensive rats.  Implant Dent. 2013 Feb;22(1):49-54. doi: 10.1097/ID.0b013e3182777650.  PMID: 23287976." "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Lercanidipine hydrochloride)"

LKT A9617 Azelnidipine 10 mg 78.8 Dihydropyridine; L-type Ca2+ channel blocker. 123524-52-7 ≥98% 582.66 "CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(c3ccccc3)c4ccccc4)c5cccc(c5)[N+](=O)[O-])C(=O)OC(C)C

" Ambient -20°C "Tawaramoto K, Kaneto H, Hashiramoto M, et al. Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study). Diabetol Metab Syndr. 2015 Sep 17;7:80. PMID: 26388951.

 

Tatsumi F, Kaneto H, Hashiramoto M, et al. Anti-hypertensive azelnidipine preserves insulin signaling and glucose uptake against oxidative stress in 3T3-L1 adipocytes. Endocr J. 2015;62(8):741-7. PMID: 26073866.

 

Chen BL, Zhang YZ, Luo JQ, et al. Clinical use of azelnidipine in the treatment of hypertension in Chinese patients. Ther Clin Risk Manag. 2015 Feb 24;11:309-18. PMID: 25750535.

" Not dangerous goods.

LKT A9617 Azelnidipine 50 mg 341.3 Dihydropyridine; L-type Ca2+ channel blocker. 123524-52-7 ≥98% 582.66 "CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(c3ccccc3)c4ccccc4)c5cccc(c5)[N+](=O)[O-])C(=O)OC(C)C

" Ambient -20°C "Tawaramoto K, Kaneto H, Hashiramoto M, et al. Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study). Diabetol Metab Syndr. 2015 Sep 17;7:80. PMID: 26388951.

 

Tatsumi F, Kaneto H, Hashiramoto M, et al. Anti-hypertensive azelnidipine preserves insulin signaling and glucose uptake against oxidative stress in 3T3-L1 adipocytes. Endocr J. 2015;62(8):741-7. PMID: 26073866.

 

Chen BL, Zhang YZ, Luo JQ, et al. Clinical use of azelnidipine in the treatment of hypertension in Chinese patients. Ther Clin Risk Manag. 2015 Feb 24;11:309-18. PMID: 25750535.

" Not dangerous goods.

LKT T6817 D(+)-Trehalose Dihydrate 1 g 29.4 α-Linked disaccharide composed of α-glucose units; potential TLR modulator. 6138-23-4 ≥98% 378.33 "C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O

" Ambient Ambient "Williams B, Njaci I, Moghaddam L, et al. Trehalose Accumulation Triggers Autophagy during Plant Desiccation. PLoS Genet. 2015 Dec 3;11(12):e1005705. PMID: 26633550.

 

Jiang YL, Li SX, Liu YJ, et al. Synthesis and Evaluation of Trehalose-Based Compounds as Novel Inhibitors of Cancer Cell Migration and Invasion. Chem Biol Drug Des. 2015 Nov;86(5):1017-29. PMID: 25855371.

 

Rodriguez Lavado J, Sestito SE, Cighetti R, et al. Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem. 2014 Nov 13;57(21):9105-23. PMID: 25268544.

" Not dangerous goods.

LKT T6817 D(+)-Trehalose Dihydrate 5 g 78.8 α-Linked disaccharide composed of α-glucose units; potential TLR modulator. 6138-23-4 ≥98% 378.33 "C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O

" Ambient Ambient "Williams B, Njaci I, Moghaddam L, et al. Trehalose Accumulation Triggers Autophagy during Plant Desiccation. PLoS Genet. 2015 Dec 3;11(12):e1005705. PMID: 26633550.

 

Jiang YL, Li SX, Liu YJ, et al. Synthesis and Evaluation of Trehalose-Based Compounds as Novel Inhibitors of Cancer Cell Migration and Invasion. Chem Biol Drug Des. 2015 Nov;86(5):1017-29. PMID: 25855371.

 

Rodriguez Lavado J, Sestito SE, Cighetti R, et al. Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem. 2014 Nov 13;57(21):9105-23. PMID: 25268544.

" Not dangerous goods.

LKT T6817 D(+)-Trehalose Dihydrate 25 g 168 α-Linked disaccharide composed of α-glucose units; potential TLR modulator. 6138-23-4 ≥98% 378.33 "C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O

" Ambient Ambient "Williams B, Njaci I, Moghaddam L, et al. Trehalose Accumulation Triggers Autophagy during Plant Desiccation. PLoS Genet. 2015 Dec 3;11(12):e1005705. PMID: 26633550.

 

Jiang YL, Li SX, Liu YJ, et al. Synthesis and Evaluation of Trehalose-Based Compounds as Novel Inhibitors of Cancer Cell Migration and Invasion. Chem Biol Drug Des. 2015 Nov;86(5):1017-29. PMID: 25855371.

 

Rodriguez Lavado J, Sestito SE, Cighetti R, et al. Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem. 2014 Nov 13;57(21):9105-23. PMID: 25268544.

" Not dangerous goods.

LKT L3326 Ligustrazine Hydrochloride 1 g 47.3 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine Hydrochloride 76494-51-4 ≥98% 172.66 "Cc1c(nc(c(n1)C)C)C.Cl

" Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT L3326 Ligustrazine Hydrochloride 5 g 131.3 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine Hydrochloride 76494-51-4 ≥98% 172.66 "Cc1c(nc(c(n1)C)C)C.Cl

" Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT L3326 Ligustrazine Hydrochloride 25 g 341.3 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine Hydrochloride 76494-51-4 ≥98% 172.66 "Cc1c(nc(c(n1)C)C)C.Cl

" Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT T1778 2,3,5,6-Tetramethylpyrazine 25 g 47.3 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine; Ligustrazine 1124-11-4 ≥98% 136.2 Cc1c(nc(c(n1)C)C)C Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT T1778 2,3,5,6-Tetramethylpyrazine 100 g 126 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine; Ligustrazine 1124-11-4 ≥98% 136.2 Cc1c(nc(c(n1)C)C)C Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT T1778 2,3,5,6-Tetramethylpyrazine 500 g 367.5 Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist. Tetramethylpyrazine; Ligustrazine 1124-11-4 ≥98% 136.2 Cc1c(nc(c(n1)C)C)C Ambient Ambient "Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

 

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

 

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

 

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

 

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

 

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

 

Zhao S, Zhang Y, Chen Q, et al. A modified ""double-hit"" induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

 

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

" Not dangerous goods.

LKT T0142 TAK-733 5 mg 194.3 MEK inhibitor. 3-[(2R)-2,3-Dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione TAK733 1035555-63-5 ≥98% 504.23 "Cn1c2c(c(c(c1=O)F)Nc3ccc(cc3F)I)c(=O)n(cn2)CC(CO)O

" Ambient -20°C "Lieu CH, Klauck PJ, Henthorn PK, et al. Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts. Oncotarget. 2015 Oct 27;6(33):34561-72. PMID: 26439693.

 

Ishino S, Miyake H, Vincent P, et al. Evaluation of the therapeutic efficacy of a MEK inhibitor (TAK-733) using ¹⁸F-fluorodeoxyglucose-positron emission tomography in the human lung xenograft model A549. Ann Nucl Med. 2015 Aug;29(7):613-20. PMID: 26014721.

 

Micel LN, Tentler JJ, Tan AC, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25. PMID: 25376610.

 

von Euw E, Atefi M, Attar N, et al. Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines. Mol Cancer. 2012 Apr 19;11:22. PMID: 22515704.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s (TAK733)"

LKT T0142 TAK-733 10 mg 346.5 MEK inhibitor. 3-[(2R)-2,3-Dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione TAK733 1035555-63-5 ≥98% 504.23 "Cn1c2c(c(c(c1=O)F)Nc3ccc(cc3F)I)c(=O)n(cn2)CC(CO)O

" Ambient -20°C "Lieu CH, Klauck PJ, Henthorn PK, et al. Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts. Oncotarget. 2015 Oct 27;6(33):34561-72. PMID: 26439693.

 

Ishino S, Miyake H, Vincent P, et al. Evaluation of the therapeutic efficacy of a MEK inhibitor (TAK-733) using ¹⁸F-fluorodeoxyglucose-positron emission tomography in the human lung xenograft model A549. Ann Nucl Med. 2015 Aug;29(7):613-20. PMID: 26014721.

 

Micel LN, Tentler JJ, Tan AC, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25. PMID: 25376610.

 

von Euw E, Atefi M, Attar N, et al. Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines. Mol Cancer. 2012 Apr 19;11:22. PMID: 22515704.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s (TAK733)"

LKT N4974 NMS-E628 1 mg 183.8 ALK and Ros1 inhibitor, Trk antagonist. Entrectinib, RXDX-101 1108743-60-7 ≥98% 560.64 "CN1CCN(CC1)c2ccc(c(c2)NC3CCOCC3)C(=O)Nc4c5cc(ccc5[nH]n4)Cc6cc(cc(c6)F)F

" Ambient 4°C "Amatu A, Somaschini A, Cerea G, et al. Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. Br J Cancer. 2015 Dec 3. [Epub ahead of print]. PMID: 26633560.

 

Farago AF, Le LP, Zheng Z, et al. Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2015 Nov 12. [Epub ahead of print]. PMID: 26565381.

 

Rolfo C, Ruiz R, Giovannetti E, et al. Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. Expert Opin Investig Drugs. 2015 Nov;24(11):1493-500. PMID: 26457764.

" Not dangerous goods.

LKT N4974 NMS-E628 5 mg 577.5 ALK and Ros1 inhibitor, Trk antagonist. Entrectinib, RXDX-101 1108743-60-7 ≥98% 560.64 "CN1CCN(CC1)c2ccc(c(c2)NC3CCOCC3)C(=O)Nc4c5cc(ccc5[nH]n4)Cc6cc(cc(c6)F)F

" Ambient 4°C "Amatu A, Somaschini A, Cerea G, et al. Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. Br J Cancer. 2015 Dec 3. [Epub ahead of print]. PMID: 26633560.

 

Farago AF, Le LP, Zheng Z, et al. Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2015 Nov 12. [Epub ahead of print]. PMID: 26565381.

 

Rolfo C, Ruiz R, Giovannetti E, et al. Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. Expert Opin Investig Drugs. 2015 Nov;24(11):1493-500. PMID: 26457764.

" Not dangerous goods.

LKT N4974 NMS-E628 10 mg 1029 ALK and Ros1 inhibitor, Trk antagonist. Entrectinib, RXDX-101 1108743-60-7 ≥98% 560.64 "CN1CCN(CC1)c2ccc(c(c2)NC3CCOCC3)C(=O)Nc4c5cc(ccc5[nH]n4)Cc6cc(cc(c6)F)F

" Ambient 4°C "Amatu A, Somaschini A, Cerea G, et al. Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. Br J Cancer. 2015 Dec 3. [Epub ahead of print]. PMID: 26633560.

 

Farago AF, Le LP, Zheng Z, et al. Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2015 Nov 12. [Epub ahead of print]. PMID: 26565381.

 

Rolfo C, Ruiz R, Giovannetti E, et al. Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. Expert Opin Investig Drugs. 2015 Nov;24(11):1493-500. PMID: 26457764.

" Not dangerous goods.

LKT L9704 LY-2603618 5 mg 183.8 Chk1 inhibitor. Rabusertib 911222-45-2 ≥98% 436.31 "Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OCC3CNCCO3

" Ambient -20°C "Barnard D, Diaz HB, Burke T, et al. LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models. Invest New Drugs. 2015 Nov 27. [Epub ahead of print]. PMID: 26612134.

 

Wang FZ, Fei HR, Cui YJ, et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis. 2014 Sep;19(9):1389-98. PMID: 24928205.

 

King C, Diaz H, Barnard D, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. PMID: 24114124.

" Not dangerous goods.

LKT L9704 LY-2603618 10 mg 341.3 Chk1 inhibitor. Rabusertib 911222-45-2 ≥98% 436.31 "Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OCC3CNCCO3

" Ambient -20°C "Barnard D, Diaz HB, Burke T, et al. LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models. Invest New Drugs. 2015 Nov 27. [Epub ahead of print]. PMID: 26612134.

 

Wang FZ, Fei HR, Cui YJ, et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis. 2014 Sep;19(9):1389-98. PMID: 24928205.

 

King C, Diaz H, Barnard D, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. PMID: 24114124.

" Not dangerous goods.

LKT L9704 LY-2603618 25 mg 656.3 Chk1 inhibitor. Rabusertib 911222-45-2 ≥98% 436.31 "Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OCC3CNCCO3

" Ambient -20°C "Barnard D, Diaz HB, Burke T, et al. LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models. Invest New Drugs. 2015 Nov 27. [Epub ahead of print]. PMID: 26612134.

 

Wang FZ, Fei HR, Cui YJ, et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis. 2014 Sep;19(9):1389-98. PMID: 24928205.

 

King C, Diaz H, Barnard D, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. PMID: 24114124.

" Not dangerous goods.

LKT C1176 CCT-128930 5 mg 157.5 Pyrrolopyrimidine; Akt inhibitor. CCT128930 885499-61-6 ≥96% 341.84 Ambient -20°C "Wang FZ, Chang ZY, Fei HR, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014 Aug;103:118-25. PMID: 24793486.

 

Yap TA, Walton MI, Hunter LJ, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71. PMID: 21191045.

 

Caldwell JJ, Davies TG, Donald A, et al. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem. 2008 Apr 10;51(7):2147-57. PMID: 18345609.

" Not dangerous goods.

LKT C1176 CCT-128930 10 mg 288.8 Pyrrolopyrimidine; Akt inhibitor. CCT128930 885499-61-6 ≥96% 341.84 Ambient -20°C "Wang FZ, Chang ZY, Fei HR, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014 Aug;103:118-25. PMID: 24793486.

 

Yap TA, Walton MI, Hunter LJ, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71. PMID: 21191045.

 

Caldwell JJ, Davies TG, Donald A, et al. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem. 2008 Apr 10;51(7):2147-57. PMID: 18345609.

" Not dangerous goods.

LKT C1176 CCT-128930 25 mg 572.3 Pyrrolopyrimidine; Akt inhibitor. CCT128930 885499-61-6 ≥96% 341.84 Ambient -20°C "Wang FZ, Chang ZY, Fei HR, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014 Aug;103:118-25. PMID: 24793486.

 

Yap TA, Walton MI, Hunter LJ, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71. PMID: 21191045.

 

Caldwell JJ, Davies TG, Donald A, et al. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem. 2008 Apr 10;51(7):2147-57. PMID: 18345609.

" Not dangerous goods.

LKT A9813 AZD-8931 5 mg 194.3 Inhibitor of EGFR, HER2, and HER3. AZD8931, Sapitinib 848942-61-0 ≥98% 473.93 "CNC(=O)CN1CCC(CC1)Oc2cc3c(cc2OC)ncnc3Nc4cccc(c4F)Cl

" Ambient -20°C "Mu Z, Klinowska T, Dong X, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30;33:47. PMID: 24886365.

 

Tjulandin S, Moiseyenko V, Semiglazov V, et al. Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):145-53. PMID: 23589215.

 

Hickinson DM, Klinowska T, Speake G, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69. PMID: 20145185.

" Not dangerous goods.

LKT A9813 AZD-8931 10 mg 341.3 Inhibitor of EGFR, HER2, and HER3. AZD8931, Sapitinib 848942-61-0 ≥98% 473.93 "CNC(=O)CN1CCC(CC1)Oc2cc3c(cc2OC)ncnc3Nc4cccc(c4F)Cl

" Ambient -20°C "Mu Z, Klinowska T, Dong X, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30;33:47. PMID: 24886365.

 

Tjulandin S, Moiseyenko V, Semiglazov V, et al. Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):145-53. PMID: 23589215.

 

Hickinson DM, Klinowska T, Speake G, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69. PMID: 20145185.

" Not dangerous goods.

LKT A9813 AZD-8931 25 mg 682.5 Inhibitor of EGFR, HER2, and HER3. AZD8931, Sapitinib 848942-61-0 ≥98% 473.93 "CNC(=O)CN1CCC(CC1)Oc2cc3c(cc2OC)ncnc3Nc4cccc(c4F)Cl

" Ambient -20°C "Mu Z, Klinowska T, Dong X, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30;33:47. PMID: 24886365.

 

Tjulandin S, Moiseyenko V, Semiglazov V, et al. Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):145-53. PMID: 23589215.

 

Hickinson DM, Klinowska T, Speake G, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69. PMID: 20145185.

" Not dangerous goods.

LKT A9713 AZD-3514 5 mg 262.5 Androgen receptor downregulator. AZD3514 1240299-33-5 ≥98% 519.57 Ambient -20°C "Omlin A, Jones RJ, van der Noll R, et al. AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies. Invest New Drugs. 2015 Jun;33(3):679-90. PMID: 25920479.

 

Loddick SA, Ross SJ, Thomason AG, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. PMID: 23861347.

 

Bradbury RH, Acton DG, Broadbent NL, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. PMID: 23466225.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (AZD3514)"

LKT A9713 AZD-3514 25 mg 787.5 Androgen receptor downregulator. AZD3514 1240299-33-5 ≥98% 519.57 Ambient -20°C "Omlin A, Jones RJ, van der Noll R, et al. AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies. Invest New Drugs. 2015 Jun;33(3):679-90. PMID: 25920479.

 

Loddick SA, Ross SJ, Thomason AG, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. PMID: 23861347.

 

Bradbury RH, Acton DG, Broadbent NL, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. PMID: 23466225.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (AZD3514)"

LKT A1616 AEE-788 5 mg 99.8 Inhibitor of EGFR, HER2, VEGFR2, and FLT3. AEE788, NVP-AEE788 497839-62-0 ≥98% 440.6 "CCN1CCN(CC1)Cc2ccc(cc2)c3cc4c([nH]3)ncnc4NC(C)c5ccccc5

" Ambient -20°C "Baselga J, Mita AC, Schöffski P, et al. Using pharmacokinetic and pharmacodynamic data in early decision making regarding drug development: a phase I clinical trial evaluating tyrosine kinase inhibitor, AEE788. Clin Cancer Res. 2012 Nov 15;18(22):6364-72. PMID: 23014528.

 

Servidei T, Meco D, Trivieri N, et al. Effects of epidermal growth factor receptor blockade on ependymoma stem cells in vitro and in orthotopic mouse models. Int J Cancer. 2012 Sep 1;131(5):E791-803. PMID: 22120695.

 

Reardon DA, Conrad CA, Cloughesy T, et al. Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients. Cancer Chemother Pharmacol. 2012 Jun;69(6):1507-18. PMID: 22392572.

 

Barbarroja N, Torres LA, Rodriguez-Ariza A, et al. AEE788 is a vascular endothelial growth factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute myeloid leukemia. Exp Hematol. 2010 Aug;38(8):641-52. PMID: 20380868.

" Not dangerous goods.

LKT A1616 AEE-788 25 mg 383.3 Inhibitor of EGFR, HER2, VEGFR2, and FLT3. AEE788, NVP-AEE788 497839-62-0 ≥98% 440.6 "CCN1CCN(CC1)Cc2ccc(cc2)c3cc4c([nH]3)ncnc4NC(C)c5ccccc5

" Ambient -20°C "Baselga J, Mita AC, Schöffski P, et al. Using pharmacokinetic and pharmacodynamic data in early decision making regarding drug development: a phase I clinical trial evaluating tyrosine kinase inhibitor, AEE788. Clin Cancer Res. 2012 Nov 15;18(22):6364-72. PMID: 23014528.

 

Servidei T, Meco D, Trivieri N, et al. Effects of epidermal growth factor receptor blockade on ependymoma stem cells in vitro and in orthotopic mouse models. Int J Cancer. 2012 Sep 1;131(5):E791-803. PMID: 22120695.

 

Reardon DA, Conrad CA, Cloughesy T, et al. Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients. Cancer Chemother Pharmacol. 2012 Jun;69(6):1507-18. PMID: 22392572.

 

Barbarroja N, Torres LA, Rodriguez-Ariza A, et al. AEE788 is a vascular endothelial growth factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute myeloid leukemia. Exp Hematol. 2010 Aug;38(8):641-52. PMID: 20380868.

" Not dangerous goods.

LKT T5869 Torcetrapib 5 mg 99.8 Cholesterol ester transfer protein inhibitor. ≥98% 600.48 "Briand F, Prunet-Marcassus B, Thieblemont Q, et al. Raising HDL with CETP inhibitor torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters. Atherosclerosis. 2014 Apr;233(2):359-62. PMID: 24530763.

 

Fan S, Geng Q, Pan Z, et al. Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152. PMID: 23228038.

 

Johns DG, Duffy J, Fisher T, et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors. Drugs. 2012 Mar 5;72(4):491-507. PMID: 22356288.

 

" Not dangerous goods.

LKT T5869 Torcetrapib 10 mg 131.3 Cholesterol ester transfer protein inhibitor. ≥98% 600.48 "Briand F, Prunet-Marcassus B, Thieblemont Q, et al. Raising HDL with CETP inhibitor torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters. Atherosclerosis. 2014 Apr;233(2):359-62. PMID: 24530763.

 

Fan S, Geng Q, Pan Z, et al. Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152. PMID: 23228038.

 

Johns DG, Duffy J, Fisher T, et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors. Drugs. 2012 Mar 5;72(4):491-507. PMID: 22356288.

 

" Not dangerous goods.

LKT T5869 Torcetrapib 25 mg 262.5 Cholesterol ester transfer protein inhibitor. ≥98% 600.48 "Briand F, Prunet-Marcassus B, Thieblemont Q, et al. Raising HDL with CETP inhibitor torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters. Atherosclerosis. 2014 Apr;233(2):359-62. PMID: 24530763.

 

Fan S, Geng Q, Pan Z, et al. Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152. PMID: 23228038.

 

Johns DG, Duffy J, Fisher T, et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors. Drugs. 2012 Mar 5;72(4):491-507. PMID: 22356288.

 

" Not dangerous goods.

LKT E8401 Evacetrapib 5 mg 183.8 Cholesterol ester transfer protein inhibitor. LY2484595 ≥98% 638.66 "Nicholls SJ, Ruotolo G, Brewer HB, et al. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17;66(20):2201-10. PMID: 26564598.

 

Suico JG, Wang MD, Friedrich S, et al. Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults. J Pharm Pharmacol. 2014 Nov;66(11):1576-85. PMID: 24961753.

 

Cao G, Beyer TP, Zhang Y, et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011 Dec;52(12):2169-76. PMID: 21957197.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Evacetrapib)"

LKT E8401 Evacetrapib 10 mg 315 Cholesterol ester transfer protein inhibitor. LY2484595 ≥98% 638.66 "Nicholls SJ, Ruotolo G, Brewer HB, et al. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17;66(20):2201-10. PMID: 26564598.

 

Suico JG, Wang MD, Friedrich S, et al. Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults. J Pharm Pharmacol. 2014 Nov;66(11):1576-85. PMID: 24961753.

 

Cao G, Beyer TP, Zhang Y, et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011 Dec;52(12):2169-76. PMID: 21957197.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Evacetrapib)"

LKT E8401 Evacetrapib 25 mg 609 Cholesterol ester transfer protein inhibitor. LY2484595 ≥98% 638.66 "Nicholls SJ, Ruotolo G, Brewer HB, et al. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17;66(20):2201-10. PMID: 26564598.

 

Suico JG, Wang MD, Friedrich S, et al. Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults. J Pharm Pharmacol. 2014 Nov;66(11):1576-85. PMID: 24961753.

 

Cao G, Beyer TP, Zhang Y, et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011 Dec;52(12):2169-76. PMID: 21957197.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Evacetrapib)"

LKT D0244 Dalcetrapib 5 mg 194.3 Cholesterol ester transfer protein inhibitor. JTT-705, RO4607381 ≥98% 389.6 "Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Nov 29;367(22):2089-99. PMID: 23126252.

 

Goldberg AS, Hegele RA. Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib. Drug Des Devel Ther. 2012;6:251-9. PMID: 23055695.

 

Robinson JG. Dalcetrapib: a review of Phase II data. Expert Opin Investig Drugs. 2010 Jun;19(6):795-805. PMID: 20465364.

" Not dangerous goods.

LKT D0244 Dalcetrapib 10 mg 351.8 Cholesterol ester transfer protein inhibitor. JTT-705, RO4607381 ≥98% 389.6 "Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Nov 29;367(22):2089-99. PMID: 23126252.

 

Goldberg AS, Hegele RA. Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib. Drug Des Devel Ther. 2012;6:251-9. PMID: 23055695.

 

Robinson JG. Dalcetrapib: a review of Phase II data. Expert Opin Investig Drugs. 2010 Jun;19(6):795-805. PMID: 20465364.

" Not dangerous goods.

LKT D0244 Dalcetrapib 25 mg 682.5 Cholesterol ester transfer protein inhibitor. JTT-705, RO4607381 ≥98% 389.6 "Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Nov 29;367(22):2089-99. PMID: 23126252.

 

Goldberg AS, Hegele RA. Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib. Drug Des Devel Ther. 2012;6:251-9. PMID: 23055695.

 

Robinson JG. Dalcetrapib: a review of Phase II data. Expert Opin Investig Drugs. 2010 Jun;19(6):795-805. PMID: 20465364.

" Not dangerous goods.

LKT A5301 "Anacetrapib

" 5 mg 183.8 Cholesterol ester transfer protein inhibitor. MK-0859 ≥98% 637.52 "van der Tuin SJ, Kühnast S, Berbée JF, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res. 2015 Nov;56(11):2085-93. PMID: 26342106.

 

Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015 Jun;125(6):2510-22. PMID: 25961461.

 

Äijänen T, Koivuniemi A, Javanainen M, et al. How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. PLoS Comput Biol. 2014 Nov 20;10(11):e1003987. PMID: 25412509.

 

Hooper AJ, Burnett JR. Anacetrapib, a cholesteryl ester transfer protein inhibitor. Expert Opin Investig Drugs. 2012 Jan;21(1):103-9. PMID: 22191425.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Anacetrapib)"

LKT A5301 "Anacetrapib

" 10 mg 336 Cholesterol ester transfer protein inhibitor. MK-0859 ≥98% 637.52 "van der Tuin SJ, Kühnast S, Berbée JF, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res. 2015 Nov;56(11):2085-93. PMID: 26342106.

 

Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015 Jun;125(6):2510-22. PMID: 25961461.

 

Äijänen T, Koivuniemi A, Javanainen M, et al. How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. PLoS Comput Biol. 2014 Nov 20;10(11):e1003987. PMID: 25412509.

 

Hooper AJ, Burnett JR. Anacetrapib, a cholesteryl ester transfer protein inhibitor. Expert Opin Investig Drugs. 2012 Jan;21(1):103-9. PMID: 22191425.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Anacetrapib)"

LKT A5301 "Anacetrapib

" 25 mg 630 Cholesterol ester transfer protein inhibitor. MK-0859 ≥98% 637.52 "van der Tuin SJ, Kühnast S, Berbée JF, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res. 2015 Nov;56(11):2085-93. PMID: 26342106.

 

Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015 Jun;125(6):2510-22. PMID: 25961461.

 

Äijänen T, Koivuniemi A, Javanainen M, et al. How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. PLoS Comput Biol. 2014 Nov 20;10(11):e1003987. PMID: 25412509.

 

Hooper AJ, Burnett JR. Anacetrapib, a cholesteryl ester transfer protein inhibitor. Expert Opin Investig Drugs. 2012 Jan;21(1):103-9. PMID: 22191425.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Anacetrapib)"

LKT Z8401 Z-VAD-FMK 1 mg 314.6 Non-specific caspase inhibitor used to prevent apoptosis. Z-VAD(OMe)-FMK; pan-Caspase Inhibitor; Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone; Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone 187389-52-2 ≥95% 467.49 Ambient 4°C Soluble in DMSO, acetonitrile or dimethyl formamide. "Burmistrova O, Perdomo J, Simões MF, et al. The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells. Phytomedicine. 2015 Oct 15;22(11):1009-16. PMID: 26407943.

 

Choi EY, Shin KC, Lee J, et al. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pac J Cancer Prev. 2015;16(14):5883-7. PMID: 26320467.

 

Davis DA, Naiman NE, Wang V, et al. Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses. PLoS Pathog. 2015 Jul 28;11(7):e1005064. PMID: 26218605.

" Not dangerous goods.

LKT Z8401 Z-VAD-FMK 5 mg 1038.1 Non-specific caspase inhibitor used to prevent apoptosis. Z-VAD(OMe)-FMK; pan-Caspase Inhibitor; Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone; Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone 187389-52-2 ≥95% 467.49 Ambient 4°C Soluble in DMSO, acetonitrile or dimethyl formamide. "Burmistrova O, Perdomo J, Simões MF, et al. The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells. Phytomedicine. 2015 Oct 15;22(11):1009-16. PMID: 26407943.

 

Choi EY, Shin KC, Lee J, et al. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pac J Cancer Prev. 2015;16(14):5883-7. PMID: 26320467.

 

Davis DA, Naiman NE, Wang V, et al. Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses. PLoS Pathog. 2015 Jul 28;11(7):e1005064. PMID: 26218605.

" Not dangerous goods.

LKT Y0800 YC-1 1 mg 31.5 Guanylyl cyclase activator and HIF-1α inhibitor. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole 170632-47-0 ≥98% 304.35 Ambient 4°C Soluble in DMSO, methanol or dichloromethane. "Brownfoot FC, Tong S, Hannan NJ, et al. YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. Mol Cell Endocrinol. 2015 Sep 15;413:202-8. PMID: 26159901.

 

Xiao J, Jin C, Liu Z, et al. The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents. Org Biomol Chem. 2015 Jul 14;13(26):7257-64. PMID: 26055070.

 

Kambayashi S, Igase M, Kobayashi K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015 Jun 6. [Epub ahead of print]. PMID: 26050843.

 

Tsou CY, Chen CY, Zhao JF, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. PMID: 24299003.

 

Purohit R, Fritz BG, The J, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. PMID: 24328155.

 

Tsai YC, Lee YM, Lam KK, et al. The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells. PLoS One. 2013 Jul 26;8(7):e69320. PMID: 23922702.

" Not dangerous goods.

LKT Y0800 YC-1 5 mg 102.3 Guanylyl cyclase activator and HIF-1α inhibitor. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole 170632-47-0 ≥98% 304.35 Ambient 4°C Soluble in DMSO, methanol or dichloromethane. "Brownfoot FC, Tong S, Hannan NJ, et al. YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. Mol Cell Endocrinol. 2015 Sep 15;413:202-8. PMID: 26159901.

 

Xiao J, Jin C, Liu Z, et al. The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents. Org Biomol Chem. 2015 Jul 14;13(26):7257-64. PMID: 26055070.

 

Kambayashi S, Igase M, Kobayashi K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015 Jun 6. [Epub ahead of print]. PMID: 26050843.

 

Tsou CY, Chen CY, Zhao JF, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. PMID: 24299003.

 

Purohit R, Fritz BG, The J, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. PMID: 24328155.

 

Tsai YC, Lee YM, Lam KK, et al. The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells. PLoS One. 2013 Jul 26;8(7):e69320. PMID: 23922702.

" Not dangerous goods.

LKT Y0800 YC-1 25 mg 409 Guanylyl cyclase activator and HIF-1α inhibitor. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole 170632-47-0 ≥98% 304.35 Ambient 4°C Soluble in DMSO, methanol or dichloromethane. "Brownfoot FC, Tong S, Hannan NJ, et al. YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. Mol Cell Endocrinol. 2015 Sep 15;413:202-8. PMID: 26159901.

 

Xiao J, Jin C, Liu Z, et al. The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents. Org Biomol Chem. 2015 Jul 14;13(26):7257-64. PMID: 26055070.

 

Kambayashi S, Igase M, Kobayashi K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015 Jun 6. [Epub ahead of print]. PMID: 26050843.

 

Tsou CY, Chen CY, Zhao JF, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. PMID: 24299003.

 

Purohit R, Fritz BG, The J, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. PMID: 24328155.

 

Tsai YC, Lee YM, Lam KK, et al. The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells. PLoS One. 2013 Jul 26;8(7):e69320. PMID: 23922702.

" Not dangerous goods.

LKT T1878 Tetrodotoxin Citrate 1 mg 228.1 Neurotoxin found in puffer fish; site 1 voltage-gated Na+ channel blocker. TTX 18660-81-6 ≥99% 319.27 "C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O

" Ambient 4°C Soluble in water. "Matson DJ, Hamamoto DT, Bregman H, et al. Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. PLoS One. 2015 Sep 17;10(9):e0138140. PMID: 26379236.

 

Eberhardt E, Havlicek S, Schmidt D, et al. Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors. Stem Cell Reports. 2015 Sep 8;5(3):305-13. PMID: 26321143.

 

Puilingi CG, Kudo Y, Cho Y, et al. Tetrodotoxin and Its Analogues in the Pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A Comparison of Their Toxin Profiles with the Same Species from Okinawa, Japan. Toxins (Basel). 2015 Aug 26;7(9):3436-54. PMID: 26343722.

 

Hagen NA, Lapointe B, Ong-Lam M, et al. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Curr Oncol. 2011 Jun;18(3):e109-16. PMID: 21655148.

" "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Tetrodotoxin citrate)"

LKT S3470 Sirtinol 1 mg 55 Sirtuin inhibitor and iron chelator. 410536-97-9 ≥98% 394.47 Ambient 4°C Soluble in DMSO, 100% ethanol or dimethyl formamide. "Kanda T, Sasaki R, Nakamoto S, et al. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. Biochem Biophys Res Commun. 2015 Oct 23;466(3):567-71. PMID: 26388050.

 

Lee M, Kim DW, Yoon H, et al. Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 2015 Sep 2. [Epub ahead of print]. PMID: 26342525.

 

Zhang L, Ma R, Hu J, et al. Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis. PLoS One. 2015 Jul 15;10(7):e0132941. PMID: 26176547.

 

Gautam R, Akam EA, Astashkin AV, et al. Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chem Commun (Camb). 2015 Mar 25;51(24):5104-7. PMID: 25715179.

 

Tsai YF, Yu HP, Chang WY, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. PMID: 25666548.

 

Botti C, Caiafa I, Coppola A, et al. SIRT1 inhibition affects angiogenic properties of human MSCs. Biomed Res Int. 2014;2014:783459. PMID: 25243179.

 

Fong Y, Lin YC, Wu CY, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. PMID: 25184156.

 

Back JH, Rezvani HR, Zhu Y, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. J Biol Chem. 2011 May 27;286(21):19100-19108. PMID: 21471201.

" Not dangerous goods.

LKT S3470 Sirtinol 5 mg 165.2 Sirtuin inhibitor and iron chelator. 410536-97-9 ≥98% 394.47 Ambient 4°C Soluble in DMSO, 100% ethanol or dimethyl formamide. "Kanda T, Sasaki R, Nakamoto S, et al. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. Biochem Biophys Res Commun. 2015 Oct 23;466(3):567-71. PMID: 26388050.

 

Lee M, Kim DW, Yoon H, et al. Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 2015 Sep 2. [Epub ahead of print]. PMID: 26342525.

 

Zhang L, Ma R, Hu J, et al. Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis. PLoS One. 2015 Jul 15;10(7):e0132941. PMID: 26176547.

 

Gautam R, Akam EA, Astashkin AV, et al. Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chem Commun (Camb). 2015 Mar 25;51(24):5104-7. PMID: 25715179.

 

Tsai YF, Yu HP, Chang WY, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. PMID: 25666548.

 

Botti C, Caiafa I, Coppola A, et al. SIRT1 inhibition affects angiogenic properties of human MSCs. Biomed Res Int. 2014;2014:783459. PMID: 25243179.

 

Fong Y, Lin YC, Wu CY, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. PMID: 25184156.

 

Back JH, Rezvani HR, Zhu Y, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. J Biol Chem. 2011 May 27;286(21):19100-19108. PMID: 21471201.

" Not dangerous goods.

LKT S3470 Sirtinol 25 mg 534.8 Sirtuin inhibitor and iron chelator. 410536-97-9 ≥98% 394.47 Ambient 4°C Soluble in DMSO, 100% ethanol or dimethyl formamide. "Kanda T, Sasaki R, Nakamoto S, et al. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. Biochem Biophys Res Commun. 2015 Oct 23;466(3):567-71. PMID: 26388050.

 

Lee M, Kim DW, Yoon H, et al. Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition. J Allergy Clin Immunol. 2015 Sep 2. [Epub ahead of print]. PMID: 26342525.

 

Zhang L, Ma R, Hu J, et al. Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis. PLoS One. 2015 Jul 15;10(7):e0132941. PMID: 26176547.

 

Gautam R, Akam EA, Astashkin AV, et al. Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chem Commun (Camb). 2015 Mar 25;51(24):5104-7. PMID: 25715179.

 

Tsai YF, Yu HP, Chang WY, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. PMID: 25666548.

 

Botti C, Caiafa I, Coppola A, et al. SIRT1 inhibition affects angiogenic properties of human MSCs. Biomed Res Int. 2014;2014:783459. PMID: 25243179.

 

Fong Y, Lin YC, Wu CY, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. PMID: 25184156.

 

Back JH, Rezvani HR, Zhu Y, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1. J Biol Chem. 2011 May 27;286(21):19100-19108. PMID: 21471201.

" Not dangerous goods.

LKT S0225 SAG Dihydrochloride 1 mg 149.4 Smoothened agonist. ≥98% 617.02 Ambient 4°C Soluble in water or DMSO. "Huang JG, Shen CB, Wu WB, et al. Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro. J Neurosci Res. 2014 May;92(5):587-96. PMID: 24464877.

 

Heine VM, Griveau A, Chapin C, et al. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19;3(105):105ra104. PMID: 22013124.

 

Bidet M, Joubert O, Lacombe B, et al. The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834. PMID: 21931618.

 

Wang G, Zhang Z, Xu Z, et al. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta. 2010 Dec;1803(12):1359-67. PMID: 20840857.

" Not dangerous goods.

LKT S0225 SAG Dihydrochloride 5 mg 597.7 Smoothened agonist. ≥98% 617.02 Ambient 4°C Soluble in water or DMSO. "Huang JG, Shen CB, Wu WB, et al. Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro. J Neurosci Res. 2014 May;92(5):587-96. PMID: 24464877.

 

Heine VM, Griveau A, Chapin C, et al. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19;3(105):105ra104. PMID: 22013124.

 

Bidet M, Joubert O, Lacombe B, et al. The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834. PMID: 21931618.

 

Wang G, Zhang Z, Xu Z, et al. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta. 2010 Dec;1803(12):1359-67. PMID: 20840857.

" Not dangerous goods.

LKT S0224 SAG 1 mg 188.8 Smoothened agonist. 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide 912545-86-9 ≥98% 490.06 Ambient 4°C Soluble in DMSO. Sparingly soluble in water (acidification with HCl increases water solubility). "Huang JG, Shen CB, Wu WB, et al. Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro. J Neurosci Res. 2014 May;92(5):587-96. PMID: 24464877.

 

Heine VM, Griveau A, Chapin C, et al. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19;3(105):105ra104. PMID: 22013124.

 

Bidet M, Joubert O, Lacombe B, et al. The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834. PMID: 21931618.

 

Wang G, Zhang Z, Xu Z, et al. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta. 2010 Dec;1803(12):1359-67. PMID: 20840857.

" Not dangerous goods.

LKT S0224 SAG 5 mg 755 Smoothened agonist. 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide 912545-86-9 ≥98% 490.06 Ambient 4°C Soluble in DMSO. Sparingly soluble in water (acidification with HCl increases water solubility). "Huang JG, Shen CB, Wu WB, et al. Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro. J Neurosci Res. 2014 May;92(5):587-96. PMID: 24464877.

 

Heine VM, Griveau A, Chapin C, et al. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19;3(105):105ra104. PMID: 22013124.

 

Bidet M, Joubert O, Lacombe B, et al. The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834. PMID: 21931618.

 

Wang G, Zhang Z, Xu Z, et al. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta. 2010 Dec;1803(12):1359-67. PMID: 20840857.

" Not dangerous goods.

LKT K5200 KN-93 1 mg 133.7 CamKII inhibitor and potential L-type Ca2+ channel blocker. 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine 1188890-41-6 ≥98% 599.03 Ambient 4°C Soluble in water "Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. PMID: 26024774.

 

Tzimas C, Terrovitis J, Lehnart SE, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm. 2015 Jul;12(7):1599-610. PMID: 25814413.

 

Daft PG, Yang Y, Napierala D, et al. The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism. PLoS One. 2015 Apr 10;10(4):e0121568. PMID: 25860662.

 

Bian H, Yu LC. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neurosci Lett. 2014 Nov 7;583:6-10. PMID: 25218714.

 

Koga T, Mi M, Yoshida N, et al. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. PMID: 24829059.

" Not dangerous goods.

LKT K5200 KN-93 5 mg 456.1 CamKII inhibitor and potential L-type Ca2+ channel blocker. 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine 1188890-41-6 ≥98% 599.03 Ambient 4°C Soluble in water "Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. PMID: 26024774.

 

Tzimas C, Terrovitis J, Lehnart SE, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm. 2015 Jul;12(7):1599-610. PMID: 25814413.

 

Daft PG, Yang Y, Napierala D, et al. The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism. PLoS One. 2015 Apr 10;10(4):e0121568. PMID: 25860662.

 

Bian H, Yu LC. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neurosci Lett. 2014 Nov 7;583:6-10. PMID: 25218714.

 

Koga T, Mi M, Yoshida N, et al. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. PMID: 24829059.

" Not dangerous goods.

LKT K5200 KN-93 25 mg 1140.4 CamKII inhibitor and potential L-type Ca2+ channel blocker. 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine 1188890-41-6 ≥98% 599.03 Ambient 4°C Soluble in water "Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. PMID: 26024774.

 

Tzimas C, Terrovitis J, Lehnart SE, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm. 2015 Jul;12(7):1599-610. PMID: 25814413.

 

Daft PG, Yang Y, Napierala D, et al. The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism. PLoS One. 2015 Apr 10;10(4):e0121568. PMID: 25860662.

 

Bian H, Yu LC. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neurosci Lett. 2014 Nov 7;583:6-10. PMID: 25218714.

 

Koga T, Mi M, Yoshida N, et al. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. PMID: 24829059.

" Not dangerous goods.

LKT J0800 JC-1 1 mg 86.5 "Potential-dependent J-aggregate-forming cation, detects changes in the mitochondrial membrane potential.

" 3520-43-2 ≥90% 652.23 "CCn1c2cc(c(cc2[n+](c1C=CC=C3N(c4cc(c(cc4N3CC)Cl)Cl)CC)CC)Cl)Cl.[IH-]

" Ambient 4°C Soluble in methanol, DMSO. "Zhang C, Tian Y, Song F, et al. Salinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells. Oncol Rep. 2015 Sep 8. [Epub ahead of print]. PMID: 26352531.

 

Jiang Z, Li X, Lin Z, et al. Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7774-85. PMID: 26339342.

 

Smiley ST, Reers M, Mottola-Hartshorn C, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3671-5. PMID: 2023917.

" Not dangerous goods.

LKT J0800 JC-1 5 mg 235.9 "Potential-dependent J-aggregate-forming cation, detects changes in the mitochondrial membrane potential.

" 3520-43-2 ≥90% 652.23 "CCn1c2cc(c(cc2[n+](c1C=CC=C3N(c4cc(c(cc4N3CC)Cl)Cl)CC)CC)Cl)Cl.[IH-]

" Ambient 4°C Soluble in methanol, DMSO. "Zhang C, Tian Y, Song F, et al. Salinomycin inhibits the growth of colorectal carcinoma by targeting tumor stem cells. Oncol Rep. 2015 Sep 8. [Epub ahead of print]. PMID: 26352531.

 

Jiang Z, Li X, Lin Z, et al. Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7774-85. PMID: 26339342.

 

Smiley ST, Reers M, Mottola-Hartshorn C, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3671-5. PMID: 2023917.

" Not dangerous goods.

LKT J0274 Jasplakinolide 50 µg 298.8 Marine toxin; actin polymerization inducer. 102396-24-7 ≥98% 709.68 Ambient 4°C Soluble in ethanol, methanol or DMSO. "Aida N, Ushikubo T, Kobayashi F, et al. Actin stabilization induces apoptosis in cultured porcine epithelial cell rests of Malassez. Int Endod J. 2015 Jun 27. [Epub ahead of print]. PMID: 26118334.

 

Cheng Y, Feng Y, Jansson L, et al. Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. 2015 Jun;29(6):2423-30. PMID: 25690654.

 

Schwingshackl A, Roan E, Teng B, et al. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. PLoS One. 2015 May 22;10(5):e0126781. PMID: 26001192.

" Not dangerous goods.

LKT J0274 Jasplakinolide 100 µg 550.5 Marine toxin; actin polymerization inducer. 102396-24-7 ≥98% 709.68 Ambient 4°C Soluble in ethanol, methanol or DMSO. "Aida N, Ushikubo T, Kobayashi F, et al. Actin stabilization induces apoptosis in cultured porcine epithelial cell rests of Malassez. Int Endod J. 2015 Jun 27. [Epub ahead of print]. PMID: 26118334.

 

Cheng Y, Feng Y, Jansson L, et al. Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. 2015 Jun;29(6):2423-30. PMID: 25690654.

 

Schwingshackl A, Roan E, Teng B, et al. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. PLoS One. 2015 May 22;10(5):e0126781. PMID: 26001192.

" Not dangerous goods.

LKT F8250 Fumitremorgin C 250 µg 267.4 Mycotoxin found in Aspergillus and Penicillum; ABC-G2 inhibitor. 118974-02-0 ≥98% 379.46 Ambient 4°C Soluble in DMSO, methanol, acetone, DMF or chloroform. "Dame ZT, Suwannarach N, Lumyong S, et al. A new citrinin dimer isolated from Aspergillus terreus strain ZDF21. Nat Prod Commun. 2015 Apr;10(4):623-4. PMID: 25973492.

 

Xie J, Jin B, Li DW, et al. ABCG2 regulated by MAPK pathways is associated with cancer progression in laryngeal squamous cell carcinoma. Am J Cancer Res. 2014 Nov 19;4(6):698-709. PMID: 25520861.

 

Liu HB, Meng QH, Du DW, et al. The effects of ABCG2 on the viability, proliferation and paracrine actions of kidney side population cells under oxygen-glucose deprivation. Int J Med Sci. 2014 Jul 20;11(10):1001-8. PMID: 25076846.

" Not dangerous goods.

LKT F8250 Fumitremorgin C 1 mg 723.6 Mycotoxin found in Aspergillus and Penicillum; ABC-G2 inhibitor. 118974-02-0 ≥98% 379.46 Ambient 4°C Soluble in DMSO, methanol, acetone, DMF or chloroform. "Dame ZT, Suwannarach N, Lumyong S, et al. A new citrinin dimer isolated from Aspergillus terreus strain ZDF21. Nat Prod Commun. 2015 Apr;10(4):623-4. PMID: 25973492.

 

Xie J, Jin B, Li DW, et al. ABCG2 regulated by MAPK pathways is associated with cancer progression in laryngeal squamous cell carcinoma. Am J Cancer Res. 2014 Nov 19;4(6):698-709. PMID: 25520861.

 

Liu HB, Meng QH, Du DW, et al. The effects of ABCG2 on the viability, proliferation and paracrine actions of kidney side population cells under oxygen-glucose deprivation. Int J Med Sci. 2014 Jul 20;11(10):1001-8. PMID: 25076846.

" Not dangerous goods.

LKT F7444 FSL-1 100 µg 298.8 Adjuvant; TLR2/6 agonist. Fibroblast-stimulating Lipopeptide; Pam2CGDPKHPKSF; (R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH 322455-70-9 ≥98% 1666.2 Ambient 4°C Soluble in water (10mg/ml). Use a homogeniser or sonicator to prepare a homogenous solution. "Tunis MC, Dawod B, Carson KR, et al. Toll-like receptor 2 activators modulate oral tolerance in mice. Clin Exp Allergy. 2015 Aug 4. [Epub ahead of print]. PMID: 26242919.

 

Lim R, Barker G, Lappas M. The TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88/TRAF6/NF-κB-dependent signalling. Am J Reprod Immunol. 2014 May;71(5):401-17. PMID: 24635133.

 

Buffa V, Klein K, Fischetti L, et al. Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. PLoS One. 2012;7(12):e50529. PMID: 23272062.

 

Kiura K, Hasebe A, Saeki A, et al. In vivo anti- and pro-tumour activities of the TLR2 ligand FSL-1. Immunobiology. 2011 Aug;216(8):891-900. PMID: 21496943.

" Not dangerous goods.

LKT E8260 Eupatilin 5 mg 125.8 O-methylated flavone found in Artemisia; PPARα activator. 22368-21-4 ≥98% 344.32 "COc1ccc(cc1OC)c2cc(=O)c3c(o2)cc(c(c3O)OC)O

" Ambient 4°C Soluble in DMSO, hot methanol or mixture of methanol and chloroform. "Choi Y, Jung Y, Kim SN. Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS. Molecules. 2015 Jul 28;20(8):13753-63. PMID: 26225954.

 

Jeong JH, Moon SJ, Jhun JY, et al. Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes. PLoS One. 2015 Jun 17;10(6):e0130882. PMID: 26083352.

 

Jeong HJ, Kim JH, Kim NR, et al. Antidepressant effect of Stillen. Arch Pharm Res. 2015 Jun;38(6):1223-31. PMID: 25163682.

 

Jeong EK, Jang HJ, Kim SS, et al. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplant Proc. 2015 Apr;47(3):757-62. PMID: 25891726.

 

Ryoo SB, Oh HK, Yu SA, et al. The effects of eupatilin (stillen®) on motility of human lower gastrointestinal tracts. Korean J Physiol Pharmacol. 2014 Oct;18(5):383-90. PMID: 25352757.

 

Park BB, Yoon Js, Kim Es, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumour Biol. 2013 Apr;34(2):875-85. PMID: 23292941.

 

Lim JC, Park SY, Nam Y, et al. The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells. Korean J Physiol Pharmacol. 2012 Oct;16(5):313-20. PMID: 23118554.

 

Cai M, Phan PT, Hong JG, et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. Eur J Pharmacol. 2012 Aug 15;689(1-3):104-10. PMID: 22683875.

 

Cheong JH, Hong SY, Zheng Y, et al. Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression. J Gastric Cancer. 2011 Mar;11(1):16-22. PMID: 22076197.

" Not dangerous goods.

LKT E8260 Eupatilin 25 mg 503.4 O-methylated flavone found in Artemisia; PPARα activator. 22368-21-4 ≥98% 344.32 "COc1ccc(cc1OC)c2cc(=O)c3c(o2)cc(c(c3O)OC)O

" Ambient 4°C Soluble in DMSO, hot methanol or mixture of methanol and chloroform. "Choi Y, Jung Y, Kim SN. Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS. Molecules. 2015 Jul 28;20(8):13753-63. PMID: 26225954.

 

Jeong JH, Moon SJ, Jhun JY, et al. Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes. PLoS One. 2015 Jun 17;10(6):e0130882. PMID: 26083352.

 

Jeong HJ, Kim JH, Kim NR, et al. Antidepressant effect of Stillen. Arch Pharm Res. 2015 Jun;38(6):1223-31. PMID: 25163682.

 

Jeong EK, Jang HJ, Kim SS, et al. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplant Proc. 2015 Apr;47(3):757-62. PMID: 25891726.

 

Ryoo SB, Oh HK, Yu SA, et al. The effects of eupatilin (stillen®) on motility of human lower gastrointestinal tracts. Korean J Physiol Pharmacol. 2014 Oct;18(5):383-90. PMID: 25352757.

 

Park BB, Yoon Js, Kim Es, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumour Biol. 2013 Apr;34(2):875-85. PMID: 23292941.

 

Lim JC, Park SY, Nam Y, et al. The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells. Korean J Physiol Pharmacol. 2012 Oct;16(5):313-20. PMID: 23118554.

 

Cai M, Phan PT, Hong JG, et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. Eur J Pharmacol. 2012 Aug 15;689(1-3):104-10. PMID: 22683875.

 

Cheong JH, Hong SY, Zheng Y, et al. Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression. J Gastric Cancer. 2011 Mar;11(1):16-22. PMID: 22076197.

" Not dangerous goods.

LKT G0250 cGAMP Disodium [STING Ligand] 100 µg 141.5 Cyclic dinucleotide that detects cytosolic DNA and induces STING-dependent interferon type 1 responses. cyclic (adenosine monophosphate-guanosine monophosphate); cyclic GMP-AMP; c-(GpAp); 3',3'-cGAMP ≥98% 718.37 Ambient 4°C Soluble in water. "Ma F, Li B, Liu SY, et al. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015 Feb 15;194(4):1545-54. PMID: 25609843.

 

Škrnjug I, Guzmán CA, Rueckert C. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. Erratum in: PLoS One. 2015;10(3):e0123605. Ruecker, Christine [corrected to Rueckert, Christine].  PMID: 25295996.

 

Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. PMID: 23258412.

" Not dangerous goods.

LKT G0250 cGAMP Disodium [STING Ligand] 500 µg 409 Cyclic dinucleotide that detects cytosolic DNA and induces STING-dependent interferon type 1 responses. cyclic (adenosine monophosphate-guanosine monophosphate); cyclic GMP-AMP; c-(GpAp); 3',3'-cGAMP ≥98% 718.37 Ambient 4°C Soluble in water. "Ma F, Li B, Liu SY, et al. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015 Feb 15;194(4):1545-54. PMID: 25609843.

 

Škrnjug I, Guzmán CA, Rueckert C. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. Erratum in: PLoS One. 2015;10(3):e0123605. Ruecker, Christine [corrected to Rueckert, Christine].  PMID: 25295996.

 

Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. PMID: 23258412.

" Not dangerous goods.

LKT B4796 BLZ-945 1 mg 70.8 CSF-1R Inhibitor. BLZ945 953769-46-5 ≥95% 398.48 "CNC(=O)c1cc(ccn1)Oc2ccc3c(c2)sc(n3)NC4CCCCC4O

" Ambient 4°C Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. "Krauser JA, Jin Y, Walles M, et al. Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica. 2015 Feb;45(2):107-23. PMID: 25180976.

 

Strachan DC, Ruffell B, Oei Y, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968. PMID: 24498562.

" Not dangerous goods.

LKT B4796 BLZ-945 5 mg 212.3 CSF-1R Inhibitor. BLZ945 953769-46-5 ≥95% 398.48 "CNC(=O)c1cc(ccn1)Oc2ccc3c(c2)sc(n3)NC4CCCCC4O

" Ambient 4°C Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. "Krauser JA, Jin Y, Walles M, et al. Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica. 2015 Feb;45(2):107-23. PMID: 25180976.

 

Strachan DC, Ruffell B, Oei Y, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968. PMID: 24498562.

" Not dangerous goods.

LKT B4796 BLZ-945 25 mg 644.9 CSF-1R Inhibitor. BLZ945 953769-46-5 ≥95% 398.48 "CNC(=O)c1cc(ccn1)Oc2ccc3c(c2)sc(n3)NC4CCCCC4O

" Ambient 4°C Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. "Krauser JA, Jin Y, Walles M, et al. Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica. 2015 Feb;45(2):107-23. PMID: 25180976.

 

Strachan DC, Ruffell B, Oei Y, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968. PMID: 24498562.

" Not dangerous goods.

LKT A7476 Astaxanthin 5 mg 78.6 Carotenoid found in shrimp, salmon, and algae. 3,3'-Dihydroxy-β-carotene-4,4'-dione; all-trans-Astaxanthin; Ovoester; NSC635689; CCRIS 7118; HSDB 7468 472-61-7 ≥97% 596.85 "CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C

" Ambient 4°C Soluble in DMSO, chloroform or DMF. Soluble in ethanol or methanol if heated. Insoluble in water "Wen X, Huang A, Hu J, et al. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway. Neuroscience. 2015 Sep 10;303:558-68. PMID: 26197224.

 

Zhou X, Zhang F, Hu X, et al. Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice. Physiol Behav. 2015 Aug 10;151:412-420. PMID: 26272354.

 

Chen YY, Lee PC, Wu YL, et al. In Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet. PLoS One. 2015 Aug 11;10(8):e0134733. PMID: 26262684.

 

Xu L, Zhu J, Yin W, et al. Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6083-94. PMID: 26261486.

" Not dangerous goods.

LKT A7476 Astaxanthin 25 mg 235.9 Carotenoid found in shrimp, salmon, and algae. 3,3'-Dihydroxy-β-carotene-4,4'-dione; all-trans-Astaxanthin; Ovoester; NSC635689; CCRIS 7118; HSDB 7468 472-61-7 ≥97% 596.85 "CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C

" Ambient 4°C Soluble in DMSO, chloroform or DMF. Soluble in ethanol or methanol if heated. Insoluble in water "Wen X, Huang A, Hu J, et al. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway. Neuroscience. 2015 Sep 10;303:558-68. PMID: 26197224.

 

Zhou X, Zhang F, Hu X, et al. Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice. Physiol Behav. 2015 Aug 10;151:412-420. PMID: 26272354.

 

Chen YY, Lee PC, Wu YL, et al. In Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet. PLoS One. 2015 Aug 11;10(8):e0134733. PMID: 26262684.

 

Xu L, Zhu J, Yin W, et al. Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6083-94. PMID: 26261486.

" Not dangerous goods.

LKT G0244 alpha-Galactosylceramide 250 µg 149.4 Synthetic glycolipid found in Agelas mauritanius; binds CD1d. alpha-Gal-Cer, KRN7000 158021-47-7 ≥96% 858.34 "CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O

" Blue Ice 4°C Soluble in pyridine. Solubilization in Tween20 or PBS for cell culture use see online protocol. "Zhang F, Zhu Z, Meadows GG, et al. Chronic alcohol consumption inhibits melanoma growth but decreases the survival of mice immunized with tumor cell lysate and boosted with α-galactosylceramide. Int Immunopharmacol. 2015 Sep;28(1):359-68. PMID: 26118634.

 

Macho-Fernandez E, Brigl M. The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol. 2015 Jul 28;6:362. PMID: 26284062.

 

Franck RW. C-Galactosylceramide: Synthesis and Immunology. C R Chim. 2012 Jan 1;15(1):46-56. PMID: 22408579.

" Not dangerous goods.

LKT G0244 alpha-Galactosylceramide 1 mg 361.7 Synthetic glycolipid found in Agelas mauritanius; binds CD1d. alpha-Gal-Cer, KRN7000 158021-47-7 ≥96% 858.34 "CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O

" Blue Ice 4°C Soluble in pyridine. Solubilization in Tween20 or PBS for cell culture use see online protocol. "Zhang F, Zhu Z, Meadows GG, et al. Chronic alcohol consumption inhibits melanoma growth but decreases the survival of mice immunized with tumor cell lysate and boosted with α-galactosylceramide. Int Immunopharmacol. 2015 Sep;28(1):359-68. PMID: 26118634.

 

Macho-Fernandez E, Brigl M. The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol. 2015 Jul 28;6:362. PMID: 26284062.

 

Franck RW. C-Galactosylceramide: Synthesis and Immunology. C R Chim. 2012 Jan 1;15(1):46-56. PMID: 22408579.

" Not dangerous goods.

LKT A3208 AICAR 10 mg 31.5 AMPK activator. 5-aminoimidazole-4 -carboxamide-1-β-D-ribofuranoside 2627-69-2 ≥98% 258.23 "c1nc(c(n1C2C(C(C(O2)CO)O)O)N)C(=O)N

" Ambient 4°C Soluble in water (9 mg/ml), DMSO or dimethyl formamid "Mukhopadhyay S, Chatterjee A, Kogan D, et al. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015 Aug 31:0. [Epub ahead of print]. PMID: 26323019.

 

Greig FH, Ewart MA, McNaughton E, et al. The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascul Pharmacol. 2015 Jul 18. [Epub ahead of print]. PMID: 26196300.

 

Niederberger E, King TS, Russe OQ, et al. Activation of AMPK and its Impact on Exercise Capacity. Sports Med. 2015 Jul 18. [Epub ahead of print]. PMID: 26186961.

 

Radika MK, Anuradha CV. Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues. J Basic Clin Physiol Pharmacol. 2015 Jun 27. [Epub ahead of print]. PMID: 26124049.

" Not dangerous goods.

LKT A3208 AICAR 50 mg 110.1 AMPK activator. 5-aminoimidazole-4 -carboxamide-1-β-D-ribofuranoside 2627-69-2 ≥98% 258.23 "c1nc(c(n1C2C(C(C(O2)CO)O)O)N)C(=O)N

" Ambient 4°C Soluble in water (9 mg/ml), DMSO or dimethyl formamid "Mukhopadhyay S, Chatterjee A, Kogan D, et al. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015 Aug 31:0. [Epub ahead of print]. PMID: 26323019.

 

Greig FH, Ewart MA, McNaughton E, et al. The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascul Pharmacol. 2015 Jul 18. [Epub ahead of print]. PMID: 26196300.

 

Niederberger E, King TS, Russe OQ, et al. Activation of AMPK and its Impact on Exercise Capacity. Sports Med. 2015 Jul 18. [Epub ahead of print]. PMID: 26186961.

 

Radika MK, Anuradha CV. Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues. J Basic Clin Physiol Pharmacol. 2015 Jun 27. [Epub ahead of print]. PMID: 26124049.

" Not dangerous goods.

LKT A3208 AICAR 100 mg 188.8 AMPK activator. 5-aminoimidazole-4 -carboxamide-1-β-D-ribofuranoside 2627-69-2 ≥98% 258.23 "c1nc(c(n1C2C(C(C(O2)CO)O)O)N)C(=O)N

" Ambient 4°C Soluble in water (9 mg/ml), DMSO or dimethyl formamid "Mukhopadhyay S, Chatterjee A, Kogan D, et al. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015 Aug 31:0. [Epub ahead of print]. PMID: 26323019.

 

Greig FH, Ewart MA, McNaughton E, et al. The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascul Pharmacol. 2015 Jul 18. [Epub ahead of print]. PMID: 26196300.

 

Niederberger E, King TS, Russe OQ, et al. Activation of AMPK and its Impact on Exercise Capacity. Sports Med. 2015 Jul 18. [Epub ahead of print]. PMID: 26186961.

 

Radika MK, Anuradha CV. Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues. J Basic Clin Physiol Pharmacol. 2015 Jun 27. [Epub ahead of print]. PMID: 26124049.

" Not dangerous goods.

LKT A1335 AdipoRon Hydrochloride (water soluble) 10 mg 89.9 Adiponectin agonist. ≥98% 483.01 Ambient 4°C Highly soluble in DMSO. Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). "Zhang Y, Zhao J, Li R, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.PMID: 26037251.

 

Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PMID: 24172895.

" Not dangerous goods.

LKT A1335 AdipoRon Hydrochloride (water soluble) 50 mg 359.5 Adiponectin agonist. ≥98% 483.01 Ambient 4°C Highly soluble in DMSO. Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). "Zhang Y, Zhao J, Li R, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.PMID: 26037251.

 

Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PMID: 24172895.

" Not dangerous goods.

LKT A1334 AdipoRon 10 mg 110.1 Adiponectin agonist. 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide 924416-43-3 ≥98% 428.53 Ambient 4°C Soluble in DMSO, 100% ethanol or methanol. Insoluble in water "Zhang Y, Zhao J, Li R, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.PMID: 26037251.

 

Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PMID: 24172895.

" Not dangerous goods.

LKT A1334 AdipoRon 50 mg 440.4 Adiponectin agonist. 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide 924416-43-3 ≥98% 428.53 Ambient 4°C Soluble in DMSO, 100% ethanol or methanol. Insoluble in water "Zhang Y, Zhao J, Li R, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.PMID: 26037251.

 

Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PMID: 24172895.

" Not dangerous goods.

LKT C6801 (S)-CR8 1 mg 94.4 Roscovitine analog; CDK inhibitor. 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine 1084893-56-0 ≥99% 431.54 Ambient 4°C Soluble in DMSO or ethanol "Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

 

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

 

Bukanov NO, Moreno SE, Natoli TA, et al. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle. 2012 Nov 1;11(21):4040-6. PMID: 23032260.

" Not dangerous goods.

LKT C6801 (S)-CR8 5 mg 283.1 Roscovitine analog; CDK inhibitor. 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine 1084893-56-0 ≥99% 431.54 Ambient 4°C Soluble in DMSO or ethanol "Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

 

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

 

Bukanov NO, Moreno SE, Natoli TA, et al. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle. 2012 Nov 1;11(21):4040-6. PMID: 23032260.

" Not dangerous goods.

LKT C6800 (R)-CR8 1 mg 94.4 Roscovitine analog; CDK inhibitor. 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine 294646-77-8 ≥98% 431.54 Ambient 4°C Soluble in DMSO or 100% ethanol "Troadec S, Blairvacq M, Oumata N, et al. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. J Biomed Sci. 2015 Jul 17;22:57. PMID: 26184865.

 

Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

 

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

 

Bettayeb K, Baunbæk D, Delehouze C, et al. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes Cancer. 2010 Apr;1(4):369-80. PMID: 21779453.

 

Bettayeb K, Oumata N, Echalier A, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. PMID: 18574471.

" Not dangerous goods.

LKT C6800 (R)-CR8 5 mg 283.1 Roscovitine analog; CDK inhibitor. 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine 294646-77-8 ≥98% 431.54 Ambient 4°C Soluble in DMSO or 100% ethanol "Troadec S, Blairvacq M, Oumata N, et al. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. J Biomed Sci. 2015 Jul 17;22:57. PMID: 26184865.

 

Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

 

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

 

Bettayeb K, Baunbæk D, Delehouze C, et al. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes Cancer. 2010 Apr;1(4):369-80. PMID: 21779453.

 

Bettayeb K, Oumata N, Echalier A, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. PMID: 18574471.

" Not dangerous goods.

LKT F4445 (R)-FSL-1 100 µg 456.1 Adjuvant; TLR2/6 agonist. "Fibroblast-stimulating Lipopeptide; R-Pam2CGDPKHPKSF; (R)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH

" ≥98% 1666.2 Ambient 4°C Soluble in water (10mg/ml). "Tunis MC, Dawod B, Carson KR, et al. Toll-like receptor 2 activators modulate oral tolerance in mice. Clin Exp Allergy. 2015 Aug 4. [Epub ahead of print]. PMID: 26242919.

 

Lim R, Barker G, Lappas M. The TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88/TRAF6/NF-κB-dependent signalling. Am J Reprod Immunol. 2014 May;71(5):401-17. PMID: 24635133.

 

Buffa V, Klein K, Fischetti L, et al. Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. PLoS One. 2012;7(12):e50529. PMID: 23272062.

 

Kiura K, Hasebe A, Saeki A, et al. In vivo anti- and pro-tumour activities of the TLR2 ligand FSL-1. Immunobiology. 2011 Aug;216(8):891-900. PMID: 21496943.

" Not dangerous goods.

LKT M2077 1-Methoxy-5-methylphenazinium Methyl Sulfate 25 mg 61.8 Electron carrier used to study dehydrogenase electron transfer. 1-Methoxyphenazine methosulfate 65162-13-2 ≥98% 336.36 C15H16N2O5S "C[n+]1c2ccccc2nc3c1cccc3OC.COS(=O)(=O)[O-]

" Ambient "Tantular IS, Kawamoto F. An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency. Trop Med Int Health. 2003 Jun;8(6):569-74. PMID: 12791063.

 

Ikebukuro K, Kohiki Y, Sode K. Amperometric DNA sensor using the pyrroquinoline quinone glucose dehydrogenase-avidin conjugate. Biosens Bioelectron. 2002 Dec;17(11-12):1075-80. PMID: 12392958.

 

Kugler P. Quantitative dehydrogenase histochemistry with exogenous electron carriers (PMS, MPMS, MB). Histochemistry. 1982;75(1):99-112. PMID: 7118585.

" Not dangerous goods.

LKT M2077 1-Methoxy-5-methylphenazinium Methyl Sulfate 100 mg 166.3 Electron carrier used to study dehydrogenase electron transfer. 1-Methoxyphenazine methosulfate 65162-13-2 ≥98% 336.36 C15H16N2O5S "C[n+]1c2ccccc2nc3c1cccc3OC.COS(=O)(=O)[O-]

" Ambient "Tantular IS, Kawamoto F. An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency. Trop Med Int Health. 2003 Jun;8(6):569-74. PMID: 12791063.

 

Ikebukuro K, Kohiki Y, Sode K. Amperometric DNA sensor using the pyrroquinoline quinone glucose dehydrogenase-avidin conjugate. Biosens Bioelectron. 2002 Dec;17(11-12):1075-80. PMID: 12392958.

 

Kugler P. Quantitative dehydrogenase histochemistry with exogenous electron carriers (PMS, MPMS, MB). Histochemistry. 1982;75(1):99-112. PMID: 7118585.

" Not dangerous goods.

LKT M2077 1-Methoxy-5-methylphenazinium Methyl Sulfate 500 mg 617.9 Electron carrier used to study dehydrogenase electron transfer. 1-Methoxyphenazine methosulfate 65162-13-2 ≥98% 336.36 C15H16N2O5S "C[n+]1c2ccccc2nc3c1cccc3OC.COS(=O)(=O)[O-]

" Ambient "Tantular IS, Kawamoto F. An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency. Trop Med Int Health. 2003 Jun;8(6):569-74. PMID: 12791063.

 

Ikebukuro K, Kohiki Y, Sode K. Amperometric DNA sensor using the pyrroquinoline quinone glucose dehydrogenase-avidin conjugate. Biosens Bioelectron. 2002 Dec;17(11-12):1075-80. PMID: 12392958.

 

Kugler P. Quantitative dehydrogenase histochemistry with exogenous electron carriers (PMS, MPMS, MB). Histochemistry. 1982;75(1):99-112. PMID: 7118585.

" Not dangerous goods.

LKT B8377 5-tert-Butoxyquinazoline-2,4-diamine 25 mg 67.4 Diaminoquinazoline derivative. 1009734-33-1 ≥98% 232.29 C12H16N4O Ambient Chao B, Tong XK, Tang W, et al. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem. 2012 Apr 12;55(7):3135-43. PMID: 22448770.

LKT B8377 5-tert-Butoxyquinazoline-2,4-diamine 100 mg 179.8 Diaminoquinazoline derivative. 1009734-33-1 ≥98% 232.29 C12H16N4O Ambient Chao B, Tong XK, Tang W, et al. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem. 2012 Apr 12;55(7):3135-43. PMID: 22448770.

LKT T0140 TAK-632 25 mg 410.1 RAF inhibitor. TAK632 1228591-30-7 ≥98% 554.52 C27H18F4N4O3S Ambient "Nakamura A, Arita T, Tsuchiya S, et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Res. 2013 Dec 1;73(23):7043-55. PMID: 24121489.

 

Okaniwa M, Hirose M, Arita T, et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. J Med Chem. 2013 Aug 22;56(16):6478-94. PMID: 23906342.

" Not dangerous goods.

LKT G1849 Gemifloxacin Mesylate 250 mg 47.3 Fluoroquinolone; bacterial DNA gyrase inhibitor. 210353-53-0 ≥98% 485.49 C18H21FN5O4 CH3SO3 CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O Ambient Ambient "Anzueto A, Miravitlles M. Short-course fluoroquinolone therapy in exacerbations of chronic bronchitis and COPD. Respir Med. 2010 Oct;104(10):1396-403. PMID: 20580215.

 

Lode HM, Schmidt-Ionas M, Stahlmann R. Gemifloxacin for community-acquired pneumonia. Expert Opin Investig Drugs. 2008 May;17(5):779-86. PMID: 18447602.

 

Bhavnani SM, Andes DR. Gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy. 2005 May;25(5):717-40. PMID: 15899734.

" Not dangerous goods.

LKT C2801 Chaetoglobosin A 1 mg 105 Cytotoxic and antifungal activities. (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trione 50335-03-0 ≥99% 528.64 "CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4Cc5c[nH]c6c5cccc6)C)C

" Ambient -20°C Soluble in DMSO, ethanol, methanol. "Zhang G, Zhang Y, Qin J, et al. Antifungal metabolites produced by Chaeyomium globosum No. 04, an endophytic fungus isolated from Ginko biloba. Indian J Microbiol. 2013 Jun; 53(2): 175-180. PMID: 24426105.

" Not dangerous goods.

LKT C2801 Chaetoglobosin A 5 mg 420 Cytotoxic and antifungal activities. (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trione 50335-03-0 ≥99% 528.64 "CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4Cc5c[nH]c6c5cccc6)C)C

" Ambient -20°C Soluble in DMSO, ethanol, methanol. "Zhang G, Zhang Y, Qin J, et al. Antifungal metabolites produced by Chaeyomium globosum No. 04, an endophytic fungus isolated from Ginko biloba. Indian J Microbiol. 2013 Jun; 53(2): 175-180. PMID: 24426105.

" Not dangerous goods.

LKT C2801 Chaetoglobosin A 10 mg 756 Cytotoxic and antifungal activities. (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trione 50335-03-0 ≥99% 528.64 "CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4Cc5c[nH]c6c5cccc6)C)C

" Ambient -20°C Soluble in DMSO, ethanol, methanol. "Zhang G, Zhang Y, Qin J, et al. Antifungal metabolites produced by Chaeyomium globosum No. 04, an endophytic fungus isolated from Ginko biloba. Indian J Microbiol. 2013 Jun; 53(2): 175-180. PMID: 24426105.

" Not dangerous goods.

LKT S0254 Sanguinarine Chloride 5 mg 84 Decreases expression of MMPs, PGE2, and COX-2, and increases TIMP1, TIMP2, and HO-1. 5578-73-4 ≥98% 367.78 "C[n+]1cc2c(ccc3c2OCO3)c4c1c5cc6c(cc5cc4)OCO6.[ClH-]

" Ambient Ambient "Park SY, Jin ML, Kim YH, et al. Sanguinarine inhibits invasiveness and the MMP 9 and COX 2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. Oncol Rep. 2014 Jan;31(1):497-504. PMID: 24220687.

 

Shao J, Liu D, Gong D, et al. Inhibitory effects of sanguinarine against the cyanobacterium Microcystis aeruginosa NIES-843 and possible mechanisms of action. Aquat Toxicol. 2013 Oct 15;142-143:257-63. PMID: 24060579.

 

Dong XZ, Zhang M, Wang K, et al. Sanguinarine inhibits vascular endothelial growth factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells. Biomed Res Int. 2013;2013:517698. PMID: 23762849.

 

Niu X, Fan T, Li W, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. PMID: 23352506.

 

Foss MH, Eun YJ, Grove CI, et al. Inhibitors of bacterial tubulin target bacterial membranes in vivo. Medchemcomm. 2013 Jan 1;4(1):112-119. PMID: 23539337.

 

Choi J, He N, Sung MK, et al. Sanguinarine is an allosteric activator of AMP-activated protein kinase. Biochem Biophys Res Commun. 2011 Sep 23;413(2):259-63. PMID: 21884681.

 

Drsata J, Ulrichová J, Walterová D. Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase. J Enzyme Inhib. 1996;10(4):231-237. PMID: 8872743.

 

Wolff J, Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry. 1993 Dec 7;32(48):13334-9. PMID: 7902132.

" Not dangerous goods.

LKT S0254 Sanguinarine Chloride 25 mg 299.3 Decreases expression of MMPs, PGE2, and COX-2, and increases TIMP1, TIMP2, and HO-1. 5578-73-4 ≥98% 367.78 "C[n+]1cc2c(ccc3c2OCO3)c4c1c5cc6c(cc5cc4)OCO6.[ClH-]

" Ambient Ambient "Park SY, Jin ML, Kim YH, et al. Sanguinarine inhibits invasiveness and the MMP 9 and COX 2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. Oncol Rep. 2014 Jan;31(1):497-504. PMID: 24220687.

 

Shao J, Liu D, Gong D, et al. Inhibitory effects of sanguinarine against the cyanobacterium Microcystis aeruginosa NIES-843 and possible mechanisms of action. Aquat Toxicol. 2013 Oct 15;142-143:257-63. PMID: 24060579.

 

Dong XZ, Zhang M, Wang K, et al. Sanguinarine inhibits vascular endothelial growth factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells. Biomed Res Int. 2013;2013:517698. PMID: 23762849.

 

Niu X, Fan T, Li W, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. PMID: 23352506.

 

Foss MH, Eun YJ, Grove CI, et al. Inhibitors of bacterial tubulin target bacterial membranes in vivo. Medchemcomm. 2013 Jan 1;4(1):112-119. PMID: 23539337.

 

Choi J, He N, Sung MK, et al. Sanguinarine is an allosteric activator of AMP-activated protein kinase. Biochem Biophys Res Commun. 2011 Sep 23;413(2):259-63. PMID: 21884681.

 

Drsata J, Ulrichová J, Walterová D. Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase. J Enzyme Inhib. 1996;10(4):231-237. PMID: 8872743.

 

Wolff J, Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry. 1993 Dec 7;32(48):13334-9. PMID: 7902132.

" Not dangerous goods.

LKT V3455 Vinpocetine 20 mg 99.8 Targets nuclear factor kappa B activation. 42971-09-5 ≥98% 350.46 "CCC12CCCN3C1c4c(c5ccccc5n4C(=C2)C(=O)OCC)CC3

" Store as supplied at ambient temperature. Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (5 mg/ml), ethanol (15 mg/ml) and DMF (3 mg/m). "Hagiwara M, Endo T, Hidaka H.  Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.  Biochem Pharmacol. 1984 Feb 1;33(3):453-7.  PMID: 6322804

 

Molnár P1, Erdö SL.  Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.  Eur J Pharmacol. 1995 Feb 6;273(3):303-6.  PMID: 7737339

 

Gómez CD1, Buijs RM, Sitges M.  The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus.  J Neurochem. 2014 Sep;130(6):770-9. doi: 10.1111/jnc.12784. Epub 2014 Jun 27.  PMID: 24903676

 

Wang H1, Zhang K2, Zhao L3, Tang J3, Gao L3, Wei Z3.  Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury.  Neurosci Lett. 2014 Apr 30;566:247-51. doi: 10.1016/j.neulet.2014.02.045. Epub 2014 Mar 2.  PMID: 24598438

 

Zhao YY1, Yu JZ, Li QY, Ma CG, Lu CZ, Xiao BG.  TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation.  Neuron Glia Biol. 2011 May;7(2-4):187-97. doi: 10.1017/S1740925X12000129. Epub 2012 Jul 6.  PMID: 22874716

 

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, et al. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines, and NF-kB. Chem Biol Interact. 2015 Jul 25;237:9-17. PMID: 25980587" Not dangerous goods.

LKT V3455 Vinpocetine 100 mg 283.5 Targets nuclear factor kappa B activation. 42971-09-5 ≥98% 350.46 "CCC12CCCN3C1c4c(c5ccccc5n4C(=C2)C(=O)OCC)CC3

" Store as supplied at ambient temperature. Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (5 mg/ml), ethanol (15 mg/ml) and DMF (3 mg/m). "Hagiwara M, Endo T, Hidaka H.  Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.  Biochem Pharmacol. 1984 Feb 1;33(3):453-7.  PMID: 6322804

 

Molnár P1, Erdö SL.  Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.  Eur J Pharmacol. 1995 Feb 6;273(3):303-6.  PMID: 7737339

 

Gómez CD1, Buijs RM, Sitges M.  The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus.  J Neurochem. 2014 Sep;130(6):770-9. doi: 10.1111/jnc.12784. Epub 2014 Jun 27.  PMID: 24903676

 

Wang H1, Zhang K2, Zhao L3, Tang J3, Gao L3, Wei Z3.  Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury.  Neurosci Lett. 2014 Apr 30;566:247-51. doi: 10.1016/j.neulet.2014.02.045. Epub 2014 Mar 2.  PMID: 24598438

 

Zhao YY1, Yu JZ, Li QY, Ma CG, Lu CZ, Xiao BG.  TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation.  Neuron Glia Biol. 2011 May;7(2-4):187-97. doi: 10.1017/S1740925X12000129. Epub 2012 Jul 6.  PMID: 22874716

 

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, et al. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines, and NF-kB. Chem Biol Interact. 2015 Jul 25;237:9-17. PMID: 25980587" Not dangerous goods.

LKT Z0222 Zafirlukast 10 mg 31.5 VEGF-C/Nrp2 inhibitor. Leukotriene receptor antagonist. 107753-78-6 ≥98% 575.68 "Cc1ccccc1S(=O)(=O)NC(=O)c2ccc(c(c2)OC)Cc3cn(c4c3cc(cc4)NC(=O)OC5CCCC5)C

" Store desiccated as suppied at Ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (25 mg/ml). "Oda S, Fijiwara R, Kutsuno Y, et al. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metal Dispos. 2015 Jun; 43(6):812-818. PMID: 25834030.

 

Bandaru S, Marri VK, Kasera P, et al. Structure based virtual screening of ligands to identify cysteinyl leukotriene receptor 1 antagonist. Bioinformation. 2014 Oct 30; 10(10):652-657. PMID: 25489175.

 

Kang SH, Shin KC, Kim WS, et al. The preventive effect of topical zafirlukast instillation for peri-implant capsule formation in rabbits. Arch Plast Surg. 2015 Mar; 42(2):179-185. PMID: 25798389." Not dangerous goods.

LKT Z0222 Zafirlukast 50 mg 126 VEGF-C/Nrp2 inhibitor. Leukotriene receptor antagonist. 107753-78-6 ≥98% 575.68 "Cc1ccccc1S(=O)(=O)NC(=O)c2ccc(c(c2)OC)Cc3cn(c4c3cc(cc4)NC(=O)OC5CCCC5)C

" Store desiccated as suppied at Ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (25 mg/ml). "Oda S, Fijiwara R, Kutsuno Y, et al. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metal Dispos. 2015 Jun; 43(6):812-818. PMID: 25834030.

 

Bandaru S, Marri VK, Kasera P, et al. Structure based virtual screening of ligands to identify cysteinyl leukotriene receptor 1 antagonist. Bioinformation. 2014 Oct 30; 10(10):652-657. PMID: 25489175.

 

Kang SH, Shin KC, Kim WS, et al. The preventive effect of topical zafirlukast instillation for peri-implant capsule formation in rabbits. Arch Plast Surg. 2015 Mar; 42(2):179-185. PMID: 25798389." Not dangerous goods.

LKT Z0222 Zafirlukast 100 mg 210 VEGF-C/Nrp2 inhibitor. Leukotriene receptor antagonist. 107753-78-6 ≥98% 575.68 "Cc1ccccc1S(=O)(=O)NC(=O)c2ccc(c(c2)OC)Cc3cn(c4c3cc(cc4)NC(=O)OC5CCCC5)C

" Store desiccated as suppied at Ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (25 mg/ml). "Oda S, Fijiwara R, Kutsuno Y, et al. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metal Dispos. 2015 Jun; 43(6):812-818. PMID: 25834030.

 

Bandaru S, Marri VK, Kasera P, et al. Structure based virtual screening of ligands to identify cysteinyl leukotriene receptor 1 antagonist. Bioinformation. 2014 Oct 30; 10(10):652-657. PMID: 25489175.

 

Kang SH, Shin KC, Kim WS, et al. The preventive effect of topical zafirlukast instillation for peri-implant capsule formation in rabbits. Arch Plast Surg. 2015 Mar; 42(2):179-185. PMID: 25798389." Not dangerous goods.

LKT U8000 U-74389G 25 mg 31.5 Antioxidant shown to improve renal function. U74389G, (Z)-2-butenedioate 153190-29-5 ≥95% 726.92 Store desiccated as supplied at ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient -20°C Soluble in DMSO(25 mg/ml) and ethanol (25 mg/ml). "Bonatsos V, Kappas I, Birbas K, et al. Effects of U-74389G (21-Lazaroid) and ascorbic acid on liver recovery after acute ischemia and reperfusion in rats. In Vivo. 2015 Sep-Oct; 29(5):585-594. PMID: 26359418.

 

Tsompos C, Panoulis C, Toutouzas K, et al. The effect of the antioxidant drug “U-74389G” on creatinine leveLSuring ischemia reperfusion injury in rats. Curr Urol. 2016 May; 9(2):73-78. PMID: 27390579.

 

Margonis GA, Christoloukas N, Antoniou E, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb; 193(2):667-674. PMID: 25277360." Not dangerous goods.

LKT U8000 U-74389G 100 mg 105 Antioxidant shown to improve renal function. U74389G, (Z)-2-butenedioate 153190-29-5 ≥95% 726.92 Store desiccated as supplied at ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient -20°C Soluble in DMSO(25 mg/ml) and ethanol (25 mg/ml). "Bonatsos V, Kappas I, Birbas K, et al. Effects of U-74389G (21-Lazaroid) and ascorbic acid on liver recovery after acute ischemia and reperfusion in rats. In Vivo. 2015 Sep-Oct; 29(5):585-594. PMID: 26359418.

 

Tsompos C, Panoulis C, Toutouzas K, et al. The effect of the antioxidant drug “U-74389G” on creatinine leveLSuring ischemia reperfusion injury in rats. Curr Urol. 2016 May; 9(2):73-78. PMID: 27390579.

 

Margonis GA, Christoloukas N, Antoniou E, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb; 193(2):667-674. PMID: 25277360." Not dangerous goods.

LKT R5745 Rolipram 10 mg 78.8 ZK62711 61413-54-5 ≥98% 275.35 "COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

" Store desiccated as supplied at ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (warm 25mg/ml), ethanol (25 mg/ml warm). "Hu S, Cao Q, Xu P, et al. Rolipram stimulates angiogensis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats. Exp Ther Med. 2016 Mar; 11(3):1005-1010. PMID: 26998028.

 

Li YF, Huang Y, Amsdell S, et al. Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology. 2009 Oct; 34(11):2404-2419. PMID: 19516250." Not dangerous goods.

LKT R5745 Rolipram 25 mg 157.5 ZK62711 61413-54-5 ≥98% 275.35 "COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

" Store desiccated as supplied at ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (warm 25mg/ml), ethanol (25 mg/ml warm). "Hu S, Cao Q, Xu P, et al. Rolipram stimulates angiogensis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats. Exp Ther Med. 2016 Mar; 11(3):1005-1010. PMID: 26998028.

 

Li YF, Huang Y, Amsdell S, et al. Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology. 2009 Oct; 34(11):2404-2419. PMID: 19516250." Not dangerous goods.

LKT R5745 Rolipram 100 mg 504 ZK62711 61413-54-5 ≥98% 275.35 "COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

" Store desiccated as supplied at ambient temperature for up to 2 years.  Solution at -20 oC for up to 3 months. Ambient Ambient Soluble in DMSO (warm 25mg/ml), ethanol (25 mg/ml warm). "Hu S, Cao Q, Xu P, et al. Rolipram stimulates angiogensis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats. Exp Ther Med. 2016 Mar; 11(3):1005-1010. PMID: 26998028.

 

Li YF, Huang Y, Amsdell S, et al. Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology. 2009 Oct; 34(11):2404-2419. PMID: 19516250." Not dangerous goods.

LKT R5602 Ro 20-1724 100 mg 94.5 Phosphodiesterase inhibitor that produces anti-inflammatory effects. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone 29925-17-5 ≥98% 278.35 "CCCCOc1cc(ccc1OC)CC2CNC(=O)N2

" Store desiccated as supplied at ambient temperature for up to 5 years.  Solution at -20oC for up to 6 months. Ambient Ambient Soluble in DMSO (200 mg/ml), ethanol (40 mg/ml). "Sharma V, Bala A, Deshmukh R, et al. Neuroprotective effect of Ro-20-1724 a phosphodiesterase4 inhibitor against intracerebroventricular streptozocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012 Apr; 101(2):239-245. PMID: 2285388.

 

Clayton R, Dick C, Mackenzie A, et al. The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respir Res. 2004 May 5; 5(1):4. PMID: 15169552." Not dangerous goods.

LKT R5602 Ro 20-1724 250 mg 189 Phosphodiesterase inhibitor that produces anti-inflammatory effects. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone 29925-17-5 ≥98% 278.35 "CCCCOc1cc(ccc1OC)CC2CNC(=O)N2

" Store desiccated as supplied at ambient temperature for up to 5 years.  Solution at -20oC for up to 6 months. Ambient Ambient Soluble in DMSO (200 mg/ml), ethanol (40 mg/ml). "Sharma V, Bala A, Deshmukh R, et al. Neuroprotective effect of Ro-20-1724 a phosphodiesterase4 inhibitor against intracerebroventricular streptozocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012 Apr; 101(2):239-245. PMID: 2285388.

 

Clayton R, Dick C, Mackenzie A, et al. The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respir Res. 2004 May 5; 5(1):4. PMID: 15169552." Not dangerous goods.

LKT W9602 WY-14643 10 mg 31.5 A peroxisome proliferator-activated receptor agonist. Pirinixic Acid, WY14643 50892-23-4 ≥98% 323.8 "Cc1cccc(c1C)Nc2cc(nc(n2)SCC(=O)O)Cl

" Store desiccated as supplied at ambient temp. for up to 5 years.  Solution at -20 oC aro up to 6 months Ambient Ambient DMSO (40 mg/ml) "Szalowska E, Tesfay HA, van Hijum SA, Kersten S. Transcriptomic signatures of peroxisome proliferator-activated receptor  (PPAR) in different mouse liver models identify novel aspects of its biology. BMC Genomics. 2014 Dec; 15(1): 1106. PMID: 25511156.

 

Mussbacher M, Stessel H, Wolkart G, et al. Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. J Mol Cell Cardiol. 2014 Dec; 77:11-19. PMID: 25285770." Not dangerous goods.

LKT W9602 WY-14643 50 mg 78.8 A peroxisome proliferator-activated receptor agonist. Pirinixic Acid, WY14643 50892-23-4 ≥98% 323.8 "Cc1cccc(c1C)Nc2cc(nc(n2)SCC(=O)O)Cl

" Store desiccated as supplied at ambient temp. for up to 5 years.  Solution at -20 oC aro up to 6 months Ambient Ambient DMSO (40 mg/ml) "Szalowska E, Tesfay HA, van Hijum SA, Kersten S. Transcriptomic signatures of peroxisome proliferator-activated receptor  (PPAR) in different mouse liver models identify novel aspects of its biology. BMC Genomics. 2014 Dec; 15(1): 1106. PMID: 25511156.

 

Mussbacher M, Stessel H, Wolkart G, et al. Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. J Mol Cell Cardiol. 2014 Dec; 77:11-19. PMID: 25285770." Not dangerous goods.

LKT V1871 Veratridine 10 mg 94.5 Binds to neurotoxin receptor site 2 on voltage-gated sodium channels. 71-62-5 ≥98% 673.8 "CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)c8ccc(c(c8)OC)OC)O)C)O)O)O)(C)O

" Store as supplied at -20 oC for up to 2 years.  Store in solutions at -20 oC for up to 2 months. Ambient -20°C DMSO (25 mg/ml), ethanol (25 mg/ml) "Abdullah A, Sane S, Branick KA, et al. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15; 6(27): 23561-23581. PMID: 26188124.

 

 

Fekete A, Franklin L, Ikemoto T, Rózsa B, Lendvai B, Sylvester Vizi E, Zelles T.  Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.  J Neurochem. 2009 Nov;111(3):745-56. doi: 10.1111/j.1471-4159.2009.06368.x. Epub 2009 Aug 31  PMID: 19719824.

 

Chen M1, Xiao CY, Hashizume H, Abiko Y.  Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes.  Eur J Pharmacol. 1997 Aug 27;333(2-3):261-8.  PMID: 9314043.

 

Koike T, Tanaka S, Oda1 T, Ninomiya T.  Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro.  Brain Res Bull. 2000 Mar 1;51(4):345-55,  PMID: 10704786" "UN number: 1544     Class: 6.1     Packing Group: I

Proper shipping name: Alkaloids, solid, n.o.s. (Veratridine)"

LKT V1871 Veratridine 25 mg 194.3 Binds to neurotoxin receptor site 2 on voltage-gated sodium channels. 71-62-5 ≥98% 673.8 "CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)c8ccc(c(c8)OC)OC)O)C)O)O)O)(C)O

" Store as supplied at -20 oC for up to 2 years.  Store in solutions at -20 oC for up to 2 months. Ambient -20°C DMSO (25 mg/ml), ethanol (25 mg/ml) "Abdullah A, Sane S, Branick KA, et al. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15; 6(27): 23561-23581. PMID: 26188124.

 

 

Fekete A, Franklin L, Ikemoto T, Rózsa B, Lendvai B, Sylvester Vizi E, Zelles T.  Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.  J Neurochem. 2009 Nov;111(3):745-56. doi: 10.1111/j.1471-4159.2009.06368.x. Epub 2009 Aug 31  PMID: 19719824.

 

Chen M1, Xiao CY, Hashizume H, Abiko Y.  Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes.  Eur J Pharmacol. 1997 Aug 27;333(2-3):261-8.  PMID: 9314043.

 

Koike T, Tanaka S, Oda1 T, Ninomiya T.  Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro.  Brain Res Bull. 2000 Mar 1;51(4):345-55,  PMID: 10704786" "UN number: 1544     Class: 6.1     Packing Group: I

Proper shipping name: Alkaloids, solid, n.o.s. (Veratridine)"

LKT V1871 Veratridine 100 mg 577.5 Binds to neurotoxin receptor site 2 on voltage-gated sodium channels. 71-62-5 ≥98% 673.8 "CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)c8ccc(c(c8)OC)OC)O)C)O)O)O)(C)O

" Store as supplied at -20 oC for up to 2 years.  Store in solutions at -20 oC for up to 2 months. Ambient -20°C DMSO (25 mg/ml), ethanol (25 mg/ml) "Abdullah A, Sane S, Branick KA, et al. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15; 6(27): 23561-23581. PMID: 26188124.

 

 

Fekete A, Franklin L, Ikemoto T, Rózsa B, Lendvai B, Sylvester Vizi E, Zelles T.  Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.  J Neurochem. 2009 Nov;111(3):745-56. doi: 10.1111/j.1471-4159.2009.06368.x. Epub 2009 Aug 31  PMID: 19719824.

 

Chen M1, Xiao CY, Hashizume H, Abiko Y.  Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes.  Eur J Pharmacol. 1997 Aug 27;333(2-3):261-8.  PMID: 9314043.

 

Koike T, Tanaka S, Oda1 T, Ninomiya T.  Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro.  Brain Res Bull. 2000 Mar 1;51(4):345-55,  PMID: 10704786" "UN number: 1544     Class: 6.1     Packing Group: I

Proper shipping name: Alkaloids, solid, n.o.s. (Veratridine)"

LKT S6168 Spirapril Hydrochloride 25 mg 102.9 ACE inhibitor. 94841-17-5 503.07 C22H30N2O5S2 HCl CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3 Ambient Ambient "Noble S, Sorkin EM. Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension. Drugs. 1995 May;49(5):750-66. PMID: 7601014.

 

Sybertz EJ, Watkins RW, Ahn HS, et al. Pharmacologic, metabolic, and toxicologic profile of spirapril (SCH 33844), a new angiotensin converting inhibitor. J Cardiovasc Pharmacol. 1987;10 Suppl 7:S105-8. PMID: 2485040.

" Not dangerous goods.

LKT L3455 α-Linolenic Acid 10 mg 50.4 An omega-3 fatty acid. 9Z,12Z,15Z-Octadecatrienoic acid 463-40-1 ≥98% 278.44 "CCC=CCC=CCC=CCCCCCCCC(=O)O

" Ambient -20°C "Lanzmann-Petithory D  Alpha-linoleni acid and cardiovascular ldiseases.  J, Nutr ealth Aging.  2001; 5(3):179-83.  PMID: 11458289.

 

" Not dangerous goods.

LKT L3455 α-Linolenic Acid 25 mg 89.3 An omega-3 fatty acid. 9Z,12Z,15Z-Octadecatrienoic acid 463-40-1 ≥98% 278.44 "CCC=CCC=CCC=CCCCCCCCC(=O)O

" Ambient -20°C "Lanzmann-Petithory D  Alpha-linoleni acid and cardiovascular ldiseases.  J, Nutr ealth Aging.  2001; 5(3):179-83.  PMID: 11458289.

 

" Not dangerous goods.

LKT L3455 α-Linolenic Acid 100 mg 262.5 An omega-3 fatty acid. 9Z,12Z,15Z-Octadecatrienoic acid 463-40-1 ≥98% 278.44 "CCC=CCC=CCC=CCCCCCCCC(=O)O

" Ambient -20°C "Lanzmann-Petithory D  Alpha-linoleni acid and cardiovascular ldiseases.  J, Nutr ealth Aging.  2001; 5(3):179-83.  PMID: 11458289.

 

" Not dangerous goods.

LKT B4514 Bleomycin A5 Hydrochloride Cu 1 mg 78.8 Induces apoptosis, DNA cleavage and strand breaks. ≥85% "Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

 

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

 

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

 

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

" Not dangerous goods.

LKT B4514 Bleomycin A5 Hydrochloride Cu 5 mg 241.5 Induces apoptosis, DNA cleavage and strand breaks. ≥85% "Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

 

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

 

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

 

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

" Not dangerous goods.

LKT B4514 Bleomycin A5 Hydrochloride Cu 10 mg 420 Induces apoptosis, DNA cleavage and strand breaks. ≥85% "Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

 

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

 

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

 

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

" Not dangerous goods.

LKT B4514 Bleomycin A5 Hydrochloride Cu 25 mg 724.5 Induces apoptosis, DNA cleavage and strand breaks. ≥85% "Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

 

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

 

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

 

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

" Not dangerous goods.

LKT T0205 3”,4”-Dehydropaclitaxel C 5 mg 1155 Semi-synthetic taxane. 3”,4”-Dehydrotaxol C ≥98% 845.93 -20°C Mendoza A, Ishihara Y, Baran PS. Scalable enantioselective total synthesis of taxanes. Nat Chem. 2011 Nov 6; 4(1):21-25. PMID: 22169867. Not dangerous goods.

LKT T0205 3”,4”-Dehydropaclitaxel C 25 mg 4725 Semi-synthetic taxane. 3”,4”-Dehydrotaxol C ≥98% 845.93 -20°C Mendoza A, Ishihara Y, Baran PS. Scalable enantioselective total synthesis of taxanes. Nat Chem. 2011 Nov 6; 4(1):21-25. PMID: 22169867. Not dangerous goods.

LKT T0205 3”,4”-Dehydropaclitaxel C 1 mg 336 Semi-synthetic taxane. 3”,4”-Dehydrotaxol C ≥98% 845.93 -20°C Mendoza A, Ishihara Y, Baran PS. Scalable enantioselective total synthesis of taxanes. Nat Chem. 2011 Nov 6; 4(1):21-25. PMID: 22169867. Not dangerous goods.

LKT F4581 5-Fluorocytosine 500 mg 42 Synthetic antifungal. 6-amino-5-fluoro-2(1H)-pyrimidinone Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 2022-85-7 ≥98% 129.09 "c1c(c(nc(=O)[nH]1)N)F

" Ambient "Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.

 

Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.

 

O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314." Not dangerous goods.

LKT F4581 5-Fluorocytosine 1 g 73.5 Synthetic antifungal. 6-amino-5-fluoro-2(1H)-pyrimidinone Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 2022-85-7 ≥98% 129.09 "c1c(c(nc(=O)[nH]1)N)F

" Ambient "Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.

 

Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.

 

O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314." Not dangerous goods.

LKT F4581 5-Fluorocytosine 5 g 283.5 Synthetic antifungal. 6-amino-5-fluoro-2(1H)-pyrimidinone Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 2022-85-7 ≥98% 129.09 "c1c(c(nc(=O)[nH]1)N)F

" Ambient "Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.

 

Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.

 

O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314." Not dangerous goods.

LKT F4581 5-Fluorocytosine 10 g 341.3 Synthetic antifungal. 6-amino-5-fluoro-2(1H)-pyrimidinone Flucytosine, Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915 2022-85-7 ≥98% 129.09 "c1c(c(nc(=O)[nH]1)N)F

" Ambient "Huang TT, Parab S, Burnett R, et al. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.

 

Davoudi N, Khamesipour A, Mahboudi F, McMaster WR. A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice. PLoS Negl Trop Dis. 2014 May 29; 8(5):e2785. PMID: 24873970.

 

O’Connor L, Livermore J, Sharp AD, et al. Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-361. PMID: 23599314." Not dangerous goods.

LKT P1760 Peptide T 5 mg 367.5 Peptide fragment of HIV-1 gp120. "N-(N-(N2-(N-(N-(N-(N-L-alanyl-L- seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-L-Threonine

" 106362-32-7 ≥98% 857.86 C35H55N9O16 CC(C(C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CO)NC(=O)C(C)N)O Ambient -20°C "Paoletti I, De Gregorio V, Baroni A, et al. Amygdalin analogues inhibit IFN-γ signalling and reduce the inflammatory response in human epidermal keratinocytes. Inflammation. 2013 Dec;36(6):1316-26. PMID: 23933845.

 

D'ursi A, Caliendo G, Perissutti E, et al. Conformation-activity relationship of peptide T and new pseudocyclic hexapeptide analogs. J Pept Sci. 2007 Jun;13(6):413-21. PMID: 17486694.

 

Polianova MT, Ruscetti FW, Pert CB, et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 Aug;67(2):83-92. PMID: 16002156.

 

Ruff MR, Melendez-Guerrero LM, Yang QE, et al. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 2001 Oct;52(1):63-75. PMID: 11530189.

 

Heseltine PN, Goodkin K, Atkinson JH, et al. Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment. Arch Neurol. 1998 Jan;55(1):41-51. PMID: 9443710.

"

LKT A5477 Antide Acetate  0.5 mg 102.9 GnRH antagonist. 112568-12-4 ≥95% 1591.32 C82H108ClN17O14 CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCCNC(=O)C2=CN=CC=C2)NC(=O)C(CCCCNC(=O)C3=CN=CC=C3)NC(=O)C(CO)NC(=O)C(CC4=CN=CC=C4)NC(=O)C(CC5=CC=C(C=C5)Cl)NC(=O)C(CC6=CC7=CC=CC=C7C=C6)NC(=O)C Ambient -20°C "Attaman J, Arbogast LK, Friedman CI, et al. Effect of gonadotropin-releasing hormone antagonist on primordial follicle survival in the primate ovary. J Reprod Med. 2014 Mar-Apr;59(3-4):103-9. PMID: 24724216.

 

Ziegler SG, Thornton JE. Low luteinizing hormone enhances spatial memory and has protective effects on memory loss in rats. Horm Behav. 2010 Nov;58(5):705-13. PMID: 20691694.

" Repr. Cat. 1, Repr. Cat. 2 Not dangerous goods.

LKT A5477 Antide Acetate  1 mg 183.8 GnRH antagonist. 112568-12-4 ≥95% 1591.32 C82H108ClN17O14 CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCCNC(=O)C2=CN=CC=C2)NC(=O)C(CCCCNC(=O)C3=CN=CC=C3)NC(=O)C(CO)NC(=O)C(CC4=CN=CC=C4)NC(=O)C(CC5=CC=C(C=C5)Cl)NC(=O)C(CC6=CC7=CC=CC=C7C=C6)NC(=O)C Ambient -20°C "Attaman J, Arbogast LK, Friedman CI, et al. Effect of gonadotropin-releasing hormone antagonist on primordial follicle survival in the primate ovary. J Reprod Med. 2014 Mar-Apr;59(3-4):103-9. PMID: 24724216.

 

Ziegler SG, Thornton JE. Low luteinizing hormone enhances spatial memory and has protective effects on memory loss in rats. Horm Behav. 2010 Nov;58(5):705-13. PMID: 20691694.

" Repr. Cat. 1, Repr. Cat. 2 Not dangerous goods.

LKT A5477 Antide Acetate  2.5 mg 367.5 GnRH antagonist. 112568-12-4 ≥95% 1591.32 C82H108ClN17O14 CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCCNC(=O)C2=CN=CC=C2)NC(=O)C(CCCCNC(=O)C3=CN=CC=C3)NC(=O)C(CO)NC(=O)C(CC4=CN=CC=C4)NC(=O)C(CC5=CC=C(C=C5)Cl)NC(=O)C(CC6=CC7=CC=CC=C7C=C6)NC(=O)C Ambient -20°C "Attaman J, Arbogast LK, Friedman CI, et al. Effect of gonadotropin-releasing hormone antagonist on primordial follicle survival in the primate ovary. J Reprod Med. 2014 Mar-Apr;59(3-4):103-9. PMID: 24724216.

 

Ziegler SG, Thornton JE. Low luteinizing hormone enhances spatial memory and has protective effects on memory loss in rats. Horm Behav. 2010 Nov;58(5):705-13. PMID: 20691694.

" Repr. Cat. 1, Repr. Cat. 2 Not dangerous goods.

LKT L9880 Lysipressin Acetate 1 mg 52.5 Peptide found in marsupials and pigs, involved in vascular contraction; VP/V2 agonist. Lypressin, (8-Lysine)vasopressin, Diapid, Pitressin, Postacton, Syntopressin, Vasophysin 50-57-7 ≥95% 1056.22 C46H65N13O12S2 CC(=O)O.C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)N Ambient -20°C "László F, Karácsony G, Pávó I, et al. Aggressive role of vasopressin in development of different gastric lesions in rats. Eur J Pharmacol. 1994 Jun 2;258(1-2):15-22. PMID: 7925594.

 

Gorbulev V, Büchner H, Akhundova A, et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7. PMID: 8393786.

 

Crankshaw D. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle. Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8. PMID: 2625135.

 

Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID: 3147712.

" Xn

LKT L9880 Lysipressin Acetate 5 mg 207.9 Peptide found in marsupials and pigs, involved in vascular contraction; VP/V2 agonist. Lypressin, (8-Lysine)vasopressin, Diapid, Pitressin, Postacton, Syntopressin, Vasophysin 50-57-7 ≥95% 1056.22 C46H65N13O12S2 CC(=O)O.C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)N Ambient -20°C "László F, Karácsony G, Pávó I, et al. Aggressive role of vasopressin in development of different gastric lesions in rats. Eur J Pharmacol. 1994 Jun 2;258(1-2):15-22. PMID: 7925594.

 

Gorbulev V, Büchner H, Akhundova A, et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7. PMID: 8393786.

 

Crankshaw D. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle. Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8. PMID: 2625135.

 

Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID: 3147712.

" Xn

LKT S0049 Salmon Calcitonin Acetate 0.5 mg 89.3 Peptide, involved in feeding behavior and insulin signaling. 47931-85-1 ≥95% 3431.9 C145H240N44O48S2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CO)N)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N)C(C)O)CO Ambient -20°C "Feigh M, Andreassen KV, Hjuler ST, et al. Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. Menopause. 2013 Jul;20(7):785-94. PMID: 23793169.

 

Chen-An P, Andreassen KV, Henriksen K, et al. The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. PLoS One. 2012;7(6):e40081. PMID: 22768225.

 

Nielsen RH, Bay-Jensen AC, Byrjalsen I, et al. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarthritis Cartilage. 2011 Apr;19(4):466-73. PMID: 21251986.

" T

LKT S0049 Salmon Calcitonin Acetate 1 mg 157.5 Peptide, involved in feeding behavior and insulin signaling. 47931-85-1 ≥95% 3431.9 C145H240N44O48S2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CO)N)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N)C(C)O)CO Ambient -20°C "Feigh M, Andreassen KV, Hjuler ST, et al. Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. Menopause. 2013 Jul;20(7):785-94. PMID: 23793169.

 

Chen-An P, Andreassen KV, Henriksen K, et al. The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. PLoS One. 2012;7(6):e40081. PMID: 22768225.

 

Nielsen RH, Bay-Jensen AC, Byrjalsen I, et al. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarthritis Cartilage. 2011 Apr;19(4):466-73. PMID: 21251986.

" T

LKT S0049 Salmon Calcitonin Acetate 2.5 mg 315 Peptide, involved in feeding behavior and insulin signaling. 47931-85-1 ≥95% 3431.9 C145H240N44O48S2 CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CO)N)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N)C(C)O)CO Ambient -20°C "Feigh M, Andreassen KV, Hjuler ST, et al. Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. Menopause. 2013 Jul;20(7):785-94. PMID: 23793169.

 

Chen-An P, Andreassen KV, Henriksen K, et al. The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. PLoS One. 2012;7(6):e40081. PMID: 22768225.

 

Nielsen RH, Bay-Jensen AC, Byrjalsen I, et al. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarthritis Cartilage. 2011 Apr;19(4):466-73. PMID: 21251986.

" T

LKT T3098 Thymosin β-4 Acetate 1 mg 126 Endogenous peptide; actin polymerization inhibitor. 77591-33-4 ≥95% 4963.49 C212H350N56O78S CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(C(C)CC)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Qian L, Huang Y, Spencer CI, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31;485(7400):593-8. PMID: 22522929.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT T3098 Thymosin β-4 Acetate 10 mg 472.5 Endogenous peptide; actin polymerization inhibitor. 77591-33-4 ≥95% 4963.49 C212H350N56O78S CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(C(C)CC)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Qian L, Huang Y, Spencer CI, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31;485(7400):593-8. PMID: 22522929.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT T3098 Thymosin β-4 Acetate 50 mg 1260 Endogenous peptide; actin polymerization inhibitor. 77591-33-4 ≥95% 4963.49 C212H350N56O78S CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(C(C)CC)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Qian L, Huang Y, Spencer CI, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31;485(7400):593-8. PMID: 22522929.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT T3097 Thymosin α-1 Acetate 1 mg 126 Endogenous peptide, involved in hormone regulation. 62304-98-7 ≥95% 3108.3 C129H215N33O55 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Lai CL, Wu PC. Antiviral treatment for chronic hepatitis B. Hong Kong Med J. 1997 Sep;3(3):289-296. PMID: 11847374.

 

Molinero P, Soutto M, Benot S, et al. Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans. J Neuroimmunol. 2000 Mar 1;103(2):180-8. PMID: 10696913.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT T3097 Thymosin α-1 Acetate 10 mg 420 Endogenous peptide, involved in hormone regulation. 62304-98-7 ≥95% 3108.3 C129H215N33O55 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Lai CL, Wu PC. Antiviral treatment for chronic hepatitis B. Hong Kong Med J. 1997 Sep;3(3):289-296. PMID: 11847374.

 

Molinero P, Soutto M, Benot S, et al. Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans. J Neuroimmunol. 2000 Mar 1;103(2):180-8. PMID: 10696913.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT T3097 Thymosin α-1 Acetate 50 mg 1312.5 Endogenous peptide, involved in hormone regulation. 62304-98-7 ≥95% 3108.3 C129H215N33O55 CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C Ambient -20°C "Lai CL, Wu PC. Antiviral treatment for chronic hepatitis B. Hong Kong Med J. 1997 Sep;3(3):289-296. PMID: 11847374.

 

Molinero P, Soutto M, Benot S, et al. Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans. J Neuroimmunol. 2000 Mar 1;103(2):180-8. PMID: 10696913.

 

Wolfe MW, Vakharia DD, Wise TH, et al. Characterization of secretion of thymosin alpha 1 and thymosin beta 4 during prepuberty, estrus and pregnancy in the bovine female. Domest Anim Endocrinol. 1989 Jan;6(1):71-8. PMID: 2917466.

"

LKT B0026 Bafilomycin B1 5 mg 720.3 Macrolide; vacuolar H+-ATPase inhibitor. "Hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)carbonyl)-2-methoxy-24-methyl- 

" Setamycin 88899-56-3 ≥97% 815.99 C44H65NO13 CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C Ambient -20°C Soluble in methanol. "Schachtschabel D, Arentshorst M, Lagendijk EL, et al. Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger. Fungal Genet Biol. 2012 Apr;49(4):284-93. PMID: 22222772.

 

Hettiarachchi KD, Zimmet PZ, Danial NN, et al. Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas. Exp Toxicol Pathol. 2008 Aug;60(4-5):295-306. PMID: 18486461.

" T+ "UN number: 3462     Class: 6.1     Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Bafilomycin B1)"

LKT S1969 Sermorelin Acetate 1 mg 186.9 Synthetic peptide, GHRH analog; GHRH agonist. GHRH(1-29)NH2 86168-78-7 ≥95% 3358.03 C149H246N44O42S CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Stepień T, Sacewicz M, Lawnicka H, et al. Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. Neuropeptides. 2009 Oct;43(5):397-400. PMID: 19747727.

 

Khorram O, Yeung M, Vu L, et al. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997 Nov;82(11):3590-6. PMID: 9360512.

 

Estévez MD, Alfonso A, Vieytes MR, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. Inflamm Res. 1995 Feb;44(2):87-91. PMID: 7544679.

 

Sato M, Chihara K, Kita T, et al. Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats. Neuroendocrinology. 1989 Aug;50(2):139-51. PMID: 2571099.

"

LKT S1969 Sermorelin Acetate 5 mg 747.6 Synthetic peptide, GHRH analog; GHRH agonist. GHRH(1-29)NH2 86168-78-7 ≥95% 3358.03 C149H246N44O42S CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Stepień T, Sacewicz M, Lawnicka H, et al. Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. Neuropeptides. 2009 Oct;43(5):397-400. PMID: 19747727.

 

Khorram O, Yeung M, Vu L, et al. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997 Nov;82(11):3590-6. PMID: 9360512.

 

Estévez MD, Alfonso A, Vieytes MR, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. Inflamm Res. 1995 Feb;44(2):87-91. PMID: 7544679.

 

Sato M, Chihara K, Kita T, et al. Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats. Neuroendocrinology. 1989 Aug;50(2):139-51. PMID: 2571099.

"

LKT S1969 Sermorelin Acetate 10 mg 1275.8 Synthetic peptide, GHRH analog; GHRH agonist. GHRH(1-29)NH2 86168-78-7 ≥95% 3358.03 C149H246N44O42S CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Stepień T, Sacewicz M, Lawnicka H, et al. Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. Neuropeptides. 2009 Oct;43(5):397-400. PMID: 19747727.

 

Khorram O, Yeung M, Vu L, et al. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997 Nov;82(11):3590-6. PMID: 9360512.

 

Estévez MD, Alfonso A, Vieytes MR, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. Inflamm Res. 1995 Feb;44(2):87-91. PMID: 7544679.

 

Sato M, Chihara K, Kita T, et al. Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats. Neuroendocrinology. 1989 Aug;50(2):139-51. PMID: 2571099.

"

LKT D1775 Deslorelin Acetate    1 mg 162 Peptide; GnRH agonist. 57773-65-6 ≥95% 1282.47 C64H83N17O12 CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8 Ambient -20°C "Marino G, Rizzo S, Quartuccio M, et al. Deslorelin Implants in Pre-pubertal Female Dogs: Short- and Long-Term Effects on the Genital Tract. Reprod Domest Anim. 2014 Apr;49(2):297-301. PMID: 24467617.

 

Goericke-Pesch S, Georgiev P, Fasulkov I, et al. Basal testosterone concentrations after the application of a slow-release GnRH agonist implant are associated with a loss of response to buserelin, a short-term GnRH agonist, in the tom cat. Theriogenology. 2013 Jul 1;80(1):65-9. PMID: 23622940.

 

Polisca A, Orlandi R, Troisi A, et al. Clinical efficacy of the GnRH agonist (deslorelin) in dogs affected by benign prostatic hyperplasia and evaluation of prostatic blood flow by Doppler ultrasound. Reprod Domest Anim. 2013 Aug;48(4):673-80. PMID: 23320475.

 

Wolf T, Meyer H, Kutzler M. Litter size response to oestrous induction with deslorelin (Ovuplant®) in dogs. Reprod Domest Anim. 2012 Dec;47 Suppl 6:387-8. PMID: 23279545.

" T, Repr.

LKT D1775 Deslorelin Acetate    5 mg 279 Peptide; GnRH agonist. 57773-65-6 ≥95% 1282.47 C64H83N17O12 CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8 Ambient -20°C "Marino G, Rizzo S, Quartuccio M, et al. Deslorelin Implants in Pre-pubertal Female Dogs: Short- and Long-Term Effects on the Genital Tract. Reprod Domest Anim. 2014 Apr;49(2):297-301. PMID: 24467617.

 

Goericke-Pesch S, Georgiev P, Fasulkov I, et al. Basal testosterone concentrations after the application of a slow-release GnRH agonist implant are associated with a loss of response to buserelin, a short-term GnRH agonist, in the tom cat. Theriogenology. 2013 Jul 1;80(1):65-9. PMID: 23622940.

 

Polisca A, Orlandi R, Troisi A, et al. Clinical efficacy of the GnRH agonist (deslorelin) in dogs affected by benign prostatic hyperplasia and evaluation of prostatic blood flow by Doppler ultrasound. Reprod Domest Anim. 2013 Aug;48(4):673-80. PMID: 23320475.

 

Wolf T, Meyer H, Kutzler M. Litter size response to oestrous induction with deslorelin (Ovuplant®) in dogs. Reprod Domest Anim. 2012 Dec;47 Suppl 6:387-8. PMID: 23279545.

" T, Repr.

LKT D1775 Deslorelin Acetate    10 mg 420 Peptide; GnRH agonist. 57773-65-6 ≥95% 1282.47 C64H83N17O12 CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8 Ambient -20°C "Marino G, Rizzo S, Quartuccio M, et al. Deslorelin Implants in Pre-pubertal Female Dogs: Short- and Long-Term Effects on the Genital Tract. Reprod Domest Anim. 2014 Apr;49(2):297-301. PMID: 24467617.

 

Goericke-Pesch S, Georgiev P, Fasulkov I, et al. Basal testosterone concentrations after the application of a slow-release GnRH agonist implant are associated with a loss of response to buserelin, a short-term GnRH agonist, in the tom cat. Theriogenology. 2013 Jul 1;80(1):65-9. PMID: 23622940.

 

Polisca A, Orlandi R, Troisi A, et al. Clinical efficacy of the GnRH agonist (deslorelin) in dogs affected by benign prostatic hyperplasia and evaluation of prostatic blood flow by Doppler ultrasound. Reprod Domest Anim. 2013 Aug;48(4):673-80. PMID: 23320475.

 

Wolf T, Meyer H, Kutzler M. Litter size response to oestrous induction with deslorelin (Ovuplant®) in dogs. Reprod Domest Anim. 2012 Dec;47 Suppl 6:387-8. PMID: 23279545.

" T, Repr.

LKT T0249 Tamibarotene 5 mg 85 RARα/β agonist. Am80 94497-51-5 ≥98% 351.44 C22H25NO3 CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C Ambient 4°C "Kitaoka K, Shimizu N, Ono K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65. PMID: 23624141

 

Yoshikawa O, Ebata Y, Tsuchiya H, et al. A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver. Obesity (Silver Spring). 2013 Jan;21(1):E22-5. PMID: 23404745.

 

Miyabe C, Miyabe Y, Miura NN, et al. Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation. Arthritis Rheum. 2013 Feb;65(2):503-12. PMID: 23203767.

 

Fukasawa H, Nakagomi M, Yamagata N, et al. Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12. PMID: 22863914.

 

Nishimori H, Maeda Y, Teshima T, et al. Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. Blood. 2012 Jan 5;119(1):285-95. PMID: 22077062.

 

Shiohira H, Kitaoka A, Shirasawa H, et al. Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line. Int J Mol Med. 2010 Sep;26(3):393-9. PMID: 20664956.

 

Klemann C, Raveney BJ, Klemann AK, et al. Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. Am J Pathol. 2009 Jun;174(6):2234-45. PMID: 19389933.

" None Not dangerous goods.

LKT D0363 Daptomycin 5 mg 68.3 Anionic lipopeptide, alters cell membrane organization. N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo -3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone 103060-53-3 ≥90% 1620.67 C72H101N17O26 CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C Ambient -20°C Soluble in ethanol (50 mM), methano, DMF, DMSO (100 mM).  Slightly soluble in water (25 mg/mL, 5 mM). "Pogliano J, Pogliano N, Silverman JA. Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins. J Bacteriol. 2012 Sep;194(17):4494-504. PMID: 22661688.

 

Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev Med Chem. 2012 Mar;12(3):202-9. PMID: 22356191

 

Beiras-Fernandez A, Vogt F, Sodian R, et al. Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist. 2010;3:95-101. PMID: 21694898.

" None Not dangerous goods.

LKT T1844 Telbivudine 25 mg 99.75 Nucleoside (thymidine) analog; DNA chain terminator. "Epavudine, L-Thymidine, 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil

β-L-2-deoxythymidine

β-L-thymidine (LdT)

1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione" 3424-98-4 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Nan XP, Zhang Y, Yu HT, et al. Inhibition of viral replication downregulates CD4(+)CD25(high) regulatory T cells and programmed death-ligand 1 in chronic hepatitis B. Viral Immunol. 2012 Feb;25(1):21-8. PMID: 22233255.

 

Lv G, Ying L, Ma WJ, et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J. 2010 Aug 31;7:207. PMID: 20807412.

 

Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005 Aug;129(2):528-36. PMID: 16083710.

" Not dangerous goods.

留言框

  • 产品:

  • 留言内容:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 详细地址:

  • 省份:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
网站首页 公司简介 产品中心 招聘中心 技术支持 企业动态 联系我们 管理登陆
上海易汇生物科技有限公司主营:Eaivelly封板膜|Eaivelly八联管|Eaivelly针式过滤器|Eaivelly光学平盖|Eaivelly荧光定量|代理GE
GoogleSitemap ICP备案号:沪ICP备16010708号-3 技术支持:化工仪器网
张经理
  • 电话

    021-62962298

在线客服
扫一扫访问手机站扫一扫访问手机站
访问手机站